Papers by David Rusin, Ph. D.
Pacific Journal of Mathematics, 1979
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Kitp Conference Applications of Gravitational Lensing Unique Insights into Galaxy Formation and Evolution, Oct 1, 2006
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Middle East Quarterly, Mar 1, 2013
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International Journal of Cancer, 1977
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Mathematics Magazine, 1980
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Journal of Algebra, 1992
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Journal of Algebra, 1980
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Discrete Mathematics, 1979
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Mathematics of Computation, 2003
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Mathematics of Computation, 2002
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Mathematics of Computation, 1989
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Journal of Pure and Applied Algebra, 1992
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Journal of Pure and Applied Algebra, 1987
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Journal of Pure and Applied Algebra, 1980
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New York J. Math, 1998
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Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 1991
Laparoscopic gastrostomy was performed successfully on six consecutive patients after the procedu... more Laparoscopic gastrostomy was performed successfully on six consecutive patients after the procedure was developed using a porcine model. These patients were unable to undergo percutaneous endoscopic gastrostomies because of obstruction from cancer or anatomical blockage. Operative time averaged less than 18 min. Three patients underwent the procedure under local anesthesia with intravenous sedation, and two patients were operated on in a strictly outpatient setting. No complications or deaths occurred. Laparoscopic gastrostomy appears to be a safe alternative to open gastrostomy in patients who cannot undergo percutaneous endoscopic gastrostomy.
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AIDS, 2007
We evaluated the safety, tolerability and antiretroviral activity of beta-D-2,6-diaminopurine dio... more We evaluated the safety, tolerability and antiretroviral activity of beta-D-2,6-diaminopurine dioxolane (DAPD; amdoxovir) with or without mycophenolate mofetil (MMF) in HIV-1 infection following extensive antiretroviral therapy (ART). Oral DAPD 500 mg twice daily with placebo or MMF 500 mg twice daily was added to failing ART. HIV-1 RNA viral load (VL) decline to week 2 was analyzed by intent-to-treat, using rank-based tests. Patients with VL decline > 0.5 log10 copies/ml at week 2 (virologic response, VR) optimized ART and continued therapy for up to 96 weeks. Forty adults with median VL 4.5 log10 copies/ml, median 184 CD4+ cells/microl, and a median of 6 nucleoside reverse transcriptase inhibitor (NRTI) mutations (range, 1-8) were randomized. Median VL reduction at week 2 was -0.26 log10 copies/ml (P < 0.0001). Response to DAPD/placebo (median -0.37 log10 copies/ml) was unexpectedly greater than to DAPD/MMF (median -0.23 log10 copies/ml), although this difference was not statistically significant (P = 0.59). MMF appeared to lower concentrations of DAPD and its metabolite dioxolane guanosine. Of 10 patients with VR (DAPD 7, DAPD/MMF 3), four persisted beyond week 24. VR was more frequent with < or = 5 baseline NRTI mutations (P = 0.12) or < 4 thymidine-associated mutations (TAMs) without E44D or V118I (P = 0.08). Twenty-three patients received extended DAPD +/- MMF; five beyond week 24. Few adverse events were related to study medications. The addition of DAPD +/- MMF to failing therapy appears safe and well tolerated. DAPD had significant activity at week 2 (mean -0.35 log10) in heavily pretreated patients that was not augmented by MMF.
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Proceedings of the International Astronomical Union, 2005
Gravitational lensing offers a potentially powerful tool for constraining the cosmological densit... more Gravitational lensing offers a potentially powerful tool for constraining the cosmological density parameters, particularly the cosmological constant (ΩΛ). This is accomplished by comparing the observed lensing rate with the predictions of various cosmologies. The recently completed Cosmic Lens All-Sky Survey (CLASS), the most ambitious and successful lens survey to date, gives us the raw materials we need to approach this problem -- a large well-defined and observationally unbiased radio sample that includes ˜20 new lens systems. The introduction of advanced analysis techniques is required to make the most of this data and assess the reliability of the derived cosmological constraints. Significant computational improvements are achieved with a more realistic representation of galaxy mass distributions. In previous analyses of lens surveys, it has been common to model galaxies as a population of non-evolving spherical (and sometimes singular) isothermal deflectors. This over-simplification can lead to large systematic errors in the predicted lensing rate. Here we present a series of advanced calculations of the lensing optical depth which includes the contributions of halo ellipticity, core radii and evolution of the galaxy luminosity function. We use these results to update constraints on ΩΛ from previous lens surveys, while setting the stage for a complete statistical analysis of CLASS.
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Proceedings of the International Astronomical Union, 2004
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Papers by David Rusin, Ph. D.