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Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood. In this study, we discovered that i...
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Open AccessLINC00330/CCL2 axis-mediated ESCC TAM reprogramming affects tumor progression
Tumor-associated macrophages (TAMs) significantly influence the progression, metastasis, and recurrence of esophageal squamous cell carcinoma (ESCC). The aberrant expression of long noncoding RNAs (lncRNAs) in...
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Article
Open AccessN6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA
Hepatic glycogen is the main source of blood glucose and controls the intervals between meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared to their adult counterparts; howeve...
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Article
Open AccessRNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown. ...