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Open AccessThe recruitment of CD8+ T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma
Previous studies revealed that MIR155HG possessed an oncogenic role in many types of tumors including lung adenocarcinoma (LUAD), along with higher expression in tumors. However, in our study, we observed a po...
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Article
A New Process of Chlorine Deep Removal in Zinc Sulfate by Highly Active Copper from Copper Slag
Chloride concentration is one of the important factors that seriously affect the electrolysis of zinc sulfate. The copper slag used in the copper slag dechlorination method has low activity due to long-term st...
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Article
Open AccessFerritinophagy mediates adaptive resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer
Osimertinib (Osi) is a widely used epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). However, the emergence of resistance is inevitable, partly due to the gradual evolution of adaptive res...
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Article
Open AccessA SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), which functions as a robust co-activator of POU2F3, the master transcription factor which is critical fo...
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Article
Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine
Arterial stiffness is a major contributor to morbidity and mortality worldwide. Although several metabolic markers associated with arterial stiffness have been developed, there is limited data regarding whethe...
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Article
Open AccessTriglyceride-glucose index, renal function and cardiovascular disease: a national cohort study
The triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG index is associated with cardiovascular diseases through renal function is unclear. This study ai...
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Article
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer
The clinical efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) is limited by the emergence of drug resistance. We hypothesise that restoring dysregulated circular RNAs under i...
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Article
Novel Mechanisms of Perioperative Neurocognitive Disorders: Ferroptosis and Pyroptosis
Perioperative neurocognitive disorders (PNDs) are some of the most common postoperative complications among the elderly and susceptible individuals, which significantly worsens the clinical outcome of patients...
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Article
Research on Depth Dechlorination by Copper Slag Valence Regulation of Synergistic High-Activity Copper in the Ultrasonic Field
Due to the problems of cuprous chloride resolution and low copper activity in traditional copper slag dechlorination process, depth dechlorination by copper slag valence regulation of synergistic high-activity...
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Article
Open AccessCharacterization and commissioning of a new collaborative multi-modality radiotherapy platform
TaiChi, a new multi-modality radiotherapy platform that integrates a linear accelerator, a focusing gamma system, and a kV imaging system within an enclosed O-ring gantry, was introduced into clinical applicat...
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Article
Open AccessLncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells
The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate ranks first.
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Article
Open AccessThe super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma
Super-enhancers (SEs) are regulatory element clusters related to cell identity and disease. While the studies illustrating the function of SE-associated long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LU...
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Evaluation of Copper Levels in Dental Calculus of OSF Patients with Chewing Dried Areca-Nut Quids in Hunan Province of Mainland China
Dental calculus is a potential material that can be used for assessing chronic exposure to trace heavy metals in oral cavity as it is a long-term reservoir. The aim of this study was to investigate the correla...
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Article
Open AccessNon-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype
Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the understanding of non-genetic variation provides a new perspective to study the heterogenei...
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Article
Open AccessSuper-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway
Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, the roles of long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements of the epigenome, remain elu...
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Article
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells
Dysregulation of the Hippo signaling pathway seen in many types of cancer is usually associated with a poor prognosis. Paris saponin VII (PSVII) is a steroid saponin isolated from traditional Chinese herbs wit...
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Open AccessA novel gene expression signature-based on B-cell proportion to predict prognosis of patients with lung adenocarcinoma
This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD.
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Article
Mn2O3 porous microsheets prepared by a chemical precipitation method as an effective electrochemical sensor for non-enzymatic glucose detection
To conveniently construct an electrochemical non-enzymatic glucose sensor, Mn2O3 porous microsheets are utilized as electrode materials in glucose detection. Mn2O3 porous microsheets have been prepared by a facil...
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Article
Efficient photocatalysis and sustainable degradation of methylene blue by titanium dioxide and zinc oxide supported on spent FCC catalyst
Zinc oxide (ZnO) and titanium dioxide (TiO2) are loaded on the spent fluid catalytic cracking catalyst (FCC) via an impregnation method to form the composite material, which is named as Zn–Ti/FCC in this article....
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Open AccessCircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
Mutation or downregulation of p53 (encoded by TP53) accelerates tumorigenesis and malignant progression in esophageal squamous cell carcinoma (ESCC). However, it is still unknown whether circular RNAs (circRNA...