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Article
A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy
The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a ...
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Article
Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy
The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg ...
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Article
Pharmacokinetics of Clobazam and N-Desmethylclobazam in Children with Dravet Syndrome Receiving Concomitant Stiripentol and Valproic Acid
The aim of this study was to describe the pharmacokinetics of clobazam and its active metabolite N-desmethylclobazam (N-CLB) in children with Dravet syndrome receiving the stiripentol/valproic acid/clobazam combi...
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Article
Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
A randomized clinical trial examined whether dexamethasone administration prior to ondansetron followed by etoposide and carboplatin infusions, and single-nucleotide polymorphisms (SNPs) of CYP3A4, CYP3A5 and MDR...
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Article
Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action
In patients infected by HIV, the efficacy of highly active antiretroviral (ARV) therapy through the blockade of different steps of the retrovirus life cycle is now well established. As HIV is a retrovirus that...
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Article
Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART
To assess the relationship between genetic polymorphisms and indinavir pharmacokinetic variability and to study the link between concentrations and short-term response or metabolic safety.
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Article
Pharmacogenomics of Fluorouracil, Irinotecan, and Oxaliplatin in Hepatic Metastases of Colorectal Cancer
Hepatic metastases occur in about half of patients with colorectal cancer. Since hepatic metastases are often not accessible for surgery, chemotherapy of metastases is important. The most commonly used chemoth...
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Article
A SEARCH FOR THE APPROPRIATE SEDATIVE DOSE OF RECTAL MIDAZOLAM IN INFANTS DURING CARDIAC CATHETERIZATION: APPLICATION OF A CONTINUAL REASSESSMENT METHOD. 452
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Article
Excretion of Psychoactive Drugs into Breast Milk
The postpartum period is a time of great physical and emotional changes. The incidence of psychiatric illness is higher in this period than at any other time in a women’s life. Therefore, the question of wheth...
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Article
Vigabatrin
Vigabatrin is a structural analogue of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological activity. [R,S]-Vigabatr...
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Article
Caffeine Acetylator Phenotyping during Maturation in Infants
ABSTRACT: Caffeine acetylator phenotype was studied during maturation in 54 8− to 447-d-old children hospitalized for minor disease (group A) and in five 3− to 630-d-old children with Pierre Robin syndrome (gr...
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Article
Maturation of Caffeine N-Demethylation in Infancy: A Study Using the 13CO2 Breath Test
ABSTRACT: Four premature neonates and eight infants 1–19 months old received caffeine for apnea. The usual morning oral dose was substituted by 1,3,7 13C-trimethylxanthine (13C-tri CAF) as the citrate salt. Five ...
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Article
Transfer in vitro of three benzodiazepines across the human placenta
A comparative study of the placental transfer to the foetus of three benzodiazepines was performed using a dual perfusion system of the human placental lobule. A transport fraction was calculated for each benz...
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Article
Pharmacokinetics of the placental transfer and distribution of clorazepate and its metabolite nordiazepam in the feto-placental unit and in the neonate
Clorazepate 20mg was given i. m. to 49 mothers during the first stage of labour. The elimination of the drug was studied in 27 newborns produced by these mothers. The same dose was given to 13 women who underw...
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Article
Pharmacokinetics of clorazepate in pregnant and non-pregnant women
A single dose of clorazepate 20 mg was injected i.m. in 7 pregnant and 7 non-pregnant women. Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of cl...