31 Result(s)
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Open AccessDiscovery of the first Tn630 member and the closest homolog of IS630 from viruses
IS630/Tc1/mariner (ITm) represents the most widely distributed superfamily of DNA transposons in nature. Currently, bioinformatics research on ITm members primarily involves collecting data of existing and emergi...
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Open AccessAuthor Correction: Natural ventilation cooling effectiveness classification for building design addressing climate characteristics
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Open AccessDSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis
DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by c...
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Open AccessNatural ventilation cooling effectiveness classification for building design addressing climate characteristics
The evaluation of natural ventilation potential for effective sustainable options and innovative green building design strategies is of great interest to architects, researchers and governments. From a retrosp...
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Open AccessCarotenoid biosynthesis genes LcLCYB, LcLCYE, and LcBCH from wolfberry confer increased carotenoid content and improved salt tolerance in tobacco
Carotenoids play essential roles in plant growth and development and provide plants with a tolerance to a series of abiotic stresses. In this study, the function and biological significance of lycopene β-cycla...
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Open AccessIncidence, risk and prognosis of second primary malignancy of patients with gastric adenocarcinoma
Due to the long-term low survival rates of gastric adenocarcinoma (GAC) patients, the occurrence and prognosis of second primary malignancies (SPMs) are often underreported and overlooked as a significant conc...
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Open AccessDevelopment and validation of predictive nomogram for postoperative non-union of closed femoral shaft fracture
Closed femoral shaft fracture is caused by high-energy injuries, and non-union exists after operation, which can significantly damage patients’ body and mind. This study aimed to explore the factors influencin...
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Open AccessConstruction of an abnormal glycosylation risk model and its application in predicting the prognosis of patients with head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck, and the incidence rate is increasing year by year. Protein post-translational modification, recognized as ...
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Open AccessShikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
Doxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits its clinical application. Shikonin has a wide range of biological functions, including antioxidant and anti-inflammatory...
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Open AccessGenomics and transcriptomics of the Chinese mitten crabs (Eriocheir sinensis)
To gain a deeper understanding of the genetic factors influencing the growth and development of Eriocheir sinensis, a well-known species of hairy crab found in Yangcheng Lake, this study focused on the de novo...
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Open AccessBiofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy
The treatment of diabetic wounds faces enormous challenges due to complex wound environments, such as infected biofilms, excessive inflammation, and impaired angiogenesis. The critical role of the microenviron...
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Open AccessDeep learning personalized recommendation-based construction method of hybrid blockchain model
This study aims to explore the construction of a personalized recommendation system (PRS) based on deep learning under the hybrid blockchain model to further improve the performance of the PRS. Blockchain tech...
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Open AccessExpansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche
Limited numbers of available hematopoietic stem cells (HSCs) limit the widespread use of HSC-based therapies. Expansion systems for functional heterogenous HSCs remain to be optimized. Here, we present a conve...
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Open AccessRapid diagnosis of membranous nephropathy based on serum and urine Raman spectroscopy combined with deep learning methods
Membranous nephropathy is the main cause of nephrotic syndrome, which has an insidious onset and may progress to end-stage renal disease with a high mortality rate, such as renal failure and uremia. At present...
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Open AccessA comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics
The emergence of Omicron variant raises great concerns because of its rapid transmissibility and its numerous mutations in spike protein (S-protein). S-protein can act as a pathogen-associated molecular patter...
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Open AccessGeospatial characterization of rural settlements and potential targets for revitalization by geoinformation technology
To better implement the Strategy of Rural Revitalization, it is essential to characterize the rural settlements and understand their roles in the socio-environmental interactive system. This paper is hence aim...
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Open AccessDevelopment of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservatio...
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Open AccessA synergetic effect of BARD1 mutations on tumorigenesis
To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most of them are classified into benign or unidentified alterations due to their undetectable phenotype...
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Open AccessMolecular mechanism for vitamin C-derived C5-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1
C5-glyceryl-methylcytosine (5gmC) is a novel DNA modification catalyzed by algal TET homologue CMD1 using vitamin C (VC) as co-substrate. Here, we report the structures of CMD1 in apo form and in complexes with ....
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Open AccessRoom-temperature liquid diffused separation induced crystallization for high-quality perovskite single crystals
Large single crystals serve as an ideal platform for investigating intrinsic material properties and optoelectronic applications. Here we develop a method, namely, room-temperature liquid diffused separation i...
