The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of... more The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of English philology. It publishes book-length studies and essay collections on English language and linguistics, on English and American literature and culture from the Middle Ages to the present, on the new English literatures, as well as on general and comparative literary studies, including aspects of cultural and literary theory
Lenker, Ursula. 2023. “‘And fare now wel …’: Functions of Imperatives in Middle English Verbal In... more Lenker, Ursula. 2023. “‘And fare now wel …’: Functions of Imperatives in Middle English Verbal Interaction”. In: Renate Bauer, Christine Elsweiler, Ulrike Krischke and Kerstin Majewski (eds.). Texts Travelling – Travelling Texts. A Gedenkschrift in Memory of Hans Sauer. München: utz, 2023, 123-141.
Yearbook of the German Cognitive Linguistics Association, Oct 1, 2020
Background: Sarcoidosis is a granulomatous disorder of unknown etiology. The term of immunoangios... more Background: Sarcoidosis is a granulomatous disorder of unknown etiology. The term of immunoangiostasis has been addressed by various studies as potentially involved in the disease pathogenesis. The aim of the study was to investigate the expression of the master regulator of angiogenesis hypoxia inducible factor (HIF)-1avascular endothelial growth factor (VEGF)-inhibitor of growth factor 4-(ING4)-axis within sarcoid granuloma. Methods: A total of 37 patients with sarcoidosis stages II-III were recruited in our study. Tissue microarray technology coupled with immunohistochemistry analysis were applied to video-assisted thoracoscopic surgery (VATS) lung biopsy samples collected from 37 sarcoidosis patients and 24 controls underwent surgery for benign lesions of the lung. Computerized image analysis was used to quantify immunohistochemistry results. qRT-PCR was used to assess HIF-1a and ING4 expression in 10 sarcoidosis mediastinal lymph node and 10 control lung samples. Results: HIF-1a and VEGF-ING4 expression, both in protein and mRNA level, was found to be downregulated and upregulated, respectively, in sarcoidosis samples compared to controls. Immunohistochemistry coupled with computerized image analysis revealed minimal expression of HIF-1a within sarcoid granulomas whereas an abundant staining of ING4 and VEGF in epithelioid cells was also visualized. Conclusions: Our data suggest an impairment of the HIF-1a-VEGF axis, potentialy arising by ING4 overexpression and ultimately resulting in angiostasis and monocyte recruitment within granulomas. The concept of immunoangiostasis as a possible protection mechanism against antigens of infectious origin needs further research to be verified.
At the end of the 2021 issues, Lucia Kornexl retired from the editorial board of Anglia. We very ... more At the end of the 2021 issues, Lucia Kornexl retired from the editorial board of Anglia. We very much hope that, despite this official farewell, her advice, help, knowledge and astute judgement will remain with us. Andrew James Johnston, whom we introduce to our readers in the following article, joins the editorial team of Anglia from the present volume. We would like to express our great sadness about the sudden deaths of two members of our advisory board: J. Hillis Miller passed away on February 7, 2021. Laura Marcus died on September 22, 2021. Both of them were exceptional scholars in their fields with a worldwide reputation. We are grateful for their service on our advisory board and shall miss them much.
The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of... more The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of English philology. It publishes book-length studies and essay collections on English language and linguistics, on English and American literature and culture from the Middle Ages to the present, on the new English literatures, as well as on general and comparative literary studies, including aspects of cultural and literary theory.
This chapter suggests that OE pragmatics and discourse should be approached from a cross-linguist... more This chapter suggests that OE pragmatics and discourse should be approached from a cross-linguistic and cross-cultural perspective, rather than seeing Old English as a prestage for the later periods of English. It is its cultural and linguistic "otherness" which makes Old English, in spite of the lack of good data, a particularly interesting area for pragmatic study. The different culture(s) of the Anglo-Saxon world required forms for the negotiation of meaning different from those we are familiar with today. Thus the conspicuous lack of structures attesting to politeness as face work, the existence of distinct speech events such as flyting or the prominent role of silence allow cross-cultural and cross-linguistic comparison which both corroborates and challenges issues like the uniformitarian principle. Similarly, the different typological character of the morpho-syntax of Old English allows a degree of word order flexibility that is exploited by discourse strategies.
The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of... more The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of English philology. It publishes book-length studies and essay collections on English language and linguistics, on English and American literature and culture from the Middle Ages to the present, on the new English literatures, as well as on general and comparative literary studies, including aspects of cultural and literary theory
Lenker, Ursula. 2023. “‘And fare now wel …’: Functions of Imperatives in Middle English Verbal In... more Lenker, Ursula. 2023. “‘And fare now wel …’: Functions of Imperatives in Middle English Verbal Interaction”. In: Renate Bauer, Christine Elsweiler, Ulrike Krischke and Kerstin Majewski (eds.). Texts Travelling – Travelling Texts. A Gedenkschrift in Memory of Hans Sauer. München: utz, 2023, 123-141.
Yearbook of the German Cognitive Linguistics Association, Oct 1, 2020
Background: Sarcoidosis is a granulomatous disorder of unknown etiology. The term of immunoangios... more Background: Sarcoidosis is a granulomatous disorder of unknown etiology. The term of immunoangiostasis has been addressed by various studies as potentially involved in the disease pathogenesis. The aim of the study was to investigate the expression of the master regulator of angiogenesis hypoxia inducible factor (HIF)-1avascular endothelial growth factor (VEGF)-inhibitor of growth factor 4-(ING4)-axis within sarcoid granuloma. Methods: A total of 37 patients with sarcoidosis stages II-III were recruited in our study. Tissue microarray technology coupled with immunohistochemistry analysis were applied to video-assisted thoracoscopic surgery (VATS) lung biopsy samples collected from 37 sarcoidosis patients and 24 controls underwent surgery for benign lesions of the lung. Computerized image analysis was used to quantify immunohistochemistry results. qRT-PCR was used to assess HIF-1a and ING4 expression in 10 sarcoidosis mediastinal lymph node and 10 control lung samples. Results: HIF-1a and VEGF-ING4 expression, both in protein and mRNA level, was found to be downregulated and upregulated, respectively, in sarcoidosis samples compared to controls. Immunohistochemistry coupled with computerized image analysis revealed minimal expression of HIF-1a within sarcoid granulomas whereas an abundant staining of ING4 and VEGF in epithelioid cells was also visualized. Conclusions: Our data suggest an impairment of the HIF-1a-VEGF axis, potentialy arising by ING4 overexpression and ultimately resulting in angiostasis and monocyte recruitment within granulomas. The concept of immunoangiostasis as a possible protection mechanism against antigens of infectious origin needs further research to be verified.
At the end of the 2021 issues, Lucia Kornexl retired from the editorial board of Anglia. We very ... more At the end of the 2021 issues, Lucia Kornexl retired from the editorial board of Anglia. We very much hope that, despite this official farewell, her advice, help, knowledge and astute judgement will remain with us. Andrew James Johnston, whom we introduce to our readers in the following article, joins the editorial team of Anglia from the present volume. We would like to express our great sadness about the sudden deaths of two members of our advisory board: J. Hillis Miller passed away on February 7, 2021. Laura Marcus died on September 22, 2021. Both of them were exceptional scholars in their fields with a worldwide reputation. We are grateful for their service on our advisory board and shall miss them much.
The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of... more The Anglia Book Series (ANGB) offers a selection of high quality work on all areas and aspects of English philology. It publishes book-length studies and essay collections on English language and linguistics, on English and American literature and culture from the Middle Ages to the present, on the new English literatures, as well as on general and comparative literary studies, including aspects of cultural and literary theory.
This chapter suggests that OE pragmatics and discourse should be approached from a cross-linguist... more This chapter suggests that OE pragmatics and discourse should be approached from a cross-linguistic and cross-cultural perspective, rather than seeing Old English as a prestage for the later periods of English. It is its cultural and linguistic "otherness" which makes Old English, in spite of the lack of good data, a particularly interesting area for pragmatic study. The different culture(s) of the Anglo-Saxon world required forms for the negotiation of meaning different from those we are familiar with today. Thus the conspicuous lack of structures attesting to politeness as face work, the existence of distinct speech events such as flyting or the prominent role of silence allow cross-cultural and cross-linguistic comparison which both corroborates and challenges issues like the uniformitarian principle. Similarly, the different typological character of the morpho-syntax of Old English allows a degree of word order flexibility that is exploited by discourse strategies.
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