115 Result(s)
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Article
Open AccessExpanding the targeting scope of CRISPR/Cas9-mediated genome editing by Cas9 variants in Brassica
CRISPR/Cas9, presently the most widely used genome editing technology, has provided great potential for functional studies and plant breeding. However, the strict requirement for a protospacer adjacent motif (...
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Article
Open AccessEffect of oral administration of microcin Y on growth performance, intestinal barrier function and gut microbiota of chicks challenged with Salmonella Pullorum
The lasso peptide microcin Y (MccY) effectively inhibits various serotypes of Salmonella in vitro, but the antibacterial effect against S. Pullorum in poultry is still unclear. This study was the first to evaluat...
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Article
Open AccessHydrogen gas inhalation ameliorates LPS-induced BPD by inhibiting inflammation via regulating the TLR4–NFκB–IL6/NLRP3 signaling pathway in the placenta
Hydrogen (H2) is regarded as a novel therapeutic agent against several diseases owing to its inherent biosafety. Bronchopulmonary dysplasia (BPD) has been widely considered among adverse pregnancy outcomes, witho...
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Article
Open AccessCorrection: A risk prediction model for postoperative recovery of closed calcaneal fracture: a retrospective study
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Article
Open AccessCarotenoid biosynthesis genes LcLCYB, LcLCYE, and LcBCH from wolfberry confer increased carotenoid content and improved salt tolerance in tobacco
Carotenoids play essential roles in plant growth and development and provide plants with a tolerance to a series of abiotic stresses. In this study, the function and biological significance of lycopene β-cycla...
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Article
Open AccessLongitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia
This study reported height prediction and longitudinal growth changes in Chinese pediatric patients with acute myeloid leukemia (AML) during and after treatment and their associations with outcomes.
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Article
Open AccessTumor microenvironment reprogramming combined with immunogenic enhancement by nanoemulsions potentiates immunotherapy
The combination of immune checkpoint inhibitors and immunogenic cell death (ICD) inducers has become a promising strategy for the treatment of various cancers. However, its efficacy remains unmet because of th...
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Article
Open AccessArthroscopic surgery for ankle gouty arthritis: a retrospective analysis of clinical outcomes at six month follow-up based on a novel classification system
This study aimed to evaluate the clinical outcomes, patient-reported outcomes, and recurrence rate of patients diagnosed with ankle gouty arthritis who underwent arthroscopic surgery based on the new classific...
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Article
Open AccessBiochar-supported zero-valent iron enhanced arsenic immobilization in a paddy soil: the role of soil organic matter
Arsenic (As) detoxification in polluted soils by iron-based materials can be mediated by the endogenous soil organic matter (SOM), nevertheless the mechanisms remain unclear. Herein, endogenous SOM in a paddy ...
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Article
Open AccessIncidence, risk and prognosis of second primary malignancy of patients with gastric adenocarcinoma
Due to the long-term low survival rates of gastric adenocarcinoma (GAC) patients, the occurrence and prognosis of second primary malignancies (SPMs) are often underreported and overlooked as a significant conc...
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Article
Open AccessDevelopment and validation of predictive nomogram for postoperative non-union of closed femoral shaft fracture
Closed femoral shaft fracture is caused by high-energy injuries, and non-union exists after operation, which can significantly damage patients’ body and mind. This study aimed to explore the factors influencin...
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Article
Open AccessGinseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways
Inflammatory bowel disease (IBD) is closely linked to the homeostasis of the intestinal environment, and exosomes can be used to treat IBD due to their high biocompatibility and ability to be effectively absor...
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Article
Open AccessConstruction of an abnormal glycosylation risk model and its application in predicting the prognosis of patients with head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck, and the incidence rate is increasing year by year. Protein post-translational modification, recognized as ...
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Article
Open AccessShikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
Doxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits its clinical application. Shikonin has a wide range of biological functions, including antioxidant and anti-inflammatory...
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Chapter and Conference Paper
Estimating the Impacts of Seasonal Variations of Streetscape on Dockless Bike Sharing Trip with Street View Images and Computer Vision
A significant portion of the cycling experience is influenced by the streetscape, and this impact varies throughout the year. The temporal dynamic of streetscape has been neglected in most previous studies, in...
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Chapter and Conference Paper
The Use of Normative Energy Calculation for Natural Ventilation Performance-Driven Urban Block Morphology Generation
Exploring the three-state coupling relationship between “urban block morphology, carbon emissions, and human comfort” is necessary when making preliminary design decisions. Currently, morphology generative des...
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Article
Open AccessHypergraph convolution mix DDPG for multi-aerial base station deployment
Aerial base stations (AeBS), as crucial components of air-ground integrated networks, can serve as the edge nodes to provide flexible services to ground users. Optimizing the deployment of multiple AeBSs to ma...
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Article
Open AccessPPO-based deployment and phase control for movable intelligent reflecting surface
Intelligent reflecting surface (IRS) stands as a promising technology to revolutionize wireless communication by manipulating incident signal amplitudes and phases to enhance system performance. While existing...
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Article
Open AccessGenomics and transcriptomics of the Chinese mitten crabs (Eriocheir sinensis)
To gain a deeper understanding of the genetic factors influencing the growth and development of Eriocheir sinensis, a well-known species of hairy crab found in Yangcheng Lake, this study focused on the de novo...
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Article
Open AccessBiofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy
The treatment of diabetic wounds faces enormous challenges due to complex wound environments, such as infected biofilms, excessive inflammation, and impaired angiogenesis. The critical role of the microenviron...