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Article
Open AccessCircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A
Natural killer cells (NK) are the "professional killer" of tumors and play a crucial role in anti-tumor immunotherapy. NK cell desensitization is a key mechanism of tumor immune escape. Dysregulated NKG2D-NKG2...
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Article
Vector-based uncertain ordered density weighted averaging: a family of incentive-oriented aggregation operators
Incentive is a common phenomenon in the process of decision management. It is important and necessary to integrate incentive requirement into the decision-making process. To this problem, the paper proposed a ...
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Article
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Covalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase i...
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Article
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model
Glioblastoma (GBM) is the most common and aggressive primary brain cancer; angiogenesis and immunosuppression exacerbate GBM progression. COUP-TFII demonstrates pro-angiogenesis activity; however, its role in gli...
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Article
BIS5k: a large-scale dataset for medical segmentation task based on HE-staining images of breast cancer
Breast cancer, a high-incidence cancer among female, occupies a large incidence of total female patients with cancer. Pathological examination is the gold standard for breast cancer in clinic diagnosis. Howeve...
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Article
Open AccessSonically-enhanced in-vehicle air gesture interactions: evaluation of different spearcon compression rates
Driver distraction is a major contributor to road vehicle crashes, and visual distraction caused by using in-vehicle infotainment systems (IVIS) degrades driving performance and increases crash risk. Air gestu...
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Article
Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway
Hypoxia is a key trigger in the transformation of oral leukoplakia into oral cancer. However, it is still too early to determine the role of hypoxia in the development of oral leukoplakia. Prx1, an antioxidant...
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Article
Asymptotic Behavior of Non-autonomous Random Ginzburg–Landau Equations with Colored Noise on Unbounded Thin Domains
This paper is mainly concerned with non-autonomous random complex Ginzburg–Landau equations with nonlinear multiplicative colored noise on unbounded thin domains. Together with the properties of the colored no...
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Article
Open AccessCepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that it has anti-conronaviruses activities including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we as...
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Chapter and Conference Paper
A Qualitative Study for Parametric Designed Custom-Fit Eyewear Frames: Fit Test Evaluation and User Insights
Poor-fitting eyewear frames can lead to discomfort, inconvenience, or hazard for vision. Most eyeglasses are mass-produced in pre-defined sizes, resulting in improper fitting for a portion of the population. W...
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Article
Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging
Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions. Supplementation of exogenous non-ovarian mesenchymal-related cells has bee...
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Article
Influence of the Blocking Effect of Circulating Water Channels on Hydrodynamic Coefficient Estimation for Autonomous Underwater Vehicles
The Reynolds-averaged Navier–Stokes (RANS) equation was solved using computational fluid dynamics to study the effect of the circulating tank wall on the hydrodynamic coefficient of an autonomous underwater ve...
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Article
Microstructure Evolution of Polycrystalline Zinc during Tensile Testing at Room Temperature
In this paper, a pure zinc sample was prepared by extrusion at room temperature and its microstructure evolution during tensile testing was studied by electron back-scattering diffraction (EBSD). The average g...
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Article
Laboratory investigation into curing temperature on the mechanical characteristics of cement mortar serving in rock bolting system
The effect of the curing temperature of cement mortar on the mechanical and deformation characteristics of the full encapsulated rock bolting system was not considered in most previous studies. To reveal the t...
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Article
Open AccessMechanism of lnRNA-ICL involved in lung cancer development in COPD patients through modulating microRNA-19-3p/NKRF/NF-κB axis
The incidence of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients is dozens of times higher than that in patients without COPD. Elevated activity of nuclear factor-k-gene binding (NF-κ...
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Article
pH-Responsive polyethyleneimine hydrogel based on dynamic covalent bonds
Smart hydrogels with excellent stimulus-responsiveness can be applied to a variety of fields. Herein, a new smart hydrogel with pH-responsive, reversible gel-fluid transition properties and self-healing abilit...
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Article
Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms
Sirt6, a class III NAD+-dependent deacetylase of the sirtuin family, is a highly specific H3 deacetylase and plays important roles in regulating cellular growth and death. The induction of oxidative stress and de...
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Article
Open AccessCorrection to: PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
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Article
Open AccessPKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder, mainly characterized by the development of renal cysts, as well as various extrarenal manifestations. Previous studies have...
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Article
Influences of dynamic normal disturbance and initial shear stress on fault activation characteristics
Dynamic disturbance resulting from blasting, excavation, and earthquakes might change the stress state, friction characteristics, failure mechanism, and the fault’s failure mode, induce the activation of stead...