CCL26
Izgled
Hemokin (C-C motiv) ligand 26 | |
---|---|
Identifikatori | |
Simbol | CCL26 |
Alt. simboli | SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 |
Entrez | 10344 |
HUGO | 10625 |
OMIM | 604697 |
PDB | 1G2T |
RefSeq | NM_006072 |
UniProt | Q9Y258 |
Drugi podaci | |
Lokus | Hromozom 7 q11.2 |
CCL26, hemokin (C-C motiv) ligand 26, je mali citokin iz CC hemokin familije koji je takođe poznat kao eotaksin-3, makrofagni inflamatorni protein 4-alfa (MIP-4-alfa), timusni stromalni hemokin-1 (TSC-1), i IMAC. On je izražen u više tkiva u srcu, plućima i jajnicima, i u endotelnim ćelijama nakon stimulacije sa citokinom IL-4.[1][2] CCL26 je hemotaksan za eozinofile i bazofile. On dejstvuje vezivanjem za hemokinski receptor CCR3 na ćelijskoj površini.[3] Gen ovog hemokina je lociran na ljudskom hromozomu 7.[4][5]
- ↑ Shinkai et al. (1999). „A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils”. J. Immunol. 163: 1602-1610.
- ↑ Guo et al. (1999). „Molecular cloning and characterization of a novel human CC chemokine, SCYA26”. Genomics 58: 313-317.
- ↑ Kitaura et al. (1999). „Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3”. J. Biol. Chem. 274: 27975-27980.
- ↑ Hillier et al. (2003). „The DNA sequence of human chromosome 7”. Nature 424: 157-164.
- ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.