HLA studies in Crete show that this population is related to North Africans and also Iberians. Th... more HLA studies in Crete show that this population is related to North Africans and also Iberians. This may be a reflection of a common prehistoric first Europeans relationships with North Africans and drying Saharan emigration after 10,000 years BC; it may be specifically represented by a primitive and early cult to the bull in both Cretan (Minoan) and Iberian populations. In the present study, unrelated Cretans representing different Island parts have been studied for class II HLA-DRB1 and-DQB1 alleles. The most frequent ones were HLA-DRB1*11:01 and HLA-DRB1*07:01 and HLA-DQB1*03:01 and DQB1*05:01. Also, the Cretan HLA class II haplotype HLA-DBR1*11:01-DQB1*03:01 had the highest frequency and is also common to other Mediterraneans, including Iberians. In addition, DRB1*07:01-DQB1*02:01 and HLA-DRB1*04:02-DQB1*03:02 Cretan haplotypes are shared with North Africans (the latter with Algerians, Tunisians and Moroccans). In summary, Crete was one of the first European classic cultures (Minoan) which was probably an early link, like Iberia, between North Africa /Sahara and Europe,also supported by genetic results.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
The myth of The Abduction or Rape of Europa tells that a Middle East aristocrat (princess) was ab... more The myth of The Abduction or Rape of Europa tells that a Middle East aristocrat (princess) was abducted by Zeus (gods father in Greek mythology) disguised as a white bull. The Bull-Zeus took Europa to Crete (Zeus birth place) and Europa became as the the first Creta Queen. Minos was one of the Zeus and Europa sons. He was a legendary Cretan King who kept the Minotaur a monster man with a bull head in a labyrinth. Some authors maintain that the Minotaur was a direct son of Europa and the Bull-Zeus. Crete was imposing Athens to offer young people that were left in the labyrinth and eaten by the Minotaur. Finally, Theseus, founder of Athens and Attica killed the Minotaur and freed Athens from being submitted. On the other hand, Cretan Lineal B was later discovered as Greek language; Cretan Lineal A (Minoan) is possible a Lineal B and Greek language precursor. Also, laws from Crete were taken to continental Sparta by Lycurgus. Crete genetics and bull culture are closer to Iberians than to other Europeans. This Europa myth was very popular all along classical Mediterraneans. We interpret this myth as the Saharan people climate displacement which carried out cultural elements (lineal writings, usko-mediterranean languages) to Europe, mainly coming through Crete and Iberia, both of them having many prehistoric bounds with North Africans in language, genetics and cultural manifestations.
HLA and disease studies by using single allele statistics have been fruitless during the last 40 ... more HLA and disease studies by using single allele statistics have been fruitless during the last 40 years for explaining association pathogenesis of the associated diseases.Other approaches are necessary to untangle this puzzle. We aim to revisit complement alleleism in humans and primates for both studying MHC and disease association to complotypes and extended MHC haplotypes in order to also explain the positive directional selection of maintaining immune response genes (complement, MHC adaptive and MHC non-specific genes) that keeps these three type of genes together in a short chromosome stretch (MHC) for million years. These genes may be linked to conjointly avoid microbes attack and autoimmunity. In the present paper, it is obtained a new Bf chimpanzee allele, provisionaly named Patr-Bf*A:01,that differs from other Bf alleles by having CTG at eleventh codon of exon 2 in order to start the newly suggested methodology and explain functional and evolutionary MHC obscure aspects. Exo...
The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards M... more The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A, -B, -DRB1 and -DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported wi...
Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was ... more Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was constructed on a oasis in ancient times.However,it was a central point on the Silk Road and merchants from both Asia and Mediterranean/European areas crossed through Yazd City.We have studied HLA-A,-B,-DRB1 and DQB1 alleles in Yazd population.Analysys of nine most frequent extended class I and class II haplotypes shows that four of them are specific of this population.The other six haplotypes are also found in Asian and Mediterranean populations in significant frequency. This supports that the nowadays relatively isolated in desert Yazd area also contains people that may bear HLA genes probably originated because of long lasting merchants route between Europe and Asia through the European/Asian Silk Road in addition to other HLA genes close to other Iranian populations, including Kurds.
ClassicalHLA(Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA g... more ClassicalHLA(Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA genes and disease association has been studied at least since 1967 and no firm pathogenic mechanisms have been established yet.HLA-Gimmune modulation gene (and also-Eand-F) are starting the same arduous way: statistics and allele association are the trending subjects with the same few results obtained byHLAclassical genes, i.e., no pathogenesis may be discovered after many years of a great amount of researchers’ effort. Thus, we believe that it is necessary to follow different research methodologies: (1) to approach this problem, based on how evolution has worked maintaining together a cluster of immune-related genes (the MHC) in a relatively short chromosome area since amniotes to human at least, i.e., immune regulatory genes (MHC-G, -E and -F), adaptive immune classical class I and II genes, non-adaptive immune genes like (C2, C4 and Bf) (2); in addition to using new in vitro models whi...
The contribution of migrated people from once green Sahara (about 10,000-6000 years bc) towards M... more The contribution of migrated people from once green Sahara (about 10,000-6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A,-B,-DRB1 and-DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported with the results obtained in this Sudanese HLA study. However, demic diffusion model of agriculture and other anthropological traits from Middle East to West Europe/ Maghreb do not exist: a more detailed Sahel and North African countries ancient and recent admixture studies are also being carried out which may clearer explain pastoralists/agriculture innovations origins in Eurafrican Mediterranean and Atlantic façade.
HLA and disease studies by using single allele statistics have been fruitless during the last 40 ... more HLA and disease studies by using single allele statistics have been fruitless during the last 40 years for explaining association pathogenesis of the associated diseases.Other approaches are necessary to untangle this puzzle. We aim to revisit complement alleleism in humans and primates for both studying MHC and disease association to complotypes and extended MHC haplotypes in order to also explain the positive directional selection of maintaining immune response genes (complement, MHC adaptive and MHC non-specific genes) that keeps these three type of genes together in a short chromosome stretch (MHC) for million years. These genes may be linked to conjointly avoid microbes attack and autoimmunity. In the present paper, it is obtained a new Bf chimpanzee allele, provisionaly named Patr-Bf*A:01,that differs from other Bf alleles by having CTG at eleventh codon of exon 2 in order to start the newly suggested methodology and explain functional and evolutionary MHC obscure aspects. Exons 1 to 6 of Ba fragment of Bf gene were obtained from chimpanzee. This new chimpanzee Factor B allele (Patr-Bf*A:01) is to be identical to a infrequent human Bf allele (SNP rs641153); it stresses the strong evolutive pressure upon certain alleles that are trans specific. It also may apply to MHC extended haplotipes which may conjointly act to start an adequate immune response. It is the first time that a complement MHC class III allele is described to undergo trans species evolution,in contrast to class I and class II alleles which had already been reported. Allelism of complement factors are again proposed for studying MHC complement genes, complotypes, and extended MHC haplotypes which may be more informative that single MHC marker studies.
Lineal Megalithic Rock Scripts have been found by us: 1) associated to megaliths in Southern Iber... more Lineal Megalithic Rock Scripts have been found by us: 1) associated to megaliths in Southern Iberia Dolmens at Alcalar Dolmen (Portimao, Portugal), Cumbres Mayores Dolmens (Huelva, Spain) and in a fallen menhir at Zalamea la Real (Huelva, Spain); 2) not associated to megaliths in rocks or stones sizing from a fist in size to 110 cm or more at Zalamea la Real (Huelva, Spain) and other Malaga coastal sites; 3) in widespread rocks and stones in all main Canary Islands; and 4) in an Algerian Sahara shelter (Ti-m Missaou, Ahaggar Mountains area). These lineal megalithic rock scripts are sometimes identical to those of Iberian-Tartessian signary or are admixed with them on rocks. Other authors have also found them in several parts of southern Europe and also in Canary Islands. Some of the signs are repeated and have for us a funeral and religious meaning on the basis of Mother Goddess neolithic/paleolithic religion and Basque Iberian correspondence. It is postulated that these script...
Tartessos culture is placed in a wide area in southern Portugal and Spain after archeological and... more Tartessos culture is placed in a wide area in southern Portugal and Spain after archeological and documental studies. Its placement is concordant with that of West Euromediterranean ancient Megaliths, which were constructed at the Bronze Age (5000 year BC or before at Alcalar Dolmen (Portimao, Portugal), where Palelolithic arrows are found. These Megaliths construction and the people that built them up may be related to the metal richness of the core Tartessian Area: The Iberian Pyrite Belt which is rich in gold, silver, copper, iron, and others within this territory. Prehistoric documents place this area around Huelva, Cadiz (Spain) and South Portugal. Age of Tartessos may be older than established (centuries BC): Strabo said that Tartessians wrote 6000 years before. Indeed, we have found Megalithic Linear Scripts in a Megalith context (or not) in Tartessian area, Canary Islands and South Algerian Sahara, Mt Ahaggar area. These may represent a Megalithic Age writing which gav...
Nahua population (also named Aztecs or Mexicas) were studied for HLA class II genes in a Mexican ... more Nahua population (also named Aztecs or Mexicas) were studied for HLA class II genes in a Mexican rural city (Santo Domingo Ocotitlan, Morelos State) belonging to the nowadays Náhuatl speaking areas in Mexico. The most frequent HLA class II alleles were typical Amerindian (HLA-DRB1*04:07, DQB1*03:01 DRB1*04:03 or DRB1*04:04) and also were some calculated extended haplotypes (HLA-DRB1*04:07-DQB1*03:02,DRB1*08:02-DQB1*04:02, or DRB1*10:01-DQB1*05:01 among others). When using HLA-DRB1 Neís genetic distances, our isolated Nahua population was found to be close to other Central America Amerindians like the ancientestablished Mayans or Mixe. This may suggest that Nahuas origin was also from Central America. In contrast to legend that says they came from the North, and they built the Aztec Empire after submitting neighbouring ethnic groups before 1521 CE when Spaniards led by Hernán Cortés arrived to Mexico.
HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first t... more HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first time in Amerindians (Cuenca city area, Ecuador). It was found that most common extended haplotypes gathered the most frequent HLA-DRB1 Amerindian alleles. HLA-DMB polymorphism studies may be important to uncover HLA and diseases pathogenesis and also in an extended HLA haplotype frameshift. HLA-DM molecule has a crucial role together with CLIP protein in HLA class II peptide presentation. HLA extended haplotypes including complement and non classical genes alleles are proposed to HLA and disease studies.
HLA studies in Crete show that this population is related to North Africans and also Iberians. Th... more HLA studies in Crete show that this population is related to North Africans and also Iberians. This may be a reflection of a common prehistoric first Europeans relationships with North Africans and drying Saharan emigration after 10,000 years BC; it may be specifically represented by a primitive and early cult to the bull in both Cretan (Minoan) and Iberian populations. In the present study, unrelated Cretans representing different Island parts have been studied for class II HLA-DRB1 and-DQB1 alleles. The most frequent ones were HLA-DRB1*11:01 and HLA-DRB1*07:01 and HLA-DQB1*03:01 and DQB1*05:01. Also, the Cretan HLA class II haplotype HLA-DBR1*11:01-DQB1*03:01 had the highest frequency and is also common to other Mediterraneans, including Iberians. In addition, DRB1*07:01-DQB1*02:01 and HLA-DRB1*04:02-DQB1*03:02 Cretan haplotypes are shared with North Africans (the latter with Algerians, Tunisians and Moroccans). In summary, Crete was one of the first European classic cultures (Minoan) which was probably an early link, like Iberia, between North Africa /Sahara and Europe,also supported by genetic results.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
The myth of The Abduction or Rape of Europa tells that a Middle East aristocrat (princess) was ab... more The myth of The Abduction or Rape of Europa tells that a Middle East aristocrat (princess) was abducted by Zeus (gods father in Greek mythology) disguised as a white bull. The Bull-Zeus took Europa to Crete (Zeus birth place) and Europa became as the the first Creta Queen. Minos was one of the Zeus and Europa sons. He was a legendary Cretan King who kept the Minotaur a monster man with a bull head in a labyrinth. Some authors maintain that the Minotaur was a direct son of Europa and the Bull-Zeus. Crete was imposing Athens to offer young people that were left in the labyrinth and eaten by the Minotaur. Finally, Theseus, founder of Athens and Attica killed the Minotaur and freed Athens from being submitted. On the other hand, Cretan Lineal B was later discovered as Greek language; Cretan Lineal A (Minoan) is possible a Lineal B and Greek language precursor. Also, laws from Crete were taken to continental Sparta by Lycurgus. Crete genetics and bull culture are closer to Iberians than to other Europeans. This Europa myth was very popular all along classical Mediterraneans. We interpret this myth as the Saharan people climate displacement which carried out cultural elements (lineal writings, usko-mediterranean languages) to Europe, mainly coming through Crete and Iberia, both of them having many prehistoric bounds with North Africans in language, genetics and cultural manifestations.
HLA and disease studies by using single allele statistics have been fruitless during the last 40 ... more HLA and disease studies by using single allele statistics have been fruitless during the last 40 years for explaining association pathogenesis of the associated diseases.Other approaches are necessary to untangle this puzzle. We aim to revisit complement alleleism in humans and primates for both studying MHC and disease association to complotypes and extended MHC haplotypes in order to also explain the positive directional selection of maintaining immune response genes (complement, MHC adaptive and MHC non-specific genes) that keeps these three type of genes together in a short chromosome stretch (MHC) for million years. These genes may be linked to conjointly avoid microbes attack and autoimmunity. In the present paper, it is obtained a new Bf chimpanzee allele, provisionaly named Patr-Bf*A:01,that differs from other Bf alleles by having CTG at eleventh codon of exon 2 in order to start the newly suggested methodology and explain functional and evolutionary MHC obscure aspects. Exo...
The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards M... more The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A, -B, -DRB1 and -DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported wi...
Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was ... more Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was constructed on a oasis in ancient times.However,it was a central point on the Silk Road and merchants from both Asia and Mediterranean/European areas crossed through Yazd City.We have studied HLA-A,-B,-DRB1 and DQB1 alleles in Yazd population.Analysys of nine most frequent extended class I and class II haplotypes shows that four of them are specific of this population.The other six haplotypes are also found in Asian and Mediterranean populations in significant frequency. This supports that the nowadays relatively isolated in desert Yazd area also contains people that may bear HLA genes probably originated because of long lasting merchants route between Europe and Asia through the European/Asian Silk Road in addition to other HLA genes close to other Iranian populations, including Kurds.
ClassicalHLA(Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA g... more ClassicalHLA(Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA genes and disease association has been studied at least since 1967 and no firm pathogenic mechanisms have been established yet.HLA-Gimmune modulation gene (and also-Eand-F) are starting the same arduous way: statistics and allele association are the trending subjects with the same few results obtained byHLAclassical genes, i.e., no pathogenesis may be discovered after many years of a great amount of researchers’ effort. Thus, we believe that it is necessary to follow different research methodologies: (1) to approach this problem, based on how evolution has worked maintaining together a cluster of immune-related genes (the MHC) in a relatively short chromosome area since amniotes to human at least, i.e., immune regulatory genes (MHC-G, -E and -F), adaptive immune classical class I and II genes, non-adaptive immune genes like (C2, C4 and Bf) (2); in addition to using new in vitro models whi...
The contribution of migrated people from once green Sahara (about 10,000-6000 years bc) towards M... more The contribution of migrated people from once green Sahara (about 10,000-6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A,-B,-DRB1 and-DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported with the results obtained in this Sudanese HLA study. However, demic diffusion model of agriculture and other anthropological traits from Middle East to West Europe/ Maghreb do not exist: a more detailed Sahel and North African countries ancient and recent admixture studies are also being carried out which may clearer explain pastoralists/agriculture innovations origins in Eurafrican Mediterranean and Atlantic façade.
HLA and disease studies by using single allele statistics have been fruitless during the last 40 ... more HLA and disease studies by using single allele statistics have been fruitless during the last 40 years for explaining association pathogenesis of the associated diseases.Other approaches are necessary to untangle this puzzle. We aim to revisit complement alleleism in humans and primates for both studying MHC and disease association to complotypes and extended MHC haplotypes in order to also explain the positive directional selection of maintaining immune response genes (complement, MHC adaptive and MHC non-specific genes) that keeps these three type of genes together in a short chromosome stretch (MHC) for million years. These genes may be linked to conjointly avoid microbes attack and autoimmunity. In the present paper, it is obtained a new Bf chimpanzee allele, provisionaly named Patr-Bf*A:01,that differs from other Bf alleles by having CTG at eleventh codon of exon 2 in order to start the newly suggested methodology and explain functional and evolutionary MHC obscure aspects. Exons 1 to 6 of Ba fragment of Bf gene were obtained from chimpanzee. This new chimpanzee Factor B allele (Patr-Bf*A:01) is to be identical to a infrequent human Bf allele (SNP rs641153); it stresses the strong evolutive pressure upon certain alleles that are trans specific. It also may apply to MHC extended haplotipes which may conjointly act to start an adequate immune response. It is the first time that a complement MHC class III allele is described to undergo trans species evolution,in contrast to class I and class II alleles which had already been reported. Allelism of complement factors are again proposed for studying MHC complement genes, complotypes, and extended MHC haplotypes which may be more informative that single MHC marker studies.
Lineal Megalithic Rock Scripts have been found by us: 1) associated to megaliths in Southern Iber... more Lineal Megalithic Rock Scripts have been found by us: 1) associated to megaliths in Southern Iberia Dolmens at Alcalar Dolmen (Portimao, Portugal), Cumbres Mayores Dolmens (Huelva, Spain) and in a fallen menhir at Zalamea la Real (Huelva, Spain); 2) not associated to megaliths in rocks or stones sizing from a fist in size to 110 cm or more at Zalamea la Real (Huelva, Spain) and other Malaga coastal sites; 3) in widespread rocks and stones in all main Canary Islands; and 4) in an Algerian Sahara shelter (Ti-m Missaou, Ahaggar Mountains area). These lineal megalithic rock scripts are sometimes identical to those of Iberian-Tartessian signary or are admixed with them on rocks. Other authors have also found them in several parts of southern Europe and also in Canary Islands. Some of the signs are repeated and have for us a funeral and religious meaning on the basis of Mother Goddess neolithic/paleolithic religion and Basque Iberian correspondence. It is postulated that these script...
Tartessos culture is placed in a wide area in southern Portugal and Spain after archeological and... more Tartessos culture is placed in a wide area in southern Portugal and Spain after archeological and documental studies. Its placement is concordant with that of West Euromediterranean ancient Megaliths, which were constructed at the Bronze Age (5000 year BC or before at Alcalar Dolmen (Portimao, Portugal), where Palelolithic arrows are found. These Megaliths construction and the people that built them up may be related to the metal richness of the core Tartessian Area: The Iberian Pyrite Belt which is rich in gold, silver, copper, iron, and others within this territory. Prehistoric documents place this area around Huelva, Cadiz (Spain) and South Portugal. Age of Tartessos may be older than established (centuries BC): Strabo said that Tartessians wrote 6000 years before. Indeed, we have found Megalithic Linear Scripts in a Megalith context (or not) in Tartessian area, Canary Islands and South Algerian Sahara, Mt Ahaggar area. These may represent a Megalithic Age writing which gav...
Nahua population (also named Aztecs or Mexicas) were studied for HLA class II genes in a Mexican ... more Nahua population (also named Aztecs or Mexicas) were studied for HLA class II genes in a Mexican rural city (Santo Domingo Ocotitlan, Morelos State) belonging to the nowadays Náhuatl speaking areas in Mexico. The most frequent HLA class II alleles were typical Amerindian (HLA-DRB1*04:07, DQB1*03:01 DRB1*04:03 or DRB1*04:04) and also were some calculated extended haplotypes (HLA-DRB1*04:07-DQB1*03:02,DRB1*08:02-DQB1*04:02, or DRB1*10:01-DQB1*05:01 among others). When using HLA-DRB1 Neís genetic distances, our isolated Nahua population was found to be close to other Central America Amerindians like the ancientestablished Mayans or Mixe. This may suggest that Nahuas origin was also from Central America. In contrast to legend that says they came from the North, and they built the Aztec Empire after submitting neighbouring ethnic groups before 1521 CE when Spaniards led by Hernán Cortés arrived to Mexico.
HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first t... more HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first time in Amerindians (Cuenca city area, Ecuador). It was found that most common extended haplotypes gathered the most frequent HLA-DRB1 Amerindian alleles. HLA-DMB polymorphism studies may be important to uncover HLA and diseases pathogenesis and also in an extended HLA haplotype frameshift. HLA-DM molecule has a crucial role together with CLIP protein in HLA class II peptide presentation. HLA extended haplotypes including complement and non classical genes alleles are proposed to HLA and disease studies.
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