-
Article
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood. In this study, we discovered that i...
-
Article
Concurrent multiscale topology optimization of hollow structures considering geometrical nonlinearity
Lattice materials and hollow structures possess excellent mechanical properties, which are beneficial to satisfy the lightweight demands of the products, especially for the large deformation situation. Therefo...
-
Article
An embedded model of cord-reinforced rubber composites for aircraft tires
Aircraft tire is a typical cord-reinforced rubber composite, which consists of unidirectional linear elastic cords and isotropic hyperelastic rubber. The finite element analysis of cord-reinforced rubber compo...
-
Article
Open AccessMacrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
Early and prompt reperfusion therapy has markedly improved the survival rates among patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling and the subsequent onset of heart...
-
Article
Agricultural Vulnerability to Drought in China’s Agro-pastoral Ecotone: A Case Study of Yulin City, Shaanxi Province
Agro-pastoral ecotone of northern China is the prominent area for agricultural production, but it is also the most typical ecological fragile area with frequent drought disasters. Taking Yulin City at Shaanxi ...
-
Article
Bursting oscillations and bifurcation mechanisms in a 4D non-smooth Sprott C model
Non-smooth factors and multiscale couplings are commonly present in daily life and engineering applications. In this research paper, our focus lies in exploring the mechanism behind bursting oscillations and t...
-
Article
MATLAB implementations for 3D geometrically nonlinear topology optimization: 230-line code for SIMP method and 280-line code for MMB method
Topology optimization can generate the innovative material layout to meet the performance demands. Meanwhile, the computational programs with educational purposes were also released for topology optimization. ...
-
Chapter and Conference Paper
Three-Dimensional Vortex Structure Identification of Fluid Coupling and Analysis of Spatial-Temporal Evolution Mechanism
The interior of fluid coupling is full of turbulent and multi-scale vortex flow. The generation, development and interaction of the multi-scale vortex structure dominate the overall internal flow. Accurate ide...
-
Article
Hollow structural topology optimization considering geometrical nonlinearity using three-dimensional moving morphable bars
Hollow structures show higher performance and more easily satisfy lightweight requirements than solid structures in engineering. However, hollow optimized results obtained by topology optimization are currentl...
-
Article
DHEM: a deep heat energy method for steady-state heat conduction problems
Based on the deep energy method recently brought forward to handle linear-elastic or hyper-elastic finite deformation problems in solid mechanics, in this paper, we propose a deep heat energy method (DHEM) whi...
-
Article
Open AccessCorrection: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis
-
Article
Open AccessPKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis
RIG-I-like receptors (RLRs), protein kinase R (PKR), and endosomal Toll-like receptor 3 (TLR3) sense viral non-self RNA and are involved in cell fate determination. However, the mechanisms by which intracellul...
-
Article
Open AccessMETTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is...
-
Article
Complete genome sequence of peony leafroll-associated virus, a novel ampelovirus in subgroup I
The complete genome sequence of peony leafroll-associated virus (PLRaV) was determined by deep sequencing of ribosomal-RNA-depleted total RNA extracted from a peony plant exhibiting leafroll symptoms. Further ...
-
Article
Identification of a novel alphaendornavirus from Lonicera maackii
A new alphaendornavirus, tentatively named “Lonicera maackii alphaendornavirus” (LmEV), was identified in a Lonicera maackii plant in Beijing, China, with leaf abnormality of interveinal chlorosis, and its comple...
-
Article
Stability and Double-Hopf Bifurcations of a Gause–Kolmogorov-Type Predator–Prey System with Indirect Prey-Taxis
In this paper, we deal with the Gause–Kolmogorov-type predator–prey system with indirect prey-taxis, which means that directional movement of predators is stimulated by some chemicals emitted by preys. The exi...
-
Article
Lightweight Design of CFRP-Laminated Structures by Combining Microscopical Homogenization and Macroscopical Optimization
We developed a new method for the design of carbon-fiber reinforced plastic (CFRP)-laminated structures, which combined the asymptotic homogenization method and ply optimization. The equivalent mechanical prop...
-
Article
Nonlinear dynamic topology optimization with explicit and smooth geometric outline via moving morphable components method
For nonlinear dynamic topology optimization, explicit geometry information cannot be obtained with the currently density-based topology optimization methods. To directly obtain an explicit geometry structure i...
-
Article
Stationary distribution and extinction of a stochastic model of syphilis transmission in an MSM population with telegraph noises
This paper is concerned with the dynamical behaviors of a model of syphilis transmission disturbed by both white noises and telegraph noises. Multiple infections and treatment stages are considered, which incl...
-
Article
Topology optimization of thin-walled cross section using moving morphable components approach
Thin-walled beams are extensively applied in the engineering structures, in which the conceptual design of cross-sectional shape and topology is the most important issue. Traditional topology optimization meth...