1,948 Result(s)
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Article
Intestinal Symptoms Among Children aged 2–7 Years with Autism Spectrum Disorder in 13 Cities of China
Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this s...
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Open AccessNode-sparing modified short-course Radiotherapy Combined with CAPOX and Tislelizumab for locally Advanced MSS of Middle and low rectal Cancer (mRCAT): an open-label, single-arm, prospective, multicentre clinical trial
Neoadjuvant chemoradiotherapy followed by total mesorectal excision is a standard treatment for locally advanced rectal cancer. Mismatch repair-deficient locally advanced rectal cancer (LARC) was highly sensit...
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Open AccessSystematic screening of protein-coding gene expression identified VWF as a potential key regulator in anthracycline-based chemotherapy-exacerbated metastasis of breast cancer
Breast cancer is the most commonly diagnosed cancer worldwide. Although major treatments represented by chemotherapy have shown effectiveness at the initial period, recurrence and metastasis still occur later ...
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Open AccessThe senolytic drug ABT-263 accelerates ovarian aging in older female mice
Previous studies have reported that senolytic drugs can reverse obesity-mediated accumulation of senescent cells in the ovary and protect against cisplatin-induced ovarian injury by removing senescent cells. E...
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Open AccessSingle-cell RNA sequencing reveals peripheral immunological features in Parkinson’s Disease
Although many researchers of Parkinson’s disease (PD) have shifted their focus from the central nervous system (CNS) to the peripheral blood, a significant knowledge gap remains between PD severity and the per...
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Open AccessSubacute in-stent thrombosis after carotid artery stenting in a patient with gene polymorphisms associated with aspirin and clopidogrel resistance: a case report
Carotid artery stenting (CAS) is a key treatment option for moderate to severe carotid artery stenosis. Carotid stent thrombosis (CST), a rare complication of CAS, has gained significant attention because of i...
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Open AccessCorrection: The RUBY reporter for visual selection in soybean genome editing
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Molecular mechanism of long non-coding RNA SNHG12 regulating bladder cancer cell activities
Bladder cancer (BC) originating from the bladder mucosa is a malignant tumor of the genitourinary system. Long non-coding RNAs (lncRNAs) can participate in cell proliferation and differentiation at multiple le...
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Methylthio side-chain modified quinoidal benzo-[1,2-b:4,5-b′] dithiophene derivatives for high-performance ambipolar organic field-effect transistors
Quinoidal small molecule semiconductors hold huge potential in ambipolar organic field-effect transistors (OFETs) and organic spintronic devices. Here, two quinoidal molecules with methylthio side chains were ...
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Optimizing microbial electrolysis cell performance: strategies to mitigate electron mediator degradation on membranes
This investigation probes the role of the electron mediator, neutral red (NR), in the electrosynthesis process, specifically examining its effect on the production of succinic acid by Actinobacillus succinogenes....
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Open AccessEstimated glucose disposal rate for predicting cardiovascular events and mortality in patients with non-diabetic chronic kidney disease: a prospective cohort study
Evidence suggests that insulin resistance (IR) is an autonomous risk factor for cardiovascular disease (CVD). Nevertheless, the association between estimated glucose disposal rate (eGDR), a novel indicator of ...
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Open AccessPersonalized neoantigen cancer vaccines: current progression, challenges and a bright future
Tumor neoantigens possess specific immunogenicity and personalized therapeutic vaccines based on neoantigens which have shown promising results in some clinical trials, with broad application prospects. Howeve...
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How Does Students’ Prior Knowledge Affect Learning Behavioral Patterns in CPS-Based STEM Lessons?
In this study, a collaborative problem solving-based STEM course was implemented in a seventh-grade class. This study aimed to examine the effects of students’ prior knowledge on their CPS-based STEM learning ...
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Open AccessRisk factors and prognostic factors associated with retinal detachment and visual outcomes in acute retinal necrosis
To investigate the risk factors and prognostic factors that affect the long-term clinical outcomes of acute retinal necrosis (ARN).
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Open AccessApolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension
Apolipoprotein E (APOE) gene polymorphisms were associated with coronary atherosclerosis and hypertension. However, the relationship between APOE polymorphisms and coronary atherosclerosis susceptibility in hyper...
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Open AccessCRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer
Ovarian cancer, the second most leading cause of gynecologic cancer mortality worldwide, is challenged by chemotherapy resistance, presenting a significant hurdle. Pyroptosis, an inflammation-linked programmed...
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Occurrence, mobility, and potential risk of uranium in an abandoned stone coal mine of Jiangxi Province, China
Metal sulfide oxidation in abandoned exposed stone coal mines leads to the generation of Acid Mine Drainage (AMD), characterized with high uranium concentration, which is a major concern for local public healt...
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Open AccessDownregulating DNA methyltransferase 3B by suppressing the PI3K/Akt signaling pathway enhances the chemosensitivity of glioblastoma to temozolomide
Glioblastoma (GBM) is the most common malignant brain tumor and has the poorest prognosis attributed to its chemoresistance to temozolomide (TMZ), the first-line drug for treating GBM. TMZ resistance represent...
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A tea polyphenol-loaded cellulose/silk fibroin/polyacrylic acid hydrogel for wound healing
Hydrogels can relieve wound pain and provide a moist environment for wound healing. Although hydrogels based on natural materials have proven to be biocompatible and biodegradable, their antibacterial and anti...
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Predicting fatigue life of automotive adhesive bonded joints: a data-driven approach using combined experimental and numerical datasets
The majority of vehicle structural failures originate from joint areas. Cyclic loading is one of the primary factors in joint failures, making the fatigue performance of joints a critical consideration in vehi...