CCL25
| Hemokin (C-C motiv) ligand 25 | |
|---|---|
| Identifikatori | |
| Simbol | CCL25 |
| Alt. simboli | SCYA25, TECK, Ckb15 |
| Entrez | 6370 |
| HUGO | 10624 |
| OMIM | 602565 |
| RefSeq | NM_005624 |
| UniProt | O15444 |
| Drugi podaci | |
| Lokus | Hromozom 19 p13.2 |
CCL25, hemokin (C-C motiv) ligand 25, je mali citokin iz CC hemokin familije koji je takođe poznat kao TECK (timusom izražen hemokin). Za CCL25 se veruje da učestvuje u razvoju T-ćelija.[1] On je hemotaksan za timocite, makrofage, i dendritske ćelije. CCL25 destvuje vezivanjem za hemokinski receptor CCR9.[2][3] Ljudski CCL25 nastaje kao protein prekurzor koji sadrži 151 aminokiselina. CCL25 gen (scya25) je lociran na ljudskom hromozomu 19.[4][5]
- ↑ Vacari et al. (1997). „TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development”. Immunity 7: 291-301.
- ↑ Zaballos et al. (1999). „Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK”. J. Immunol. 162: 5671-5675.
- ↑ Gosling et al. (2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK”. J Immunol 164: 2851-6.
- ↑ Nomiyama et al. (1998). „The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2”. Genomics 51: 311-312.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.