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725 Result(s)
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Article
O-GlcNAcylation of NLRP3 Contributes to Lipopolysaccharide-Induced Pyroptosis of Human Gingival Fibroblasts
Periodontitis is a leading chronic oral disorder and poses a serious burden on public health. O-GlcNAc glycosylation (O-GlcNAcylation) is regulated only by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) and par...
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Article
LiOH-mediated crystallization regulating strategy enhancing electrochemical performance and structural stability of SiO anodes for lithium-ion batteries
Silicon monoxide (SiO) is widely recognized as a promising anode material for next-generation lithium-ion batteries. Owing to its metastable amorphous structure, SiO exhibits a highly complex degree of crystal...
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Article
Open AccessStructural basis of antagonist selectivity in endothelin receptors
Endothelins and their receptors, ETA and ETB, play vital roles in maintaining vascular homeostasis. Therapeutically targeting endothelin receptors, particularly through ETA antagonists, has shown efficacy in trea...
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Site-Specific Quantitative N-Glycoproteomics: The Great Clinical Application Potential of GlycoQuant
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Article
A novel approach for tip tracking control of a horizontal tensegrity continuum robot with slack cables
Tensegrity continuum robots (TCRs) are an emerging class of flexible continuum robots that employ the tensegrity concept to achieve a natural balance of compliance and strength. The dynamics of a TCR with slac...
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Article
Electrochemically activated metal oxide sites at Rh–Ni2P electrocatalyst for efficient alkaline hydrogen evolution reaction
Highly efficient hydrogen evolution reaction (HER) electrocatalysts play a crucial part in generating green hydrogen. Herein, an electrochemical activation approach was applied to design 6.7 Rh–Ni2P-800CV electro...
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Article
Effect of Ce and Nb on the Microstructure and Properties of 65Si2CrV Spring Steel for Automobile Valve
At present, 65Si2CrV valve spring steel produced by Chinese steel plants mainly faces two problems: poor inclusion control and insufficient strength and toughness. In this experiment, Ce + Nb treatment method ...
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Article
Fermi level tuning in Sn1-xPbxTe/Pb heterostructure via changing interface roughness
Superconducting SnTe-type topological crystalline insulators (TCIs) are predicted to host multiple Majorana zero modes (MZMs) which can coexist in a single vortex. Fermi level (FL) close to the Dirac points of...
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Article
The Foundation of Liberty for the Normativity in Bernard Williams’s Realist Theory of Legitimacy
The discussion of political normativity is a core controversial issue in Bernard Williams’s realist theory of legitimacy. This article attempts to demonstrate that the political normativity in his theory of le...
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Article
Open AccessSpecific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase
The function of proteins depends on their correct structure and proper dynamics. Understanding the dynamics of target proteins facilitates drug design and development. However, dynamic information is often hid...
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Article
Multidimensionally Nano-topologized Polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment-Switched Treatment on Infected Diabetic Wounds
Delayed healing of diabetic wounds poses a major challenge to human health due to severe vascular dysfunction, sustained inflammation, and vulnerability to microbial infection. Herein, we constructed multidime...
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Article
Open AccessUltrasound sensing with optical microcavities
Ultrasound sensors play an important role in biomedical imaging, industrial nondestructive inspection, etc. Traditional ultrasound sensors that use piezoelectric transducers face limitations in sensitivity and...
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Article
Engineering miniature IscB nickase for robust base editing with broad targeting range
IscB has a similar domain organization to Cas9, but the small size of IscB is better suited for delivery by adeno-associated virus. To improve the low editing efficiency of OgeuIscB (IscB from human gut metage...
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Article
Open AccessNeoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This...
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Article
Rigid-flexible-soft coupling dynamic modeling and analysis of clustered tensegrity
Clustered tensegrity structures, which retain the advantages of the classical tensegrity structure, are better controllable, and provide more possibilities for a wide range of application scenarios. However, t...
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Open AccessChanges in temporal lobe activation during a sound stimulation task in patients with sensorineural tinnitus: a multi-channel near-infrared spectroscopy study
The subjective sign of a serious pandemic in human work and life is mathematical neural tinnitus. fNIRS (functional near-infrared spectroscopy) is a new non-invasive brain imaging technology for studying the n...
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High performance CoMoP ternary ionics nanocomposite electrocatalyst for glycerol oxidation coupling with alkaline hydrogen production
Coupling the glycerol oxidation and hydrogen evolution reactions can significantly reduce the energy consumption of the electrolytic water hydrogen production system, achieve hydrogen production while preparin...
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Article
Investigation of Metro Train-Induced Environmental Vibration Using a Coupled Sliced Finite Element-Infinite Element Model
A coupled sliced finite element-infinite element model is developed to analyse the train-induced environmental vibration from metro tunnel by treating the tunnel-ground system as a longitudinal periodic struct...
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Article
Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells
Chemoresistance has emerged as a critical barrier in the treatment of lung cancer. The recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 2, can repair topoisomerase 2-mediated DNA damage, th...
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Article
Fast lithium-ion conductor LiTi2(PO4)3 coating modified LiNi0.8Co0.15Al0.05O2 as cathode material for lithium-ion batteries
Layered high nickel LiNi0.8Co0.15Al0.05O2 (NCA), as one of the most promising cathode materials in lithium-ion batteries, has high specific capacity, stable structure, and environmentally friendly characteristics...