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Article
Open AccessCircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A
Natural killer cells (NK) are the "professional killer" of tumors and play a crucial role in anti-tumor immunotherapy. NK cell desensitization is a key mechanism of tumor immune escape. Dysregulated NKG2D-NKG2...
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Article
Clinical features and surgical treatments of scoliosis in neurofibromatosis type 1: a systemic review and meta-analysis
Neurofibromatosis type 1 (NF 1) is an autosomal-dominant tumor predisposition genetic disease affecting approximately 1 in 3000 live births. The condition could present various manifestations ranging from skin...
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Article
Open AccessAlantolactone enhances the sensitivity of melanoma to MAPK pathway inhibitors by targeting inhibition of STAT3 activation and down-regulating stem cell markers
Mitogen-activated protein kinase inhibitors (MAPKi) were the first line drugs for advanced melanoma patients with BRAF mutation. Targeted therapies have significant therapeutic effects; however, drug resistanc...
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Article
Longitudinal and Reciprocal Effects in the Association Between School Bullying and Homicidal Ideation During Early Adolescence
Several cross-sectional studies indicated a positive association between school bullying and homicidal ideation during early adolescence. However, few longitudinal studies investigated this association. This s...
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Article
Cognitive flexibility and social adjustment in daily life among children: The role of perceived social support
This study investigates the link between cognitive flexibility and children’s social adjustment, focusing on the mediating role of perceived social support. A sample of 185 elementary school children, aged 9–1...
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Article
Open AccessProfiling the role of m6A effectors in the regulation of pluripotent reprogramming
The N6-methyladenosine (m6A) RNA modification plays essential roles in multiple biological processes, including stem cell fate determination. To explore the role of the m6A modification in pluripotent reprogrammi...
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Article
Open AccessKeto-anthraquinone covalent organic framework for H2O2 photosynthesis with oxygen and alkaline water
Hydrogen peroxide photosynthesis suffers from insufficient catalytic activity due to the high energy barrier of hydrogen extraction from H2O. Herein, we report that mechanochemically synthesized keto-form anthraq...
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Article
Brain structural and functional signatures of multi-generational family history of suicidal behaviors in preadolescent children
Parent-child transmission of suicidal behaviors has been extensively studied, but the investigation of a three-generation family suicide risk paradigm remains limited. In this study, we aimed to explore the be...
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Chapter and Conference Paper
Typical Faults Recognizing for Seal Rings of Hydro-Dynamic Shaft Seal of Reactor Coolant Pump Based on ANN and Experimental Research
The hydro-dynamic shaft seal of the main coolant pump operates under strict conditions and serves as a critical barrier of the pressure water reactor. In this paper, in order to study the possible defects and ...
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Article
Open AccessProfiling mitochondria-polyribosome lncRNAs associated with pluripotency
Pluripotent stem cells (PSCs) provide unlimited resources for regenerative medicine because of their potential for self-renewal and differentiation into many different cell types. The pluripotency of these PSC...
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Article
The transition trajectories of self-injurious thoughts and behaviours among children from a biopsychosocial perspective
Although self-injurious thoughts and behaviours (SITB) among children pose an imminent public health concern, the comprehensive understanding of SITB transitions remains unclear. Here we used the longitudinal ...
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Article
Open AccessApplication of multi-modality MRI-based radiomics in the pre-treatment prediction of RPS6K expression in hepatocellular carcinoma
In this study, we aim to develop and validate a radiomics model for pretreatment prediction of RPS6K expression in hepatocellular carcinoma (HCC) patients, thus helping clinical decision-making of mTOR-inhibit...
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Article
Open AccessPrognostic value of IKBIP in papillary renal cell carcinoma
I kappa B kinase interacting protein, a highly conserved gene, has rarely been reported in cancer. According to previous study, IKBIP has only been shown to promote malignant progression of glioma. In other ma...
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Article
Mindfulness and emotional experience in daily life among elementary school students: The role of mind-wandering
As children go to elementary school, their main activities shift from games to learning, making them experience stronger emotional experiences than ever. Previous studies indicated that mindfulness could affec...
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Article
MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration
The endometrial basal layer is essential for endometrial regeneration, whose disruption leads to thin endometrium or intrauterine adhesion (IUA) with an unsatisfactory prognosis. Emerging data indicate that pl...
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Article
Novel targets for immunotherapy associated with exhausted CD8 + T cells in cancer
In response to prolonged stimulation by tumour antigens, T cells gradually become exhausted. There is growing evidence that exhausted T cells not only lose their potent effector functions but also express mult...
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Article
Open AccessAssociations of bullying perpetration and peer victimization subtypes with preadolescent’s suicidality, non-suicidal self-injury, neurocognition, and brain development
Although both peer victimization and bullying perpetration negatively impact preadolescents’ development, the underlying neurobiological mechanism of this adverse relationship remains unclear. Besides, the spe...
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Article
Identification of three potential novel biomarkers for early diagnosis of acute ischemic stroke via plasma lipidomics
Acute ischemic stroke (AIS) accounts for the majority of all stroke, globally the second leading cause of death. Due to its rapid development after onset, its early diagnosis is crucial.
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Article
Open AccessGrpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study
Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a nucleotide exchange factor, has been shown to regulate mitochondrial import p...
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Article
Ambulatory and longitudinal relationships between mindfulness and eating problems: The mediating role of self-objectification
Previous research has shown a negative association between mindfulness and its facets and eating problems. Few studies have examined the mechanism involved between them. As an important cognitive factor of eat...