Davide Rondina
Universidade Estadual do Ceara, Faculdade De Veterinária Da, Faculty Member
... The preantral follicular population was classified in three types or categories: pri-mordial follicles, primary follicles and secondary follicles. ... From ovaries ten fragments were submitted to preantral follicles isolation using a... more
... The preantral follicular population was classified in three types or categories: pri-mordial follicles, primary follicles and secondary follicles. ... From ovaries ten fragments were submitted to preantral follicles isolation using a mechanical method adapted from Figueiredo et al. ...
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Diet can influence both the qualitative and quantitative traits of ruminant meat. This study evaluated the effects of castor de-oiled cake on the meat of mixed-breed male goat kids. After 165days of diet treatment, no alterations... more
Diet can influence both the qualitative and quantitative traits of ruminant meat. This study evaluated the effects of castor de-oiled cake on the meat of mixed-breed male goat kids. After 165days of diet treatment, no alterations (p>0.05) were observed in the in vivo performance, anatomic components, dissection and proximate composition of the Longissimus dorsi muscle, as well as in the color and pH of the carcasses. However, diet had an effect (p<0.05) on energy metabolites, fatty acid profile, and expression of certain proteins of the Longissimus dorsi muscle. To conclude, this study showed that the establishment of castor de-oiled cake diet for a long period to goats led to alterations in meat quality, without compromising its consumption qualities.
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A expressão de RNAm para leptina, receptor de leptina (obRb), adiponectina, receptor de adiponectina (AdipoR1) e resistina foi avaliada por meio da técnica de PCR em tempo real, em tecidos ovariano, hipofisário, adiposo do omento e da... more
A expressão de RNAm para leptina, receptor de leptina (obRb), adiponectina, receptor de adiponectina (AdipoR1) e resistina foi avaliada por meio da técnica de PCR em tempo real, em tecidos ovariano, hipofisário, adiposo do omento e da região perirrenal, em ovelhas alimentadas sem farelo de mamona ou com farelo de mamona detoxificada durante 14 meses. O tipo de dieta não afetou os níveis de RNAm para leptina, obRb, adiponectina, AdipoR1 e resistina nos diferentes tecidos avaliados (P>0,05). Nos tecidos ovariano e hipofisário, não foi verificada a expressão da adiponecina e da resistina, respectivamente. Como consequência, pode-se concluir que o farelo de mamona detoxificada pode ser utilizado como fonte proteica na dieta de ovelhas, sem afetar a expressão do gene resistina e dos genes leptina e adiponectina, bem como de seus receptores.
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The uterus plays an important roles in the female reproduction, such as hormone production and maintenance of pregnancy, and it is known that these functional attributes are influenced by nutrition. Thus, the aim of this study was to... more
The uterus plays an important roles in the female reproduction, such as hormone production and maintenance of pregnancy, and it is known that these functional attributes are influenced by nutrition. Thus, the aim of this study was to assess the effect of different levels of energy intake on the protein profile of goat uteri. All procedures used in this study were approved by the Ethics Committee in Animal Experimentation of the Ceara State University (no 12066667-7/18). Anglo-Nubian cross-bred (n=24), non-lactating, pluriparous and cycling adult does were selected from a farm herd and grouped according to feed levels (n=6 per group; 4 groups). Such groups were homogeneously distributed based on (P > 0.05) live weight, (30.0 ± 2.7 kg), body condition score (2.8 ± 0.2), sternal subcutaneous fat thickness (9.15 ± 1.1 mm) and age (28.9 ± 5.6 months),. Experimental groups received a diet composed of Bermudagrass hay and concentrate (67% TDN and 10% CP), supplied during four weeks to satisfy 1.0 (Group A), 1.3 (Group B), 1.6 (Group C), and 1.9 (Group D) times the nutritional requirement for maintenance of adult nondairy goats (NRC, 2007). At slaughter, uterine tissue samples were collected, stored in sterile tubes and frozen at - 80o C until protein extraction. Tissue fragments were frozen-dried and macerated. Protein extraction was performed in cold PBS containing 0.1% triton X-100. Samples were centrifuged for 30 min at 5000 rpm and the supernatant eliminated. Proteins were then re-suspended in ultrapure water and protein concentration was determined according to the Bradford’s method. Uterine proteins (400 μg) were subjected to 2D-SDS PAGE. The samples were analyzed individually for each treatment. All gels were stained with Comassie G250 (BioRad Laboratories, USA) and analyzed by the PDQuest™ 8.0.1 software (BioRad Laboratories, USA). Spots of interest were excised from gels, trypsin-digested and subjected to tandem mass spectrometry. Data were analyzed by ANOVA or the KruskallWallis test. On average, 101 proteins were detected in the gels, regardless the treatment groups. However, the average intensity of the spots were lower for group D (7761817,5 pxs) in comparison with group A (9146241,0 pxs), B (9680350,7 pxs) and C (9869550,7 pxs). Major proteins present were between 12.0 kDa and 128.6 kDa molecular weight. A total of 8 differential spots were identified, between groups, with molecular weights between 14.0 kDa/4.8 PI and 73.6 kDa/6.9 PI. No differential spot was present in a unique group. Therefore, for a better understanding of the results, the next step of this work is the identification of the differential protein spots.
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Background and Aim: Despite the wide spectrum of uses, one of the chief drawbacks to expanding microalgae as a food supplement in livestock is the lack of a regimen protocol with established dosage and time length of supplementation.... more
Background and Aim: Despite the wide spectrum of uses, one of the chief drawbacks to expanding microalgae as a food supplement in livestock is the lack of a regimen protocol with established dosage and time length of supplementation. Therefore, this study aimed to investigate the effect of short-term supplementation with increasing doses of microalgae on ovarian response in goats reared in northeast Brazil. Materials and Methods: Twenty-eight goats had their follicular waves synchronized using three injections of a prostaglandin analog at 7-day intervals. Goats were allocated to groups that received daily oral Chlorella supplementation for 7 days, respectively: 5 g, GMA5 group (n = 7), 10 g (GMA10; n = 7), and 20 g (GMA20; n = 7). The control group (GMA 0; n = 7) received a drench of water. Results: The groups showed a quadratic increase (p = 0.0156) in kidney fat thickness but there was a significant reduction in dry matter intake in the GMA20 group. The GMA20 group showed higher g...
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Here, we aimed to discriminate between the spectral profiles of spent culture media after oocyte in vitro maturation (IVM) and culture (IVC) from goats of different ages subjected to repeated hormonal treatments. The profiles were... more
Here, we aimed to discriminate between the spectral profiles of spent culture media after oocyte in vitro maturation (IVM) and culture (IVC) from goats of different ages subjected to repeated hormonal treatments. The profiles were discriminated using near infrared (NIR) spectroscopy combined with multivariate methods. A total of 19 goats (young = 10; old = 9) were subjected to serial hormonal stimulation (HS) with gonadotropins. Cumulus oophorus complexes (COCs) were collected using laparoscopic ovum pick-up (LOPU) and subjected to IVM and parthenogenetic activation. The initial embryos were subjected to IVC. Spent culture media were collected after oocyte IVM and on day 2 of IVC and analyzed using NIR spectroscopy. NIR spectral data were interpreted through chemometric methods, such as principle component analysis (PCA) and partial least square discriminant analysis (PLS-DA). The results of PCA analysis clearly showed a separation in the spectral profiles between the experimental g...
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ABSTRACT: This study evaluated the performance at slaughtering of calves; young bull and bull of Maremmana breed, and compared, through Analysis of Variance (ANOVA) and Principal Component Analysis (PCA) on fatty acid composition, the... more
ABSTRACT: This study evaluated the performance at slaughtering of calves; young bull and bull of Maremmana breed, and compared, through Analysis of Variance (ANOVA) and Principal Component Analysis (PCA) on fatty acid composition, the characteristics of the resulting meat categories: veal, young bull meat and bull meat. The Maremmana cattle is a local endangered breed deriving from Tuscany and Latium. The animals of this study were raised under same conditions in pasture with hay and concentrate supplementations. Eighteen calves of 12-14 months, 27 young bulls of 18 months and 14 bulls of 20-24 months were slaughtered in this trial. The performances at slaughtering were considered, and on the meat samples, the chemical analysis and the fatty acid composition were carried out. Results were submitted to ANOVA and PCA, and a Heat map that considered the fatty acid distances among meat typologies was built. Slaughtering performances were better in young bulls and bulls. Chemical composi...
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Background: A better comprehension of the relationship between nutrition and ovarian function is a fundamental key to optimize the reproductive parameters. In ruminants it is well known and recognized that nutrition is a very important... more
Background: A better comprehension of the relationship between nutrition and ovarian function is a fundamental key to optimize the reproductive parameters. In ruminants it is well known and recognized that nutrition is a very important mediator at the ovary level. Thus, nutritional balancing is a critical essential condition in assisted reproduction technologies when used to support improves reproductive efficiency. In many regions of Brazil, the main drawback of ovine and caprine husbandry continues to be how to sustain the nutritional status during the prolonged seasonal food shortage. In these areas the use of hormonal treatment for both estrus and ovulation synchronization is subordinate to supplementation availability or the body condition of females. Changes of nutrient intake before mating can significantly increase in the superovulatory response and modify the number and quality of embryo produced in vivo. The objective of this paper is to review the effects of nutrition on ...
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Background: A better comprehension of the relationship between nutrition and ovarian function is a fundamental key to optimize the reproductive parameters. In ruminants it is well known and recognized that nutrition is a very important... more
Background: A better comprehension of the relationship between nutrition and ovarian function is a fundamental key to optimize the reproductive parameters. In ruminants it is well known and recognized that nutrition is a very important mediator at the ovary level. Thus, nutritional balancing is a critical essential condition in assisted reproduction technologies when used to support improves reproductive efficiency. In many regions of Brazil, the main drawback of ovine and caprine husbandry continues to be how to sustain the nutritional status during the prolonged seasonal food shortage. In these areas the use of hormonal treatment for both estrus and ovulation synchronization is subordinate to supplementation availability or the body condition of females. Changes of nutrient intake before mating can significantly increase in the superovulatory response and modify the number and quality of embryo produced in vivo. The objective of this paper is to review the effects of nutrition on ...
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Avaliou-se o efeito da adição de bagaço de caju desidratado (BCD), durante o pós-parto, em 41 ovelhas, alojadas com suas crias em baias, onde recebiam, à vontade, 75% de capim-elefante + 25% de concentrado (DI; n=17), ou 50% de BCD + 25%... more
Avaliou-se o efeito da adição de bagaço de caju desidratado (BCD), durante o pós-parto, em 41 ovelhas, alojadas com suas crias em baias, onde recebiam, à vontade, 75% de capim-elefante + 25% de concentrado (DI; n=17), ou 50% de BCD + 25% de capim-elefante + 25% de concentrado (DII; n=24). Cinquenta dias pós-parto, o estro foi sincronizado, e as ovelhas submetidas à monta natural. O grupo DI perdeu mais peso (P<0,05), e o consumo de proteína bruta e de fibra em detergente neutro foi maior nesse grupo (P<0,001). A inclusão de BCD na dieta II induziu ao aumento do consumo de matéria seca, extrato etéreo e fibra em detergente ácido (P<0,001) e redução significativa das concentrações de colesterol, lipídios totais, albumina e proteína total (P<0,001). Não houve diferença entre os grupos (P>0,05) no tempo de retorno do primeiro corpo lúteo funcional, na resposta à sincronização do estro e nas taxas de gestação e prolificidade. A inclusão de 50% de BCD amenizou as perdas de ...
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This study was conducted to assess the effect of lipid supplementation on the proteomic profile of milk fat globule membrane (MFGM) and mammary gland tissue (MGT) in lactating goats. Thirty-eight crossbred goats received a total mixed... more
This study was conducted to assess the effect of lipid supplementation on the proteomic profile of milk fat globule membrane (MFGM) and mammary gland tissue (MGT) in lactating goats. Thirty-eight crossbred goats received a total mixed ration (TMR) based on chopped elephant grass and concentrate during 35 days post-partum. They were divided into three diet groups two weeks after kidding, namely, Control group (CG; n = 12), fed baseline TMR; Flaxseed group (FG; n = 13), fed ground flaxseed added to the TMR for 21 days (12% total dry matter); and microalgae Chlorella group (MCG; n = 13), fed microalgae Chlorella added to the TMR for 21 days (0.05% live weight). Blood plasma concentrations of total protein, albumin, and glutathione peroxidase were determined. Weekly milk samples were used to estimate milk yield and protein and fat levels. MGT samples were biopsied on the 35th day of the experiment. The protein profile of MFGM and MGT was assessed using 1D SDS–PAGE and mass spectrometry....
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Lipotoxicity is characterized by excessive saturated fatty acids in the blood, increasing storage in non-adipose cells, which leads to changes in the expression pattern of genes related to endoplasmic reticulum stress (e.g., ATF4, ATF6,... more
Lipotoxicity is characterized by excessive saturated fatty acids in the blood, increasing storage in non-adipose cells, which leads to changes in the expression pattern of genes related to endoplasmic reticulum stress (e.g., ATF4, ATF6, CHOP, and GRP78), pro- and anti-apoptotic pathways (e.g., Bax and Bcl-2, and protein stability, including heat shock proteins, e.g., HSP70). A negative sub-cellular effect is usually an end result, which also occurs in the ovarian follicular population, affecting granulosa cells and cumulus-oocyte complexes (COCs), which leads to a decrease in oocyte quality and mitochondrial activity, and increased apoptosis. The addition of high doses of non-esterified fatty acids to oocyte in vitro maturation medium has been shown to slow the progression of meiosis, hampering oocyte maturation and subsequent in vitro embryo development. Due to its importance in the control of cellular lipid droplets and expression correlation with cytosolic lipid accumulation, the...
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The availability of glycerol has increased because of the biofuels industry, and glycerol can have a significant effect on reproductive efficiency when used as an alternative energy source in animal feeds. The aim of this study was to... more
The availability of glycerol has increased because of the biofuels industry, and glycerol can have a significant effect on reproductive efficiency when used as an alternative energy source in animal feeds. The aim of this study was to investigate the effects of pre-mating oral drenching of glycerin on ovarian and fertility responses in goats. Sixty Anglonubian mixed-breed goats were submitted to estrus synchronization by CIDR-prostaglandin PGF2α treatment and mated. At CIDR removal, onset of estrus, and 24 h after estrus behavior, the animals received 150 ml of saline solution (control group, n = 20), 150 ml of glycerol (150 ml group, n = 20), or 300 ml of glycerol (300 ml group, n = 20). The administration of glycerin increased plasma glucose in the 300 ml group (P < 0.05) and the insulin concentration at 12 h after glycerin drenching in both treated groups. Goats from the 300 ml group showed a lower ovulation rate when compared to the control group (1.15 ± 0.08 ...
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O objetivo deste trabalho foi desenvolver um modelo preditivo através de técnica multivariada para diferenciar meios de cultivo de células-tronco cultivadas in vitro e criopreservadas de acordo com os perfis de absorbância obtidas por... more
O objetivo deste trabalho foi desenvolver um modelo preditivo através de técnica multivariada para diferenciar meios de cultivo de células-tronco cultivadas in vitro e criopreservadas de acordo com os perfis de absorbância obtidas por NIR. Para tanto, foram coletados meios de cultivo de células-tronco oriundo do fluido amniótico de fetos caprinos, antes e após o processo de criopreservação por vitrificarão, e submetidos à análise pelo NIR. Foi possível estimar com alta acurácia o tratamento empregado nas amostras, gerando uma impressão digital dos meios de cultivo in vitro de células criopreservadas ou não. Palavras-chave: Cultivo in vitro, espectros, modelo preditivo.
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Background: Lipotoxicity is characterized by an excess of saturated fatty acids in the blood stream, in which other nonadipose cells begin to store them, thereby altering the expression of genes related to endoplasmic reticulum stress,... more
Background: Lipotoxicity is characterized by an excess of saturated fatty acids in the blood stream, in which other nonadipose cells begin to store them, thereby altering the expression of genes related to endoplasmic reticulum stress, whose effects have been associated with decreased oocyte quality in several species, decreased mitochondrial activity, and increased apoptosis. The present study was conducted to investigate the lipotoxicity effect of diets with increasing fat levels on gene expression in goat’s oocyte and granulosa cells. Materials, Methods & Results: Thirty does were divided into three groups of 10 animals each, which received forage and concentrate to provide respectively 2.7% of lipids (LL group), 3.9% lipids (LI group) and 5.1% lipids (LH group) for 28 days. Three days before oocyte harvest, follicular wave was synchronized by 1 mL PGF2α intramuscularly, followed by the insertion of an intravaginal progesterone release device. Viable oocytes and granulosa cells w...
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Background : Recent evidence shows that the renin-angiotensin system (RAS) participates in important reproductive processes, such as steroidogenesis, folliculogenesis, oocyte maturation and ovulation. Several studies have proposed to use... more
Background : Recent evidence shows that the renin-angiotensin system (RAS) participates in important reproductive processes, such as steroidogenesis, folliculogenesis, oocyte maturation and ovulation. Several studies have proposed to use an angiotensin-converting enzyme (ACE) as a RAS modulator, aiming to improve reproductive efficiency, however, the presence of the main components of this system in reproductive tissues still need to be further investigated, since the physiological functions seem to be species-specific. The aim of this study was to assess the impact of enalapril-maleate, an ACE inhibitor, during repeated gonadotropins treatment on ovarian blood flow and follicular development in goats. Materials, Methods and Results : Twenty Anglo-Nubian cross-bred goats were equally grouped according to parity (n=10/group): nulliparous and multiparous parity. In each group, five animals were randomly selected to receive 0.4 mg.kg -1 of enalapril-maleate during 11 days of estrus syn...
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This trial was carried out with the objective to evaluate the effect of feeding dried carnauba wax palm fruit on the quality of goat meat. Initially, the animals were divided into two groups: a control group, fed with ground corn-based... more
This trial was carried out with the objective to evaluate the effect of feeding dried carnauba wax palm fruit on the quality of goat meat. Initially, the animals were divided into two groups: a control group, fed with ground corn-based concentrate, and a treatment group, fed with dried carnauba wax palm fruit included in the concentrate. After 28 days of feeding, the animals were slaughtered, and different muscles (Longissimus lumborum and semimembranosus) were evaluated for physicochemical characteristics, fatty acid profile, and expression of some genes related to meat quality. The diet with carnauba wax palm fruit does not interfere in the chemical composition of the meat in terms of moisture content, protein, fat, pH, and meat color. On the other hand, palmitic (C16:0) and linoleic (C18:2) fatty acids presented differences between muscles in the group fed carnauba wax palm fruit. The treatment with carnauba wax palm fruit reduces the expression of genes related to lipogenesis an...
RESUMO O objetivo do trabalho foi avaliar o efeito do escore da condição corporal (ECC) materno sobre a capacidade de isolamento, expansão e caracterização de células-tronco mesenquimais (CTMs) derivadas do cordão umbilical de fetos... more
RESUMO O objetivo do trabalho foi avaliar o efeito do escore da condição corporal (ECC) materno sobre a capacidade de isolamento, expansão e caracterização de células-tronco mesenquimais (CTMs) derivadas do cordão umbilical de fetos caprinos. Para tanto, dezenove cabras mestiças adultas, pluríparas foram agrupadas de acordo com o ECC, atribuindo-se um escore de 1-5, (GB) grupo baixo com menor ECC, (2,3±0,1, GB, n = 9) e (GA) grupo alto com maior ECC (2,9±0,1, GA, n = 10). Durante o parto, fragmentos do cordão umbilical foram coletados e cultivados in vitro e avaliados a taxa de proliferação celular. Nenhum efeito significativo do ECC foi encontrado para os parâmetros considerados. Palavras-chave: Células-tronco mesenquimais, escore da condição corporal, caprino.
Abstract The goal of this study was to assess the effect of using native food sources (cashew apple bagasse ( Anacardium occidentale ), cassava root scrapings ( Manihot esculenta ), and wax palm fruit ( Copernicia prunifera )) as corn... more
Abstract The goal of this study was to assess the effect of using native food sources (cashew apple bagasse ( Anacardium occidentale ), cassava root scrapings ( Manihot esculenta ), and wax palm fruit ( Copernicia prunifera )) as corn replacement in the balanced feed of goats as oocyte donors for cloning procedures. After four weeks of feeding, we evaluated follicular development and fluid composition, in vivo maturation rate and oocyte competence assessed by in vitro embryo production by cloning, and the expression pattern of GDF9, BMP15, BAX, and BCL2 gene products in oocytes. Type of feed had no effect on the live weight and sternal subcutaneous fat thickness in goats, measured prior to oocyte harvesting. Inclusion of wax palm fruit in the foodstuff significantly increased the number of aspirated follicles, number of recovered oocytes, and glucose concentrations in the follicular fluid. However, maturation rates and in vitro embryo yield were not affected by the type of foodstuff. Our results also showed that the test diets induced underexpression of GDF9 and did not affect oocyte developmental capacity or the efficiency of the cloning process under our experimental conditions. In general, inclusion of alternative foodstuff in the diet of adult oocyte donor goats as replacement for corn was effective in maintaining oocyte developmental capacity, being as successful in supporting in vitro embryo production by cloning procedures in goats. The alternative food ingredients used for a period of four weeks can effectively replace corn in the diet without appearing to compromise animal health and fertility, which is an economic and viable alternative for goat production in tropical regions, contributing to the current trend in global sustainability.
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ABSTRACT This study aimed to assess the effects of dietary supplementation with crude glycerin on embryo quality and expression profile of genes from superovulated goats. Twenty-four hours (1 day) and 72 hours (3 days) after mating... more
ABSTRACT This study aimed to assess the effects of dietary supplementation with crude glycerin on embryo quality and expression profile of genes from superovulated goats. Twenty-four hours (1 day) and 72 hours (3 days) after mating animals received an oral drench of 200 mL saline solution (Control group), 100 mL glycerol (100 mL group) or 200 mL glycerol (200 mL group). Both insulin and glucose levels were measured after glycerol drenching. The relative expression of genes (Glut-1, IGF-1, Hsp70, Sod and Bax) in grade I and II embryos from groups was analyzed by sensitive TaqMan qPCR. Administration of crude glycerin raised insulin and glucose (p &lt; 0.05) plasma concentrations. Similar rates of superovulatory response (94.12%; 16/17) and recovery of transferable embryos (N embryo grades 1, 2 and 3/N ovulation), (44.69 ± 6.83%; 100/224) were obtained. The 200 mL group showed a greater proportion of transferable embryos compared to the degenerated embryos (8.83 ± 2.30 vs. 1.17 ± 0.83, p &lt; 0.05), that achieved values 2-fold higher than control group (4.80 ± 2.30 vs. 0.20 ± 0.20, p &lt; 0.05) and 100 mL group (3.83 ± 1.25 vs. 1.17 ± 0.48, p &gt; 0.05). A higher relative abundance of IGF-1 transcripts was observed in 200 mL group. Also none differences were observed for transcripts of apoptotic (Bax) and stress (Hsp70) genes. In conclusion, enhancement of circulating glucose and insulin generated from drenching crude glycerin after mating was associated with higher IGF-I expression and increased proportion of transferable embryos.
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The use of alternative protein sources that do not impair animal performance is a feasible option to reduce costs associated with animal supplementation. Previous studies indicate that castor cake has a high protein value and good ruminal... more
The use of alternative protein sources that do not impair animal performance is a feasible option to reduce costs associated with animal supplementation. Previous studies indicate that castor cake has a high protein value and good ruminal degradability, making it an attractive alternative dietary source for ruminants. Thus, the aim of this study was to evaluate the effects from ingestion of castor cake (treatment CC) or detoxified castor cake (treatment DCC) on serum IgG levels, in vivo production of goat embryos, and the expression profile of genes related to embryonic development, metabolism, and oxidative stress. The results showed the presence of IgG against ricin only in animals of the CC group. The ovulation rate and the production of transferable embryos in animals of the CC group were lower (P < 0.05) than in the animals fed without castor cake (WCC), but neither group differed significantly from the DCC group. There was no effect of type of diet on the expression of the ...
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... gradualmente com o avançar da idade, como nos ovinos, enquanto que em outros animais, pode persistir durante a vida adulta (roedores, hibernantes, homem) (CANNON & NEDERGAARD, 2004). ... linfonodos e na musculatura esquelética... more
... gradualmente com o avançar da idade, como nos ovinos, enquanto que em outros animais, pode persistir durante a vida adulta (roedores, hibernantes, homem) (CANNON & NEDERGAARD, 2004). ... linfonodos e na musculatura esquelética (VERNON & HOUSEKNECHT, 2000 ...
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This study evaluated the effect of detoxified castor meal on the reproductive performance, metabolic stress, milk production, and kid development in peripartum goats. The diet of the animals were with (DCM, n= 20) or without (WDCM, n= 21)... more
This study evaluated the effect of detoxified castor meal on the reproductive performance, metabolic stress, milk production, and kid development in peripartum goats. The diet of the animals were with (DCM, n= 20) or without (WDCM, n= 21) detoxified castor meal during the entire gestation and until weaning, 60 days post-birth. No differences were observed in the gestation period, litter size, rate of multiple births, and mortality between the two groups. The postpartum plasma concentrations of progesterone remained below 1ng/mL in all animals, thus, confirming the absence of active corpora lutea. The thickness of sternum adipose tissue and loin area, levels of urea and cholesterol, milk production, and daily weight gain in the kids were low in the DCM group when compared to those in the WDCM group (P< 0.05). To conclude, the use of detoxified castor meal in peripartum goats resulted in lower level of performance in the kids because of reductions in the amount of milk received fro...