Rauvolscin

Rauvolscin
IUPAC ime
	metil estar 17α-hidroksi-20α-johimban-16β-karboksilne kiseline
Klinički podaci
Način primene	Oralno
Pravni status
Pravni status	Nije kontrolisan;
Identifikatori
CAS broj	131-03-3 6211-32-1 (HCl)
ATC kod	none
PubChem	CID 643606
IUPHAR/BPS	136
ChemSpider	558737
ChEBI	CHEBI:48562
ChEMBL	CHEMBL10347
Hemijski podaci
Formula	C21H26N2O3
Molarna masa	354,44 g/mol
	InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1 ; Key:BLGXFZZNTVWLAY-DIRVCLHFSA-N ;

Rauvolscin (izojohimbin, α-johimbin, i korinantidin) je alkaloid koji je prisutan kod više vrsta biljki iz rodova Rauwolfia i Pausinystalia.^[1] On je stereoizomer johimbina.^[1] Rauvolscin je stimulant centralnog nervnog sistema, lokalni anestetik i u izvesnoj meri afrodizijak.^[1]

Reference

^ ^а ^б ^в KOHLI JD, DE NN (1956). „Pharmacological action of rauwolscine”. Nature. 177 (4521): 1182. PMID 13334509. doi:10.1038/1771182a0.
^ Perry BD, U'Prichard DC (1981). „[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors”. European Journal of Pharmacology. 76 (4): 461—4. PMID 6276200. doi:10.1016/0014-2999(81)90123-0.
^ Arthur JM, Casañas SJ, Raymond JR (1993). „Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors”. Biochemical Pharmacology. 45 (11): 2337—41. PMID 8517875. doi:10.1016/0006-2952(93)90208-E.
^ Kaumann AJ (1983). „Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors”. Naunyn-Schmiedeberg's Archives of Pharmacology. 323 (2): 149—54. PMID 6136920. doi:10.1007/BF00634263.
^ Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (1998). „[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor”. Naunyn-Schmiedeberg's Archives of Pharmacology. 357 (1): 17—24. PMID 9459568. doi:10.1007/PL00005133. Архивирано из оригинала 11. 09. 2001. г. Приступљено 18. 08. 2012.