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Article
Open AccessHsa_circ_0013561 promotes epithelial-mesenchymal transition and tumor progression by regulating ANXA2 via miR-23b-3p in ovarian cancer
Our preliminary experiment discovered that hsa_circ_0013561 was aberrantly expressed in OC. However, the underlying mechanism is unclear. The expression of hsa_circ_0013561 in OC cells and tissues was detected...
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Article
Open AccessLow-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics study
Tumor cells with stemness in breast cancer might facilitate the immune microenvironment’s suppression process and led to anti-tumor immune effects. The primary objective of this study was to identify potential...
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Article
Open AccessDynamic characteristics and functional analysis provide new insights into the role of GauERF105 for resistance against Verticillium dahliae in cotton
The cotton industry suffers significant yield losses annually due to Verticillium wilt, which is considered the most destructive disease affecting the crop. However, the precise mechanisms behind this disease ...
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Article
Insights to Gossypium defense response against Verticillium dahliae: the Cotton Cancer
The soil-borne pathogen Verticillium dahliae, also referred as “The Cotton Cancer,” is responsible for causing Verticillium wilt in cotton crops, a destructive disease with a global impact. To infect cotton plant...
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Article
Quantitative Characterization of the Elasticity, Net Creep, and Swelling of the Intervertebral Disc: An In Vitro Experiment
During the in vitro creep of intervertebral discs, both applied loads and osmosis of solution influence their biomechanical behaviors. More specifically, the total displacement can be attributed to three parts...
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Article
Open AccessNuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical a...
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Article
Open AccessIsolation and identification of a feather degrading Bacillus tropicus strain Gxun-17 from marine environment and its enzyme characteristics
Feathers are the most abundant agricultural waste produced by poultry farms. The accumulation of a large number of feathers not only seriously pollutes the environment but also causes the waste of protein reso...
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Article
A photoelectrochemical aptasensor of ciprofloxacin based on Bi24O31Cl10/BiOCl heterojunction
A photoelectrochemical (PEC) aptasensor was designed and constructed by Bi24O31Cl10/BiOCl heterojunction as a photoelectric active material for realizing the determination of trace ciprofloxacin (CIP) in water. C...
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Article
Expressions and clinical significances of STAT3 and Grim19 in epithelial ovarian cancer
This study aimed to explore the expressions of signal transducer and activator of transcription 3 (STAT3) and a gene associated with retinoid-interferon induced mortality (Grim19) in epithelial ovarian cancer ...
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A Girl Behind a Closed Door
Yi Shi, female, born in 1992. Grade III intellectual disability. Has a younger brother. Graduated from a special school—Zhonghua Vocational School, and joined the Sunshine Home in Shanghai in 2013.
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Article
Open AccessActivation of Aurora A kinase increases YAP stability via blockage of autophagy
Transcription cofactor Yes-associated protein (YAP) plays an important role in cancer progression. Here, we found that Aurora A kinase expression was positively correlated with YAP in lung cancer. Aurora A dep...
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Article
Open AccessTranscriptomic but not genomic variability confers phenotype of breast cancer stem cells
Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy. Although several discoveri...
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Article
Open AccessNew insights from the widening homogeneity perspective to target intratumor heterogeneity
Precision medicine has shed new light on the treatment of heterogeneous cancer patients. However, intratumor heterogeneity strongly constrains the clinical benefit of precision medicine. Thus, rethinking thera...