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Article
Evaluation of machine learning-dynamical hybrid method incorporating remote sensing data for in-season maize yield prediction under drought
Effective yield forecasting is a key strategy for adaptation when facing food loss to climate variability. Currently, solar-induced chlorophyll fluorescence (SIF) is an emerging remote-sensing index owing to i...
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Article
Open AccessOptimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explo...
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Article
Influences of ENSO and intraseasonal oscillations on distinct tropical cyclone clusters over the western North Pacific
Although the influences of El Niño–Southern Oscillation (ENSO) and boreal summer intraseasonal oscillation (ISO) on basin-wide tropical cyclone (TC) activity over the western North Pacific (WNP) have been wide...
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Article
Analysis of microRNA-199a-3p expression in CD4+ T cells of systemic lupus erythematosus
Accumulating evidence have suggested microRNAs (miRNAs) play important roles in the pathogenesis of systemic lupus erythematosus (SLE). Here we aimed to explore aberrant expression of miRNAs in CD4+ T cells from ...
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Article
Open AccessAdditive-controlled asymmetric iodocyclization enables enantioselective access to both α- and β-nucleosides
β-Nucleosides and their analogs are dominant clinically-used antiviral and antitumor drugs. α-Nucleosides, the anomers of β-nucleosides, exist in nature and have significant potential as drugs or drug carriers...
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Article
Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Yohimbine is a highly selective and potent α2-adrenoceptor antagonist, which is usually treated as an adjunction for impotence, as well for weight loss and natural bodybuilding aids. However, it was recently repo...
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Article
Open AccessEngineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis development
Osteoarthritis (OA), a prevalent degenerative disease characterized by degradation of extracellular matrix (ECM), still lacks effective disease-modifying therapy. Mesenchymal stem cells (MSCs) transplantation ...
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Chapter and Conference Paper
A Combination of Resampling and Ensemble Method for Text Classification on Imbalanced Data
One of the major factor which can affect the accuracy of text classification is the imbalanced dataset. In order to find the suitable method to handle this issue, six different ensemble methods are used to tra...
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Article
Open AccesstRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients
Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus er...
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Article
Open AccessBMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
Bone has a remarkable potential for self-healing and repair, yet several injury types are non-healing even after surgical or non-surgical treatment. Regenerative therapies that induce bone repair or improve th...
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Article
Open AccessHuman adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model
Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted thera...
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Article
Open AccessDNA-based artificial molecular signaling system that mimics basic elements of reception and response
In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways. Thus, one key chal...
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Article
Open AccessRelease of Porcine Sperm from Oviduct Cells is Stimulated by Progesterone and Requires CatSper
Sperm storage in the female reproductive tract after mating and before ovulation is a reproductive strategy used by many species. When insemination and ovulation are poorly synchronized, the formation and main...
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Article
Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a growing class of natural products found in organisms ranging from plants to humans. The roles these endogenous derivatives of fatty acids play in biology...
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Article
Open AccessNovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; howeve...
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Chapter and Conference Paper
LingoSent — A Platform for Linguistic Aware Sentiment Analysis for Social Media Messages
Sentiment analysis is an important natural language processing (NLP) task and applied to a wide range of scenarios. Social media messages such as tweets often differ from formal writing, exhibiting unorthodox ...
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Article
Adhesion hysteresis of a film-terminated fibrillar array
Motivated by the recent biomimic design of microstructured adhesive surfaces, we study adhesion between a film-terminated fibrillar array and a rigid substrate. Using a two-dimensional model and ignoring the d...
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Article
Open AccessG Protein-Coupled Receptor Kinase 6 Acts as a Critical Regulator of Cytokine-Induced Hyperalgesia by Promoting Phosphatidylinositol 3-Kinase and Inhibiting p38 Signaling
The molecular mechanisms determining magnitude and duration of inflammatory pain are still unclear. We assessed the contribution of G protein-coupled receptor kinase (GRK)-6 to inflammatory hyperalgesia in mic...
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Chapter
On Macro-control Mechanism of the Environmental Capacity Production Factor Market
Believing in that the traditional economics underestimated the importance of environment as a production factor, the paper demanded to view environmental capacity as a basic production factor. Based on such a ...