Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation o... more Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation of ultrashort laser pulse propagation in air are investigated. Linear analyses and numerical results show that these two saturable nonlinear effects can destroy the coherent evolution of the laser field, and small-scale spatial turbulent structures rapidly appear. For the two-dimensional case, numerical simulations show that blow-up-like solutions, spatial chaos, and pseudorecurrence can appear at higher laser intensities if only plasma defocusing is included. These complex patterns result from the stochastic evolution of the higher- or shorter-wavelength modes of the laser light spectrum. From the viewpoint of nonlinear dynamics, filamentation can be attributed to the modulational instability of these spatial incoherent localized structures. Furthermore, filament patterns associated with multiphoton ionization of the air molecules with and without higher-order Kerr effects are compared.
World journal of gastroenterology : WJG, Jan 28, 2014
To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clini... more To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120 blood specimens and 120 intestinal tract tissue specimens collected from patients with neoplastic intestinal polyps. In the control group I there were 80 blood specimens and 80 intestinal tract tissue specimens collected from patients with colorectal cancer. In the control group II there were 40 blood specimens and 40 intestinal tract tissue specimens collected from healthy individuals. The gene segments were amplified using PCR and DNA gel electrophoresis along with DNA sequence analysis were employed for the detection of the following single nucleotide polymorphisms (SNPs): K-RAS codons 12 and 13; hMLH1 (human mutS homolog 1) gene missense mutation at Va1384Asp; hMSH2 (human mut...
Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and de... more Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8) protected mice against the lethal schistosome infection through the attenuation of hepatic fibrosis. We demonstrated an additive role of IL-13 and TGF-β1 in up-regulating the miR-21 expression in the hepatic stellate cells (HSCs) by activation of the SMAD proteins. Further, the down-regulation of miR-21 in the HSCs reversed hepatic fibrosis by enhancing SMAD7 expression, thus repressing TGF-β1/Smad and IL-13/Smad pathways. Conclusion: Our study revealed the mechanism of IL-13-mediated schistosomiasis hepatic fibrosis by up-regulation of miR-21 and highlights the potential of r...
ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investiga... more ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investigated. Based upon reversibility of the Jacobian matrix and matrix theory, we carry out a series of elementary column transformations to Jacobian matrix. And then, according to Lyapunov function theory, sufficient conditions for generalized synchronization between drive system and response system with different dimensions are obtained. Numerical simulations are also given to demonstrate the effectiveness of the proposed scheme.
ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The lo... more ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The local stability of hyperbolic equilibrium and non-hyperbolic equilibrium are investigated by using center manifold theorem. Pitchfork bifurcation, degenerate pitchfork bifurcation and Hopf bifurcation are analyzed when the parameters are varied in the space of parameter. For a suitable choice of the parameters, the existence of singularly degenerate heteroclinic cycles and Hopf bifurcation without parameters are also investigated. Some numerical simulations are given to support the analytic results.
International Journal of Control Automation and Systems, 2013
ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based... more ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based Chua’s oscillator and presents the oscillator as the T-S fuzzy model system. Based on Lyapunov stability theory, we design an intermittent controller to guarantee the stability of the chaotic system. Simulation results are presented to verify the effectiveness of the method.
The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play importan... more The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play important roles in hematopoiesis regulation, lymphocyte activation, and trafficking, as well as in developmental processes, including organogenesis, vascularization, and embryogenesis. The receptor is also involved in HIV infection and tumor growth and metastasis. Antagonists of CXCR4 have been widely evaluated for drugs against HIV and tumors. In an effort to identify novel CXCR4 antagonists, we screened a small library of compounds derived from marine organisms and found bryostatin-5, which potently inhibits chemotaxis induced by SDF-1 in Jurkat cells. Bryostatin-5 is a member of the macrolactones, and its analogue bryostatin-1 is currently being evaluated in clinical trials for its chemotherapeutic potential. The involvement of bryostatins in the SDF-1/CXCR4 signaling process has never been reported. In this study, we found that bryostatin-5 potently inhibits SDF-1-induced chemotaxis but does...
International journal of oral and maxillofacial surgery, 2010
The aim of this retrospective study was to correlate the width of the cleft lip with the severity... more The aim of this retrospective study was to correlate the width of the cleft lip with the severity of the nasal deformity in unilateral cleft lip and palate (UCLP) patients before primary lip repair. Preoperative impression casts were made. Measurements were taken of the width of the cleft lip (CW), nose (NW), and nasal floor (NFW), alar base height (ABH), columella length (CL), nasal length (NL) and nasal tip protrusion (NTP). The ratio of the non-cleft side (NFW) to the cleft side (NFWR), the ratio of the non-cleft side (ABH) to the cleft side (ABHR), and the ratio of the cleft side (CL) to the non-cleft side (CLR) were calculated. The average NW, NL and CW were higher in the group with complete clefts. There was a negative linear relationship between CW and NFWR, and a positive linear relationship between CW and ABHR in the complete group. In the incomplete group, negative correlations were obtained between CW and NFWR and between CW and ABHR. These findings show that there are co...
Schistosomiasis japonica is a serious tropical parasitic disease in humans, which causes inflamma... more Schistosomiasis japonica is a serious tropical parasitic disease in humans, which causes inflammation and fibrosis of the liver. Hepatic stellate cells (HSCs) are known to play an important role in schistosome-induced fibrosis, but their role in schistosome-induced inflammation is still largely unknown. Here, we use a murine model of schistosomiasis japonica to investigate the role that nuclear factor kappa B (NF-κB), a critical mediator of inflammatory responses, plays in schistosome-induced inflammation. We revealed that NF-κB was significantly activated in HSCs at the early stage of infection, but not at later stages. We also show that the expression levels of several chemokines regulated by NF-κB signaling (Ccl2, Ccl3 and Ccl5) were similarly elevated at early infection. TLR4 signaling, one of the strongest known inducers of NF-κB activation, seemed not activated in HSCs post-infection. Importantly, we found that levels of miR-146 (a known negative regulator of NF-κB signaling) in HSCs opposed those of NF-κB signaling, elevating at later stage of infection. These results indicate that HSCs might play an important role in the progression of hepatic schistosomiasis japonica by linking liver inflammation to fibrosis via NF-κB signaling. Moreover, our work suggests that miR-146 appeared to regulate this process. These findings are significant and imply that manipulating the function of HSCs by targeting either NF-κB signaling or miR-146 expression may provide a novel method of treating hepatic schistosomiasis japonica.
Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation o... more Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation of ultrashort laser pulse propagation in air are investigated. Linear analyses and numerical results show that these two saturable nonlinear effects can destroy the coherent evolution of the laser field, and small-scale spatial turbulent structures rapidly appear. For the two-dimensional case, numerical simulations show that blow-up-like solutions, spatial chaos, and pseudorecurrence can appear at higher laser intensities if only plasma defocusing is included. These complex patterns result from the stochastic evolution of the higher- or shorter-wavelength modes of the laser light spectrum. From the viewpoint of nonlinear dynamics, filamentation can be attributed to the modulational instability of these spatial incoherent localized structures. Furthermore, filament patterns associated with multiphoton ionization of the air molecules with and without higher-order Kerr effects are compared.
World journal of gastroenterology : WJG, Jan 28, 2014
To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clini... more To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120 blood specimens and 120 intestinal tract tissue specimens collected from patients with neoplastic intestinal polyps. In the control group I there were 80 blood specimens and 80 intestinal tract tissue specimens collected from patients with colorectal cancer. In the control group II there were 40 blood specimens and 40 intestinal tract tissue specimens collected from healthy individuals. The gene segments were amplified using PCR and DNA gel electrophoresis along with DNA sequence analysis were employed for the detection of the following single nucleotide polymorphisms (SNPs): K-RAS codons 12 and 13; hMLH1 (human mutS homolog 1) gene missense mutation at Va1384Asp; hMSH2 (human mut...
Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and de... more Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8) protected mice against the lethal schistosome infection through the attenuation of hepatic fibrosis. We demonstrated an additive role of IL-13 and TGF-β1 in up-regulating the miR-21 expression in the hepatic stellate cells (HSCs) by activation of the SMAD proteins. Further, the down-regulation of miR-21 in the HSCs reversed hepatic fibrosis by enhancing SMAD7 expression, thus repressing TGF-β1/Smad and IL-13/Smad pathways. Conclusion: Our study revealed the mechanism of IL-13-mediated schistosomiasis hepatic fibrosis by up-regulation of miR-21 and highlights the potential of r...
ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investiga... more ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investigated. Based upon reversibility of the Jacobian matrix and matrix theory, we carry out a series of elementary column transformations to Jacobian matrix. And then, according to Lyapunov function theory, sufficient conditions for generalized synchronization between drive system and response system with different dimensions are obtained. Numerical simulations are also given to demonstrate the effectiveness of the proposed scheme.
ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The lo... more ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The local stability of hyperbolic equilibrium and non-hyperbolic equilibrium are investigated by using center manifold theorem. Pitchfork bifurcation, degenerate pitchfork bifurcation and Hopf bifurcation are analyzed when the parameters are varied in the space of parameter. For a suitable choice of the parameters, the existence of singularly degenerate heteroclinic cycles and Hopf bifurcation without parameters are also investigated. Some numerical simulations are given to support the analytic results.
International Journal of Control Automation and Systems, 2013
ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based... more ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based Chua’s oscillator and presents the oscillator as the T-S fuzzy model system. Based on Lyapunov stability theory, we design an intermittent controller to guarantee the stability of the chaotic system. Simulation results are presented to verify the effectiveness of the method.
The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play importan... more The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play important roles in hematopoiesis regulation, lymphocyte activation, and trafficking, as well as in developmental processes, including organogenesis, vascularization, and embryogenesis. The receptor is also involved in HIV infection and tumor growth and metastasis. Antagonists of CXCR4 have been widely evaluated for drugs against HIV and tumors. In an effort to identify novel CXCR4 antagonists, we screened a small library of compounds derived from marine organisms and found bryostatin-5, which potently inhibits chemotaxis induced by SDF-1 in Jurkat cells. Bryostatin-5 is a member of the macrolactones, and its analogue bryostatin-1 is currently being evaluated in clinical trials for its chemotherapeutic potential. The involvement of bryostatins in the SDF-1/CXCR4 signaling process has never been reported. In this study, we found that bryostatin-5 potently inhibits SDF-1-induced chemotaxis but does...
International journal of oral and maxillofacial surgery, 2010
The aim of this retrospective study was to correlate the width of the cleft lip with the severity... more The aim of this retrospective study was to correlate the width of the cleft lip with the severity of the nasal deformity in unilateral cleft lip and palate (UCLP) patients before primary lip repair. Preoperative impression casts were made. Measurements were taken of the width of the cleft lip (CW), nose (NW), and nasal floor (NFW), alar base height (ABH), columella length (CL), nasal length (NL) and nasal tip protrusion (NTP). The ratio of the non-cleft side (NFW) to the cleft side (NFWR), the ratio of the non-cleft side (ABH) to the cleft side (ABHR), and the ratio of the cleft side (CL) to the non-cleft side (CLR) were calculated. The average NW, NL and CW were higher in the group with complete clefts. There was a negative linear relationship between CW and NFWR, and a positive linear relationship between CW and ABHR in the complete group. In the incomplete group, negative correlations were obtained between CW and NFWR and between CW and ABHR. These findings show that there are co...
Schistosomiasis japonica is a serious tropical parasitic disease in humans, which causes inflamma... more Schistosomiasis japonica is a serious tropical parasitic disease in humans, which causes inflammation and fibrosis of the liver. Hepatic stellate cells (HSCs) are known to play an important role in schistosome-induced fibrosis, but their role in schistosome-induced inflammation is still largely unknown. Here, we use a murine model of schistosomiasis japonica to investigate the role that nuclear factor kappa B (NF-κB), a critical mediator of inflammatory responses, plays in schistosome-induced inflammation. We revealed that NF-κB was significantly activated in HSCs at the early stage of infection, but not at later stages. We also show that the expression levels of several chemokines regulated by NF-κB signaling (Ccl2, Ccl3 and Ccl5) were similarly elevated at early infection. TLR4 signaling, one of the strongest known inducers of NF-κB activation, seemed not activated in HSCs post-infection. Importantly, we found that levels of miR-146 (a known negative regulator of NF-κB signaling) in HSCs opposed those of NF-κB signaling, elevating at later stage of infection. These results indicate that HSCs might play an important role in the progression of hepatic schistosomiasis japonica by linking liver inflammation to fibrosis via NF-κB signaling. Moreover, our work suggests that miR-146 appeared to regulate this process. These findings are significant and imply that manipulating the function of HSCs by targeting either NF-κB signaling or miR-146 expression may provide a novel method of treating hepatic schistosomiasis japonica.
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