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Open AccessNatural variation of domestication-related genes contributed to latitudinal expansion and adaptation in soybean
Soybean is a major source of protein and edible oil worldwide. Originating from the Huang-Huai-Hai region, which has a temperate climate, soybean has adapted to a wide latitudinal gradient across China. Howeve...
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Article
Open AccessHighly reversible zinc metal anode enabled by strong Brønsted acid and hydrophobic interfacial chemistry
Uncontrollable zinc (Zn) plating and hydrogen evolution greatly undermine Zn anode reversibility. Previous electrolyte designs focus on suppressing H2O reactivity, however, the accumulation of alkaline byproducts...
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Article
Open AccessTumor microenvironment reprogramming combined with immunogenic enhancement by nanoemulsions potentiates immunotherapy
The combination of immune checkpoint inhibitors and immunogenic cell death (ICD) inducers has become a promising strategy for the treatment of various cancers. However, its efficacy remains unmet because of th...
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Identification of quantitative trait loci and candidate genes for seed folate content in soybean
From 61 QTL mapped, a stable QTL cluster of 992 kb was discovered on chromosome 5 for folate content and a putative candidate gene, Glyma.05G237500, was identified.
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Article
Open AccessThe feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling
Innate radioresistance substantially limits the effectiveness of radiotherapy for colorectal cancer (CRC); thus, a strategy to enhance the radiosensitivity of CRC is urgently needed. Herein, we reported that a...
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Article
Open AccessElevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth
The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation and progression of human cancer. Its expression, potential funct...
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Article
Treatment of CML-transformed B Cell Acute Lymphoblastic Leukemia (B-ALL) in Adults with Anti-CD19 Chimeric Antigen Receptor T Cell (CAR T) Therapy
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Open AccessPD-L1 is a critical mediator of regulatory B cells and T cells in invasive breast cancer
Regulatory T cells (Tregs), a key mediator in regulating anti-tumor immune suppression, tumor immune escape, metastasis and relapse, are considered an important therapeutic target in immunotherapy of human can...