- I'm interested in the neural correlates of the processes we observe as working memory. I use a combination of investi... moreI'm interested in the neural correlates of the processes we observe as working memory. I use a combination of investigative techniques, including transcranial magnetic stimulation (TMS), fMRI and combined TMS-fMRI.edit
Previous studies have claimed that weak transcranial direct current stimulation (tDCS) induces persisting excitability changes in the human motor cortex that can be more pronounced than cortical modulation induced by transcranial magnetic... more
Previous studies have claimed that weak transcranial direct current stimulation (tDCS) induces persisting excitability changes in the human motor cortex that can be more pronounced than cortical modulation induced by transcranial magnetic stimulation, but there are no studies that have evaluated the effects of tDCS on working memory. Our aim was to determine whether anodal transcranial direct current stimulation, which enhances brain cortical excitability and activity, would modify performance in a sequential-letter working memory task when administered to the dorsolateral prefrontal cortex (DLPFC). Fifteen subjects underwent a three-back working memory task based on letters. This task was performed during sham and anodal stimulation applied over the left DLPFC. Moreover seven of these subjects performed the same task, but with inverse polarity (cathodal stimulation of the left DLPFC) and anodal stimulation of the primary motor cortex (M1). Our results indicate that only anodal stimulation of the left prefrontal cortex, but not cathodal stimulation of left DLPFC or anodal stimulation of M1, increases the accuracy of the task performance when compared to sham stimulation of the same area. This accuracy enhancement during active stimulation cannot be accounted for by slowed responses, as response times were not changed by stimulation. Our results indicate that left prefrontal anodal stimulation leads to an enhancement of working memory performance. Furthermore, this effect depends on the stimulation polarity and is specific to the site of stimulation. This result may be helpful to develop future interventions aiming at clinical benefits.
Research Interests: Engineering, Psychology, Cognitive Science, Depression, Chronic Pain, and 23 moreNeurophysiology, Multidisciplinary, Prefrontal Cortex, Executive Function, Perceptual Learning, Problem Solving, Ph, Cortex, Motor Cortex, Polarization, Cortical Plasticity, Task Performance, PLoS one, Transcranial Direct Current Stimulation, Brain Stimulation, Functional Neurology, Complex Problem Solving, General Intelligence, Primary Motor Cortex, Neurosciences, Region of Interest, Dorsolateral Prefrontal Cortex, and Intracortical Inhibition
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... apparent. The CE has multiple roles in processing information and co-ordinating the slave systems. The so-called * Correspondence to: Eva Feredoes, NPI, EuroaCentre, Prince of Wales Hospital, Sydney, NSW 2031, Australia. Tel ...
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Research Interests: Cognitive Science, Visual perception, Transcranial Magnetic Stimulation, Imagination, Humans, and 13 moreMental Imagery, Female, Male, Cortex, Mental rotation, Reaction Time, Posterior Parietal Cortex, Adult, Parietal Lobe, Left Hemisphere, Neurosciences, Functional Laterality, and Psychomotor Performance
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Research Interests:
Research Interests: Cognitive Control, Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, Working Memory, Face recognition (Psychology), and 14 moreMultidisciplinary, Prefrontal Cortex, Memory, Humans, Female, Male, Magnetic Resonance, Reaction Time, Verbal behavior, Verbal working memory, High Resolution, Inferior frontal gyrus, Proactive Interference, and Magnetic resonance image
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Research Interests: Psychology, Cognitive Science, Science Education, Individuality, Magnetic Resonance Imaging, and 22 moreTranscranial Magnetic Stimulation, Working Memory, Electroencephalography, Face recognition (Psychology), Cognitive Neuroscience, Recognition memory, Prefrontal Cortex, Dynamics, Humans, Evaluation methods, Female, Male, Reaction Time, Young Adult, Adult, Short Term Memory, Neurosciences, Repetitive transcranial magnetic stimulation, Proactive Interference, Functional Laterality, Psychomotor Performance, and Neuropsychological Tests
A common procedure for studying the effects on cognition of repetitive transcranial magnetic stimulation (rTMS) is to deliver rTMS concurrent with task performance, and to compare task performance on these trials versus on trials without... more
A common procedure for studying the effects on cognition of repetitive transcranial magnetic stimulation (rTMS) is to deliver rTMS concurrent with task performance, and to compare task performance on these trials versus on trials without rTMS. Recent evidence that TMS can have effects on neural activity that persist longer than the experimental session itself, however, raise questions about the assumption of the transient nature of rTMS that underlies many concurrent (or “online”) rTMS designs. To our knowledge, there have been no studies in the cognitive domain examining whether the application of brief trains of rTMS during specific epochs of a complex task may have effects that spill over into subsequent task epochs, and perhaps into subsequent trials. We looked for possible immediate spill-over and longer-term cumulative effects of rTMS in data from two studies of visual short-term delayed recognition. In 54 subjects, 10-Hz rTMS trains were applied to five different brain regions during the 3-s delay period of a spatial task, and in a second group of 15 subjects, electroencephalography (EEG) was recorded while 10-Hz rTMS was applied to two brain areas during the 3-s delay period of both spatial and object tasks. No evidence for immediate effects was found in the comparison of the memory probe-evoked response on trials that were vs. were not preceded by delay-period rTMS. No evidence for cumulative effects was found in analyses of behavioral performance, and of EEG signal, as a function of task block. The implications of these findings, and their relation to the broader literature on acute vs. long-lasting effects of rTMS, are considered.