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Article
Open AccessSystemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice
Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for Cystic Fibrosis (CF). The most common CF-causing mutation is the deletion of the 508th amino-acid of CFTR (F508...
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Article
Conditional Non-parametric Bootstrap for Non-linear Mixed Effect Models
Non-linear mixed effect models are widely used and increasingly integrated into decision-making processes. Propagating uncertainty is an important element of this process, and while standard errors (SE) on pa-...
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Article
Pharmacokinetic and Pharmacodynamic Optimization of Antibiotic Therapy in Cystic Fibrosis Patients: Current Evidences, Gaps in Knowledge and Future Directions
Antibiotic therapy is one of the main treatments for cystic fibrosis (CF). It aims to eradicate bacteria during early infection, calms down the inflammatory process, and leads to symptom resolution of pulmonar...
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Article
Pharmacokinetic study (phase I−II) of a new dobutamine formulation in preterm infants immediately after birth
Dobutamine is particularly suited to treatment of haemodynamic insufficiency caused by increased peripheral vascular resistance and myocardial dysfunction in the preterm infant. Knowledge of the elimination ha...
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Article
A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy
The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a ...
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Article
Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy
The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg ...
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Chapter
Drug Adherence in Resistant Hypertension
Non-adherence to antihypertensive treatment is recognized as a major factor affecting their effectiveness in hypertensive patients contributing to treatment resistance. Indeed, non-adherence is highly prevalen...
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Article
Open AccessPiperacillin–tazobactam as alternative to carbapenems for ICU patients
Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteria...
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Article
Open AccessSelection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compou...
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Article
Bumetanide for neonatal seizures—back from the cotside
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Article
Pharmacokinetic variability of clindamycin and influence of rifampicin on clindamycin concentration in patients with bone and joint infections
Clindamycin, a lincosamide antibiotic with a good penetration into bone, is widely used for treating bone and joint infections by Gram-positive pathogens. To be active against Staphylococcus spp, its concentratio...
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Article
Pharmacokinetics of Clobazam and N-Desmethylclobazam in Children with Dravet Syndrome Receiving Concomitant Stiripentol and Valproic Acid
The aim of this study was to describe the pharmacokinetics of clobazam and its active metabolite N-desmethylclobazam (N-CLB) in children with Dravet syndrome receiving the stiripentol/valproic acid/clobazam combi...
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Book
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Chapter
Descartes and the Use of Indivisibles
In theory, one would not expect to encounter the use of indivisibles in Descartes’ mathematical work. The core component of the various methods of indivisibles is the use of infinitesimal procedures, whilst Ca...
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Chapter
Archimedes and Indivisibles
Antonio Nardi (?–1656) was a friend of Torricelli and, like him, a pupil of Benedetto Castelli in Rome. It was shown that the thought of Torricelli on indivisibles owed much to Nardi.
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Chapter
Explaining the Sudden Rise of Methods of Indivisibles
This book will analyse the principal methods of indivisibles developed over the course of the seventeenth century. These analyses will be preceded by an examination of the general philosophical arguments regar...
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Chapter
Cavalieri’s Indivisibles
VJ. Cavalieri was born in Milan most probably on 1598. His family was not wealthy; he entered into Jesuats of St. Jerome order and he staid in Pisa, where he met Benedetto Castelli, lecturer in Mathematics at ...
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Chapter
Indivisibles in the Work of Galileo
Galileo’s stated position on indivisibles was far from clear. His work contains a number of doctrinal contradictions and half-hearted statements of intent, and he fails to comment on several important points.
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Chapter
Roberval’s Indivisibles
Cavalieri published his Geometria indivisibilibus continuorum nova quadam ratione promota in 1635. Roberval wrote a “Traité des Indivisibles” which was not published until 1693 but which is attested in the first ...
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Article
Open AccessFixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine
Pharmacokinetic (PK) and pharmacodynamic (PD) data are limited for artesunate (AS) and amodiaquine (AQ) in uncomplicated Plasmodium falciparum.