Ibrahim A Abdelazim
Ain Shams University, Obstetrics and Gynecology, Faculty Member
- Professor of Obstetrics, Gynecology, Endoscopic Surgery and Reproductive Medicine, Ain Shams University, Cairo, Egypt... moreProfessor of Obstetrics, Gynecology, Endoscopic Surgery and Reproductive Medicine, Ain Shams University, Cairo, Egypt.
Consultant of Obstetrics, Gynecology and Endoscopic Surgery, Ahmadi Hospital, Kuwait Oil Company (KOC), Kuwait.
Visiting Professor in West Kazakhstan Medical University, Aktobe, Kazakhstan.
Certified Publons Academy Mentor, Supervisor and Reviewer.
Top 1% Peer Review Publons Award 2018.
Editorial Board Member of the BMC Series (BMC Womens` Health)
Editorial Board Member of the Gynecology, Obstetrics, Reproductive Medicine (GORM-Turkey).
Member of the European Society of Human Reproduction and Embryology (ESHRE)-E-13-00010.
International Reviewer and Researcher; More than One hundred published scientific researches and records cited through following links
Scopus Author ID: 36135469700
ResearcherID: F-7566-2013
ORCID: http://orcid.org/0000-0002-7241-2835
publons.com/a/433427/
PubMed link: https://www.ncbi.nlm.nih.gov/myncbi/1B5nTWjqdjekb/bibliography/public/
European PMC link: https://europepmc.org/authors/0000-0002-7241-2835#sthash.vtAij0kLedit
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Objectives The aim of this study was to assess the role of saline infusion hysterosonography (SIHS) in refining the diagnosis of uterine cavity abnormalities by hysteroscopy in infertile, asymptomatic women before IVF/intracytoplasmic... more
Objectives The aim of this study was to assess the role of saline infusion hysterosonography (SIHS) in refining the diagnosis of uterine cavity abnormalities by hysteroscopy in infertile, asymptomatic women before IVF/intracytoplasmic sperm injection (ICSI) treatment. Study design This was a comparative study carried out at the Ahmadi Hospital-Kuwait Oil Company during March 2010 to March 2012. Patients and methods A total of 124 asymptomatic, infertile women were included in this study before undergoing IVF/ICSI treatment. An informed consent and approval of the study protocol by the ethical committee of the institute was obtained. Hysteroscopy was performed as a routine procedure for uterine cavity assessment before the first attempt at IVF/ICSI treatment. The patients agreed to undergo an ultrasonographic assessment of the uterine cavity with the use of saline as the contrast medium (SIHS) besides hysteroscopic assessment. Both hysteroscopy and the SIHS procedure were scheduled after menstruation during the early-mid follicular phase of the same menstrual cycle, 1–3 months before starting the IVF/ICSI treatment. Results Uterine cavity abnormalities were detected in 40.3% of the patients included in this study before IVF/ICSI treatment (17.7% had endometrial polyps, 10.5% had submucosal fibroids, 4.8% had a uterine septum, 3.2% had uterine adhesions, 2.4% had endometrial hyperplasia, and 1.6% had a thin or atrophic endometrium). In this study, hysteroscopy was more sensitive (98 vs. 96.2%), specific (100 vs. 98.7%), and accurate (99.2 vs. 97.6%) compared with SIHS. Moreover, hysteroscopy had higher predictive values (100% positive predictive value and 98.7% negative predictive value vs. 98% positive predictive value and 97.4% negative predictive value) compared with SIHS during uterine cavity assessment before IVF/ICSI treatment.
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Background: The incidence of multiple gestations increased after the assisted reproductive techniques. Preterm labor and preterm premature rupture of fetal membranes are the most common complications of multiple gestations. Traditionally,... more
Background: The incidence of multiple gestations increased after the assisted reproductive techniques. Preterm labor and preterm premature rupture of fetal membranes are the most common complications of multiple gestations. Traditionally, if one fetus is delivered preterm in twin pregnancies, the situation is managed by delivery of the second fetus. Recently, there are reported cases of delayed-interval delivery (DID) of the second twin, with good outcome without established protocol for management of such cases. This report presents the protocol suggested by Abdelazim and Shikanova for the management of DID of the remaining second twin. Conclusion: The birth weight and the survival rate increased after Abdelazim and Shikanova suggested protocol for management of DID of the remaining second twin without any maternal risks or complications. DID should be done in tertiary centers after informing the parents about the possible risks of keeping the live second twin in the hostile intrauterine environment.
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Research Interests: Obstetrics, Medicine, Prospective studies, Pregnancy, Humans, and 15 moreFemale, Amniotic Fluid, Adult, Biological markers, Chorioamnionitis, Gestational Age, PROM, Sensitivity and Specificity, Gestation, Predictive value of tests, Case Control Studies, Premature Rupture of Membranes, Amniotic fluid index, Paediatrics and reproductive medicine, and Azo compounds
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To compare the efficacy and tolerability of heme-iron Optifer (HIO) versus intravenous (IV) iron saccharate/Ferosac in treatment of iron deficiency anemia (IDA) during pregnancy. Two hundred and thirty-six (236) women with moderate IDA... more
To compare the efficacy and tolerability of heme-iron Optifer (HIO) versus intravenous (IV) iron saccharate/Ferosac in treatment of iron deficiency anemia (IDA) during pregnancy. Two hundred and thirty-six (236) women with moderate IDA (hemoglobin > 7 and < 10 gm/dl) were included in this comparative multicenter study: 117 women in HIO/Optifer group and 119 women in IV/Ferosac group. Women in HIO/Optifer group received Optifer tablets twice daily till hemoglobin level of 11–12 gm/dl then once daily (maintenance dose). Total IV iron dose calculated for the studied women in the IV/Ferosac group according to the manufacturer instructions. The pre-treatment ferritin, hemoglobin (Hb), RBCs-mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) were compared by post-treatment values in the two studied groups. The mean post-treatment Hb and ferritin were similar with no significant difference between HIO/Optifer group and IV/Ferosac group (11.7 ± 5.5 gm/dl and 118.8 ± 66.9 μg/l, respectively, versus 12.4 ± 6.1 and 132.9 ± 75.3, respectively), (P = 0.87 and 0.89, respectively). The mean post-treatment MCV and MCH were similar with no significant difference between HIO/Optifer group and IV/Ferosac group (94.0 ± 7.2 fl and 29.4 ± 2.9 pg, respectively, versus 97.7 ± 6.6 and 31.7 ± 4.2, respectively), (P = 0.17 and 0.99, respectively). The HIO/Optifer is an effective, well tolerable oral iron for treatment of moderate IDA during pregnancy with similar efficacy to IV iron saccharate/Ferosac. The IV iron saccharate/Ferosac is safe and an effective alternative to heme-iron for treatment of moderate IDA in women presented with IDA at later gestation when rapid replacement of iron stores required.
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The most common sutures used for uterine suturing during cesarean section (CS) are vicryl and/or chromic catgut. The sutures' chemistry and polymer morphology alter sutures' performance and absorption. If the sutures used during... more
The most common sutures used for uterine suturing during cesarean section (CS) are vicryl and/or chromic catgut. The sutures' chemistry and polymer morphology alter sutures' performance and absorption. If the sutures used during CS undergo inappropriate hydrolysis and absorption, the retained intrauterine sutures may cause intrauterine inflammations with subsequent abnormal uterine bleeding (AUB) and/or infertility. This report represents a rare case report of retained intrauterine sutures for 6 years after previous CS, which were incised and released from its attachment to the uterine wall using operative hysteroscopy. This report highlights that the retained intrauterine sutures may interfere with sperm transport and implantation and act as a foreign body with subsequent intrauterine inflammation and infertility. In addition, the report highlights the role of a hysteroscopy as the gold standard for uterine cavity assessment in women presented with AUB and/or infertility.
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Spontaneous; Cornual; Pregnancy; Salpingectomy; Tubal.
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Objective This prospective study was designed to evaluate the outcome and the changes in uterine artery blood flow after thermal balloon endometrial ablation (TBEA) in cases of menorrhagia. Study design Prospective study. Patients and... more
Objective This prospective study was designed to evaluate the outcome and the changes in uterine artery blood flow after thermal balloon endometrial ablation (TBEA) in cases of menorrhagia. Study design Prospective study. Patients and methods Eighty-two premenopausal women with menorrhagia were included in this study. The TBEA was carried out on cycle days 3–8. Transvaginal color Doppler measurements were obtained from the uterine arteries on both sides before ablation and repeated on the first day, 3, 6, and 12 months after TBEA. Results Of 82 women, 78 (95.12%) were satisfied and experienced improvement after TBEA. The end-diastolic velocity was significantly decreased 6 and 12 months after TBEA (5.0±2.5 and 4.6±3.0; respectively); also, the time-averaged maximum velocity was significantly decreased 6 and 12 months after TBEA (14.8±3.4 and 13.9±3.4, respectively). The pulsatility index was significantly increased 6 and 12 months after TBEA (1.6±0.9 and 1.63±0.8, respectively); also, the resistance index was significantly increased 6 and 12 months after TBEA (0.89±0.2 and 0.90±0.3, respectively). Conclusion TBEA induces increase in impedance of the uterine blood flow because of fibrosis in the endometrium and subendometrial layers, with a subsequent reduction in the menstrual flow.
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Abstract Objective To detect the prevalence of metabolic syndrome (MS) among infertile women with polycystic ovary syndrome (PCOS). Methods Two hundred and twenty infertile PCOS women were included in this prospective cross section study.... more
Abstract Objective To detect the prevalence of metabolic syndrome (MS) among infertile women with polycystic ovary syndrome (PCOS). Methods Two hundred and twenty infertile PCOS women were included in this prospective cross section study. Diagnosis of PCOS was based on at least two of ESHRE/ASRM criteria and diagnosis of MS was based on at least three of NCEP ATP III criteria. A standard questionnaire was used to document length of menstrual cycles, personal and family history of medical disorders. Signs of androgen excess and insulin resistance were noted in the physical examination. Anthropometric measurements were done to measure waist circumference, hip circumference and body mass index (BMI) was calculated. Overnight fasting blood sample and a 75 gram oral glucose tolerance test, TSH, prolactin, total testosterone, SHBG and lipid profile levels were evaluated in all studied PCOS women. Trans-vaginal ultrasound was also done to measure; ovarian volume and number of follicles in both ovaries. Results The prevalence of MS in studied PCOS women was 30.5% (67/220). There is strong positive correlation between prevalence of MS and both age and BMI of the studied PCOS women. Logistic regression analysis showed that; the age > 25 and waist-hip ratio ⩾ 0.85 were powerful predictors for the prevalence of MS in PCOS women. Conclusion The prevalence of MS was 30.5% in the studied PCOS women. The age above 25 years and waist-hip ratio ⩾ 0.85 were powerful predictors for prevalence of MS in PCOS women.
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Objectives: To compare insulin-like growth factor binding protein-1/alpha-fetoprotein (IGFBP-1/AFP) to placental alpha microglobulin-1 (PAMG-1) for diagnosis of premature fetal membranes rupture (PROM). Methods: 220 pregnant women ≥ 37... more
Objectives: To compare insulin-like growth factor binding protein-1/alpha-fetoprotein (IGFBP-1/AFP) to placental alpha microglobulin-1 (PAMG-1) for diagnosis of premature fetal membranes rupture (PROM). Methods: 220 pregnant women ≥ 37 and <39 weeks gestation studied and classified into two groups; study group (PROM) and control group (no PROM). Examination of the studied women followed by abdominal ultrasound (TAS) and sterile vaginal speculum examination to visualize amniotic fluid leaking and for collection of samples for fern, nitrazine, AmniSure® and AmnioQuick® Duo+ tests on admission. Results: The sensitivity and specificity of AmnioQuick® Duo+ test to detect PROM was 93.6% and 86.4%; respectively compared to 95.5% and 89.1%; respectively for AmniSureR test, 72.7% and 80.9%; respectively for fern test and 76.4% and 83.6%; respectively for nitrazine test. PPV, NPV and accuracy of AmnioQuick® Duo+ test to detect PROM were 87.3%, 93.1% and 90%; respectively compared to 89.7, 95.1% and 92.3%; respectively for AmniSureR test, 79.2%, 74.8% and 76.8%; respectively for fern test and 82.4%, 77.97% and 80%; respectively for nitrazine test. AmnioQuick® Duo+ and AmniSure® tests had higher sensitivity, specificity, predictive values and accuracy to detect PROM compared to conventional diagnostic tests. Conclusion: AmnioQuick® Duo+ test for detection of IGFBP-1/AFP was rapid, accurate bedside test better than the individual conventional diagnostic tests and has same accuracy and performance like AmniSure® test.
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An increasing number of reports describe the delayed second twin delivery for days, or weeks with good results in the majority of the cases, and different survival rate between centers, without reported randomized controlled trials... more
An increasing number of reports describe the delayed second twin delivery for days, or weeks with good results in the majority of the cases, and different survival rate between centers, without reported randomized controlled trials (RCTs). This study was designed to evaluate the suggested management of the delayed second twin delivery in the Sabah Maternity Hospital regarding its outcome, possible risks, and benefits. Forty-seven twin pregnancies with preterm labor (PTL) of the first fetus between 20-30 weeks, and delayed delivery of the second twin were included in this study. Studied women signed informed consent about the possible risks of keeping the live fetus in the hostile intrauterine environment, and benefits of the prolonged gestation for the second twin. Throughout the conservative treatment of the second twin, the studied women were hospitalized with regular follow up for infections, consumptive coagulopathy parameters, and wellbeing of the second twin. There was significant difference in the gestational age at delivery between the first and second twin (22.6 ± 3.4 versus 34.3 ± 2.5 weeks; respectively, p = .01). There was significant difference in the birth weight between the first and second twin (435 ± 91.2 versus 1472 ± 61.5 g; respectively, p = .004). The rate of the cesarean delivery was significantly high during delivery of the second twin compared with the first twin (23.4% (11/47) versus 0% (0/47); respectively, p = .0001) with high survival rate for the second twin (85.1% (40/47)) after the delayed second twin delivery. The birth weight, the gestational age, and the survival rate of the studied second twin significantly increased after the suggested management of the delayed second twin delivery.
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Abstract Objective To detect the role of magnetic resonance imaging in refining the diagnosis of suspected fetal renal anomalies detected during screening sonography. Methods 54 pregnant women, with suspected fetal renal anomalies... more
Abstract Objective To detect the role of magnetic resonance imaging in refining the diagnosis of suspected fetal renal anomalies detected during screening sonography. Methods 54 pregnant women, with suspected fetal renal anomalies detected during routine ultrasound screening, were rescanned by MRI to refine the diagnosis of the suspected renal anomalies. The pregnancy outcome was examined externally and by postnatal ultrasonography. Results 54 cases of suspected renal anomalies detected during screening sonography of 8 400 pregnant women (0.6%), were rescanned by MRI in this study. The MRI diagnosed, 29 (53.7%) cases of parenchymal renal disease, 20 (37.0%) cases of hydronephrosis, 3 (5.6%) cases of single renal cyst and 2 (3.7%) cases of megacystis + hydroureter. The amniotic fluid volume was normal in 33 (61.0%) cases, while it was decreased in 21 (39.0%) cases. Two cases of chromosomal aberration (3.7%) were detected in the studied cases. During antenatal follow up of the prenatal diagnosed cases with renal anomalies 2 cases of bilateral RA (Potter's syndrome died in utero = IUFD) and out of 52 live births 1 case of NND occurred due to bilateral MCKD with trisomy 18. In this study, when the prenatal findings were compared with the postnatal findings, the MRI was 89.5% accurate, while the prenatal ultrasound was 85% accurate in diagnosing fetal renal anomalies. Conclusion The MRI can be used as a complementary adjunctive modality with excellent tissue contrast especially in equivocal cases or inconclusive sonographic findings.
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The cesarean sections (CSs) rates increased worldwide (32.9% in the United States 2009). CS scar dehiscence (CSSD) is one of the complications encountered after cesarean delivery due to disruption of the scar tissue of the previous CS.... more
The cesarean sections (CSs) rates increased worldwide (32.9% in the United States 2009). CS scar dehiscence (CSSD) is one of the complications encountered after cesarean delivery due to disruption of the scar tissue of the previous CS. CSSD is a risk factor of uterine rupture during trial of labor after previous CS. A 32-year-old woman, previous 3 CSs, admitted to the Obstetrics and Gynecology department of Ahmadi hospital, Kuwait, for elective CS. During the elective CS, the scars of previous CSs were complete dehiscent through its whole length with missing anterior uterine wall leaving visible fetal membranes underneath. This report represents a case of complete CSSD encountered during elective CS and the suggested I. Abdelazim technique for repair of dehiscent previous cesarean section scars encountered during elective CSs.
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Congenital dacryocystoceles are usually diagnosed in the third trimester by parental ultrasound as a cystic lesion adjacent to the medial and inferior aspects of the fetal orbit. A considerable number of dacryocystocele are bilateral and... more
Congenital dacryocystoceles are usually diagnosed in the third trimester by parental ultrasound as a cystic lesion adjacent to the medial and inferior aspects of the fetal orbit. A considerable number of dacryocystocele are bilateral and resolve spontaneously in utero and/or immediately after delivery. Persistent dacryocystoceles need ophthalmological consultation to avoid the possible potential complications. This case report represents a case of congenital dacryocystocele diagnosed by antenatal 2D and 3D ultrasounds, which disappeared spontaneously 2 days after birth. To highlight that, the diagnosis of congenital dacryocystoceles is important to avoid additional postnatal diagnostic techniques and to manage the potential postnatal complications.
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Research Interests: Biomedical Engineering, Obesity, Medicine, Humans, Hemodynamics, and 15 moreFemale, Anesthesia, Propofol, Length of Stay, Clinical Sciences, General Anesthesia, Middle Aged, Adult, Postoperative Period, Postoperative Complications, Remifentanil, Pulmonary function testing, pacu, Respiratory function tests, and discontinuation
This study was designed to compare sequential clomiphene citrate/hMG regimen to hMG regimen for ovulation induction in clomiphene citrate-resistant women. A comparative prospective study. Ninety infertile women were randomized to receive... more
This study was designed to compare sequential clomiphene citrate/hMG regimen to hMG regimen for ovulation induction in clomiphene citrate-resistant women. A comparative prospective study. Ninety infertile women were randomized to receive either sequential CC/hMG regimen (45 women) or low-dose step-up protocol of hMG (45 women). All participants had received at least six consecutive cycles of clomiphene citrate for ovulation induction within the last year before inclusion in this study, but they did not conceive. The CC/hMG regimen group received clomiphene citrate 100 mg/day for 5 days, followed by hMG 75 IU for 4 days. The hMG group received low-dose step-up protocol for 10-14 days. To detect the number and size of the follicles, TVS was done on cycle day 8 and repeated daily or every other day according to follicular development. When one to three follicles reached a diameter ≥18 mm, hCG injection was scheduled. Before hCG injection, the E2 level and endometrial thickness were evaluated. β-hCG levels were measured on cycle day 22. There was no significant difference between the two studied groups regarding the demographic data, sperm parameters, and day 3 FSH, LH and estradiol. Also, there was no significant difference between the two studied groups regarding endometrial thickness, number of mature follicles, peak of E2 before hCG injection and number of cases that developed ovarian cyst or OHSS. The dose of gonadotropins used was significantly low in the CC/hMG group compared to the hMG group (295.2 ± 75.5 vs. 625.3 ± 65.0, respectively), and the pregnancy rate was significantly high in the CC/hMG group compared to the hMG group [12 (26.7 %) vs. 3 (6.7 %), respectively, p &amp;amp;lt; 0.05]. The sequential CC/hMG regimen is as effective as hMG regimen for ovulation induction, produces satisfactory pregnancy results and reduces the treatment cost.
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Research Interests: Obstetrics, Medicine, Pregnancy, Humans, Colonisation, and 12 moreFemale, Polymerase Chain Reaction, Sepsis, Vagina, Public health systems and services research, Streptococcus, Neonatal Sepsis, Streptococcus agalactiae, Parturition, Sensitivity and Specificity, Paediatrics and reproductive medicine, and Streptococcal infections
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Objective: The aim of this study was to detect the effect of vitamin D (Vit. D) intake on the mid-luteal estradiol (E2), and progesterone (P), and the relation between vit. D, and the adolescents' mid-luteal E2, and P. Patients and... more
Objective: The aim of this study was to detect the effect of vitamin D (Vit. D) intake on the mid-luteal estradiol (E2), and progesterone (P), and the relation between vit. D, and the adolescents' mid-luteal E2, and P. Patients and methods: Eighty-five (85) adolescents were recruited for this cohort study after obtaining informed consent. After a detailed history and clinical examination, the body mass index (BMI) of the studied participants was calculated, followed by pelvic sonography to exclude any pelvic pathology. Participants' blood samples were collected on days 21-22 of the menstrual cycle (mid-luteal) to measure the thyrotropin (TSH) (i.e., to exclude hypothyroidism), prolactin (i.e., to exclude hyperprolactinemia), glycosylated hemoglobin (HbA1C), (i.e., to exclude diabetes), E2, P, and 25(OH)D. Participants received 50,000 IU of vit. D weekly for two months, and on the 3rd month, the mid-luteal E2, P, and 25(OH)D were measured. The mid-luteal E2, P, and 25(OH)D were compared before and after the vit. D intake to detect the effect of vit. D intake (50,000 IU weekly for 2 months) on the mid-luteal E2 and P (primary outcome). Additionally, the relations between vit. D and the adolescents' mid-luteal E2 and P were detected as secondary outcomes using the correlation analysis (Pearson's correlation). Results: The mid-luteal E2 and P statistically decreased from 109.3±15.7 pg/mL and 9.8±1.01 ng/mL, respectively to 40.7±10.52 pg/mL, and 5.2±0.73 ng/mL, respectively, after vit. D intake (p=0.00015; 95% CI: 64.5, 68.6, 72.7, and p=0.0016; 95% CI: 4.3, 4.6, 4.87, respectively). Significant negative correlations between the 25(OH)D, and both the mid-luteal E2 (r -0.661; p<0.00001), and P (r -0.521; p<0.00001) were detected in this study. Conclusions: The mid-luteal E2 and P statistically decreased after vit. D intake (50,000 IU of vit. D weekly for 2 months). Significant negative correlations between the 25(OH)D, and both the mid-luteal E2 and P were detected in this study. The relation between vit. D and ovarian steroids, and the effect of vit. D intake on ovarian steroids need further larger studies.