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178 Result(s)
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Article
Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia
Acute myelocytic leukemia seriously impairs the health and lifespan of patients; thus, effective treatment methods for acute myelocytic leukemia need to be urgently determined. This study aimed to investigate ...
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Open AccessA horizontal and perpendicular interlaminar approach for intrathecal nusinersen injection in patients with spinal muscular atrophy and scoliosis: an observational study
Lumbar puncture is challenging for patients with scoliosis. Previous ultrasound-assisted techniques for lumbar puncture used the angle of the probe as the needle trajectory; however, reproducing the angle is d...
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Open AccessSummary of the National Cancer Institute 2023 Virtual Workshop on Medical Image De-identification—Part 2: Pathology Whole Slide Image De-identification, De-facing, the Role of AI in Image De-identification, and the NCI MIDI Datasets and Pipeline
De-identification of medical images intended for research is a core requirement for data sharing initiatives, particularly as the demand for data for artificial intelligence (AI) applications grows. The Center...
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Open AccessConstruction of lignan glycosides biosynthetic network in Escherichia coli using mutltienzyme modules
Due to the complexity of the metabolic pathway network of active ingredients, precise targeted synthesis of any active ingredient on a synthetic network is a huge challenge. Based on a complete analysis of the...
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Article
Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study
This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
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Article
Open AccessIRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure
Immune-related GTPase M (IRGM) induces autophagy and suppresses inflammation, but its putative role and signaling mechanism remain undefined in the pathogenesis of liver failure. This study aimed to address ho...
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Open AccessImplantation of Adipose-Derived Mesenchymal Stromal Cells (ADSCs)-Lining Prosthetic Graft Promotes Vascular Regeneration in Monkeys and Pigs
Current replacement procedures for stenosis or occluded arteries using prosthetic grafts have serious limitations in clinical applications, particularly, endothelialization of the luminal surface is a long-sta...
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Article
Cardiovascular comorbidities and their prognostic value in small cell lung cancer patients with chemoradiotherapy
Small cell lung cancer (SCLC) is an extremely malignant subtype of lung cancer because of its high potential for metastases. Cardiac invasion of SCLC is a serious concern that may lead to systemic embolism or ...
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Open AccessscCDC: a computational method for gene-specific contamination detection and correction in single-cell and single-nucleus RNA-seq data
In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene expression levels. Existing methods correct the contamination...
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Open AccessCharacterization of PANoptosis-related genes in Crohn’s disease by integrated bioinformatics, machine learning and experiments
Currently, the biological understanding of Crohn’s disease (CD) remains limited. PANoptosis is a revolutionary form of cell death reported to participate in numerous diseases, including CD. In our study, we ai...
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Open AccessEvaluation of optical coherence tomography angiography metrics in children and adolescents with type 1 diabetes: 4-year longitudinal study
To evaluate longitudinal changes in optical coherence tomography angiography (OCTA) metrics in children and adolescents with type 1 diabetes (T1D).
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Article
Open AccessBeneficial effects of time-restricted fasting on cardiovascular disease risk factors: a meta-analysis
Cardiovascular disease continues to be a leading cause of mortality worldwide, highlighting the need to explore innovative approaches to improve cardiovascular health outcomes. Time-restricted fasting (TRF) is...
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Article
Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis
Patients with end-stage liver disease (ESLD) are susceptible to invasive pulmonary aspergillosis (IPA). This study aimed to investigate the risk factors affecting the occurrence and short-term prognosis of ESL...
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Open AccessTranscriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7
Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differenti...
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Article
Open AccessDigital twins for health: a scoping review
The use of digital twins (DTs) has proliferated across various fields and industries, with a recent surge in the healthcare sector. The concept of digital twin for health (DT4H) holds great promise to revoluti...
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Article
Open AccessTrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua. The augmentation of trichome density has been demonstrated to enhance artemisinin yield. Ho...
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Retrospective analysis of preoperative application of triple-modal pre-rehabilitation on postoperative recovery of colorectal cancer patients
To retrospectively analyze the difference between triple-modal pre-rehabilitation and common treatment in patients with colorectal cancer (CRC).
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Article
Performance of Zeolite and Trace Elements on Biogas Production from Alkaline Hydrogen Peroxide–Pretreated Sweet Sorghum Bagasse Slurry
In order to improve the biogas production from sweet sorghum bagasse (SSB) pretreated with alkaline hydrogen peroxide and reveal the influence of zeolite dosage and TE on the anaerobic digestion performance, a...
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Open AccessThe relationship between theory of mind and moral sensitivity among Chinese preschool children: the mediating role of empathy
Identifying moral behavior in complex situations is the key ability for children to develop prosocial behavior. The theory of mind (ToM) and empathy provide the cognition and emotional motivation required for ...
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Article
Open AccessEfficacy of radiotherapy in combined treatment of hepatocellular carcinoma patients with portal vein tumor thrombus: a real-world study
Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) has an extremely poor prognosis. A previous study proved that low-dose radiotherapy (RT) could prolong the prognosis of HCC patients with P...