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Article
An universal in-situ phosphating strategy to fabricate high-performance Co2P-based bifunctional oxygen electrocatalyst derived from conjugated polyaniline-phytic acid copolymer
Electrocatalysts play a crucial role in the performance of rechargeable Zn-air batteries (ZABs), but it is still difficult to produce nonprecious materials with excellent bifunctional oxygen reduction reaction...
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Article
Open AccessComparative analyses of plastomes in Allaeanthus and Malaisia: structure, evolution, and phylogeny
The small genera Allaeanthus and Malaisia within the Moraceae have important edible, medicinal, and economic value. However, complete plastome blueprints and a well-resolved evolutionary history of these two gene...
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Article
A universal polymer-assisted route to fabricate Zr-doped TiO2 nanocomposite: boosting reactive desulfurization
A series of transition metal ion-doped TiO2 composites were prepared by polyethyleneimine-assisted solvent-free self-assembly. Due to the similar electronegativity and ionic radius of Ti and Zr ions, the introduc...
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Article
Open AccessConcurrent fabry disease and immunoglobulin a nephropathy: a case report
Fabry disease (FD) is an X-linked, hereditary dysfunction of glycosphingolipid storage caused by mutations in the GLA gene encoding alpha-galactosidase A enzyme. In rare cases, FD may coexist with immunoglobulin ...
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Article
Open AccessExogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma
Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in sev...
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Article
LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a
Gastric cancer (GC) is one of the leading causes of human mortality around the world. We have previously shown that Gαi1 (the inhibitory subunit 1 of the heterotrimeric guanine nucleotide-binding protein) recr...
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Article
Open AccessGlycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which su...
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Article
Open AccessGDC-0349 inhibits non-small cell lung cancer cell growth
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related human mortality with a clear need for new therapeutic intervention. GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor. In...
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Article
Open AccessThe therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells
A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progressio...
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Article
Open AccessThe therapeutic value of SC66 in human renal cell carcinoma cells
The PI3K-AKT-mTOR cascade is required for renal cell carcinoma (RCC) progression. SC66 is novel AKT inhibitor. We found that SC66 inhibited viability, proliferation, migration and invasion of RCC cell lines (7...
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Article
Open AccessA comparison of the use of adipose-derived and bone marrow-derived stem cells for peripheral nerve regeneration in vitro and in vivo
To date, it has repeatedly been demonstrated that infusing bone marrow-derived stem cells (BMSCs) into acellular nerve scaffolds can promote and support axon regeneration through a peripheral nerve defect. How...
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Article
Long-term follow-up of persistent pulmonary pure ground-glass nodules with deep learning–assisted nodule segmentation
To investigate the natural history of persistent pulmonary pure ground-glass nodules (pGGNs) with deep learning–assisted nodule segmentation.
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Article
Open AccessEstradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the ri...
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Article
Open AccessPrognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
CD146, also known as melanoma cell adhesion molecule, was initially identified as a marker of melanoma progression and metastasis. Recently many clinical studies investigated overexpression of CD146 predict po...
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Article
Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder
In humans, the complete lack of tyrosine kinase ZAP70 function results in combined immunodeficiency (CID), with abnormal thymic development and defective T cell receptor (TCR) signaling of peripheral T cells, ...
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Article
Open AccessImpact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis
Over-expression of TROP2 (the trophoblast cell surface antigen 2) was reported to predict poor prognosis in various solid tumors in number of studies. However, the results remained not comprehensive. Therefore...
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Article
Combined effect of obstructive sleep apnea and chronic smoking on cognitive impairment
Little is known about combined effect of obstructive sleep apnea (OSA) and chronic smoking on cognitive impairment. We aimed to determine whether smoking synergizes with OSA in deteriorating cognitive function...
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Article
Increased Expression of p-Akt correlates with Chronic Allograft Nephropathy in a Rat Kidney Model
Chronic allograft nephropathy (CAN) is the most common cause of chronic graft dysfunction leading to graft failure, our study investigates the expression and significance of p-Akt in the pathogenesis of CAN in...
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Article
Open AccessMonitoring response to gefitinib in nude mouse tumor xenografts by 18 F-FDG microPET-CT: correlation between 18 F-FDG uptake and pathological response
The purpose of this study is to investigate whether 18 F-fluorodeoxyglucose (FDG) micro-positron emission tomography-computed tomography (microPET-CT) can be used to monitor a metabolic response to gefitinib in n...
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Article
Factors affecting blood pressure profile in pre and postmenopausal women with obstructive sleep apnea hypopnea syndrome
Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for development of hypertension. Epidemiological surveys have found that risk of cardiovascular diseases increased in postmenopau...
