Adolescence is a period of experimenting, when bravery, responsiveness to peers’ influence, psychological and emotional instability, and the tendency towards consumption of illegal substances are common conducts. Similar to smoking and... more
Adolescence is a period of experimenting, when bravery, responsiveness to peers’ influence, psychological and emotional instability, and the tendency towards consumption of illegal substances are common conducts. Similar to smoking and drinking, the consumption of substances erroneously known as ethnobotanics has become increasingly popular among teenagers. The aim of this study is to document the circumstances of the use of these substances, as well as the clinical consequences they bear on the patients. In 2015, there were 95 patients admitted to the Toxicology Department of ”Saint Mary” Emergency Children’s Hospital Iași, due to ethnobotanics. 76.84% of these were male. Most of the consumers (53.7%) were between 16 and 18 years old, although a significant proportion (41%) were even younger (13-15 years old). They often took ethnobotanic drugs in gatherings (86%), many of them having previously contact with these substances (32%). Social and familial factors must be taken into account, for exemple: growing up in an orphanage (35%), school dropout (17%), conflicts within the family (27%). The main symptoms encountered at the arrival at the Emergency Department were: euphoria (27%), disturbance of balance (17%), tachycardia, syncope, drowsiness, headache, dyspeptic disorders. All cases evolved favourably under supportive treatment. The study illustrates the widespread use of such substances among youths, requiring social, psychological and educational measures in order to raise awareness of the risks of consumption and to combat this phenomenon.
Research Interests:
Research Interests:
Research Interests:
Toxic coma is a complication of acute poisoning and the most common cause of non-traumatic coma in children. We performed a retrospective study on a group of 154 children, aged 0-18 years old, admitted with toxic coma during 1.01.2011 and... more
Toxic coma is a complication of acute poisoning and the most common cause of non-traumatic coma in children. We performed a retrospective study on a group of 154 children, aged 0-18 years old, admitted with toxic coma during 1.01.2011 and 31.12.2017. The study group included only the patients who received a Glasgow score < 8 at the initial evaluation. We excluded from the study all children with poisonings and other disorders of consciousness such as drowsiness or stupor (Glasgow score: 14-9). The study analyzed: the toxic products involved depending on age, sex, origin, and also the evolution after treatment administration. We noticed that toxic coma was prevalent in children over 12 years old (59%). Coma due to non-drugs poisonings was more frequent (68.8%) than drug-induced coma (31.2%). Only 20.7% of patients required orotracheal intubation. The evolution was favorable in most cases; only 3 deaths were registered (1.9%). Toxic etiology should be evoked in any coma of unknown cause that occurs suddenly in a previously healthy child.
Research Interests:
<jats:p>Toxic coma is a complication of acute poisoning and the most common cause of non-traumatic coma in children. We performed a retrospective study on a group of 154 children, aged 0-18 years old, admitted with toxic coma during... more
<jats:p>Toxic coma is a complication of acute poisoning and the most common cause of non-traumatic coma in children. We performed a retrospective study on a group of 154 children, aged 0-18 years old, admitted with toxic coma during 1.01.2011 and 31.12.2017. The study group included only the patients who received a Glasgow score &lt; 8 at the initial evaluation. We excluded from the study all children with poisonings and other disorders of consciousness such as drowsiness or stupor (Glasgow score: 14-9). The study analyzed: the toxic products involved depending on age, sex, origin, and also the evolution after treatment administration. We noticed that toxic coma was prevalent in children over 12 years old (59%). Coma due to non-drugs poisonings was more frequent (68.8%) than drug-induced coma (31.2%). Only 20.7% of patients required orotracheal intubation. The evolution was favorable in most cases; only 3 deaths were registered (1.9%). Toxic etiology should be evoked in any coma of unknown cause that occurs suddenly in a previously healthy child.</jats:p>
Research Interests:
Research Interests: Medicine and Thoracotomy
Dyspnea in infants and small children is a common symptom of addressability to a medical service. For a doctor, setting a diagnosis is challenging, because dyspnea can be a symptom in multiple conditions. The first step in establishing... more
Dyspnea in infants and small children is a common symptom of addressability to a medical service. For a doctor, setting a diagnosis is challenging, because dyspnea can be a symptom in multiple conditions. The first step in establishing the diagnosis of dyspnea in children is explaining the mechanism (obstructive dyspnea, nonobstructive or “sine materia”). In the presence of an obstructive dyspnea, besides common causes (laryngitis, bronchiolitis, bronchial asthma, aspiration of foreign bodies), some mediastinal disorders should be evoked. We present the case of a one year and two month old male patient, presented for cough, expiratory dyspnea and wheezing, the presumed clinical diagnosis being acute bronchitis. Given that dyspnea was enhanced under treatment, a chest radiograph was performed, which revealed a homogeneous oval opacity occupying almost the entire right thorax. Thoracic CT revealed in the right lateromediastinal part a tumor with an apparently cystic form, with inner calcifications, with left displacement of the mediastinal structures. Thoracotomy with tumor excretion was performed, macroscopically seemed to be teratoma, microscopically confirmed. The child has undergone subsequent chemotherapy treatment with favorable evolution.
Research Interests: Medicine and Thoracotomy
Despite the progress in vaccinology, antibiotic therapy and intensive care, the sepsis and septic shock in children remain a major cause of morbidity and mortality worldwide, mainly in countries with low medical resources. Therefore,... more
Despite the progress in vaccinology, antibiotic therapy and intensive care, the sepsis and septic shock in children remain a major cause of morbidity and mortality worldwide, mainly in countries with low medical resources. Therefore, efforts have been made for implementation of worldwide protocols considering the management of septic shock in infants. The definitions of sepsis, septic shock and multiple organ dysfunction syndrome (MODS) are similar with the conditions present in adults, the difference consisting in the values of heart rate, respiratory frequency and leukocytes. The management of septic shock in children was detailed in “Surviving Sepsis Campaign” (SSCG) since 2005 and subsequent periodically reviewed. However, most of these recommendations were based on the general agreement of specialists without serious evidence or just based on studies conducted on adults. Therefore, in recent years we witness a change in the management of septic shock at pediatric age, from stan...
Research Interests:
Sepsis has recently been redefined as a potentially lethal organ dysfunction caused by a dysregulated host organism’s response to infection. Due to the high mortality rate and hospitalization costs, early diagnosis is necessary, as... more
Sepsis has recently been redefined as a potentially lethal organ dysfunction caused by a dysregulated host organism’s response to infection. Due to the high mortality rate and hospitalization costs, early diagnosis is necessary, as it allows more aggressive treatment to be applied in the first 6 hours following detection. There are a lot of clinical and biological parameters used as biomarkers to asses the severity of sepsis and the mortality risk. Nevertheless, there is no “standard” biomarker, nor a combination of biomarkers with predictive value, which enable the early detection of sepsis, prior to the onset of clinical signs. Moreover, markers such as the number of leukocytes and neutrophils, C-reactive protein or procalcitonin have been shown to have low specificity, especially when used individually. The authors review the literature data regarding the main categories of sepsis biomarkers: proinflammatory citokines, acute-phase proinflammatory mediators, cell-su...
Research Interests:
Research Interests:
Research Interests:
Despite the progress in vaccinology, antibiotic therapy and intensive care, the sepsis and septic shock in children remain a major cause of morbidity and mortality worldwide, mainly in countries with low medical resources. Therefore,... more
Despite the progress in vaccinology, antibiotic therapy and intensive care, the sepsis and septic shock in children remain a major cause of morbidity and mortality worldwide, mainly in countries with low medical resources. Therefore, efforts have been made for implementation of worldwide protocols considering the management of septic shock in infants. The definitions of sepsis, septic shock and multiple organ dysfunction syndrome (MODS) are similar with the conditions present in adults, the difference consisting in the values of heart rate, respiratory frequency and leukocytes. The management of septic shock in children was detailed in “Surviving Sepsis Campaign” (SSCG) since 2005 and subsequent periodically reviewed. However, most of these recommendations were based on the general agreement of specialists without serious evidence or just based on studies conducted on adults. Therefore, in recent years we witness a change in the management of septic shock at pediatric age, from stan...
Research Interests:
Research Interests:
Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human... more
Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human health in pediatrics. For this purpose, the demographic characteristics, clinical assessment, and outcome of pediatric patients with acute pesticide poisoning admitted to the toxicology department of “Saint Mary” Emergency Children’s Hospital from Iasi, were analyzed. This retrospective study focused on the clinical and laboratory data of patients aged under 18 years diagnosed with acute pesticide poisoning between 2010–2020. The statistical analysis was performed using the Statistica 10 package. A total of 49 patients presented with manifestations of acute pesticide poisoning, and the most common pesticide involved was diazinon. The most frequent exposure route was accidentally ingesting pesticide products (95%). The primary clinical manifestations w...
Research Interests:
Accidentul vascular cerebral (AVC) este rar la copil comparativ cu adultul. Cauzele cele mai comune de AVC la copil sunt cardiopatiile emboligene pentru infarctul cerebral şi malformaţiile arteriovenoase pentru hemoragiile cerebrale, dar... more
Accidentul vascular cerebral (AVC) este rar la copil comparativ cu adultul. Cauzele cele mai comune de AVC la copil sunt cardiopatiile emboligene pentru infarctul cerebral şi malformaţiile arteriovenoase pentru hemoragiile cerebrale, dar un număr de cazuri rămân idiopatice, fără a li se putea afi rma etiologia precisă. Autorii prezintă cazul unui copil diagnosticat în perioada de sugar cu malformaţie congenitală de cord cianogenă complexă, dar neoperată, internat cu semne clinice şi radiologice de pneumonie, care a evoluat favorabil sub tratament antibiotic şi simptomatic. În timpul perioadei rezolutive a pneumoniei, copilul devine brusc somnolent, prezentând hemiplegie dreaptă cu absenţa reflexelor de aceeaşi parte. Examenul clinic corelat cu CT cranio-cerebral au stabilit diagnosticul de AVC ischemic sylvian bilateral. Evoluţia a fost favorabilă sub tratament conservator (antiagregante plachetare, fizioterapie), persistând însă hemiplegia dreaptă.
Research Interests:
Dentocalminul este un anestezic de contact, analgezic şi antiseptic utilizat pentru tratament local în stomatologie. Intoxicaţia cu această substanţă determină manifestări clinice grave datorate lidocainei şi fenolului, principalii... more
Dentocalminul este un anestezic de contact, analgezic şi antiseptic utilizat pentru tratament local în stomatologie. Intoxicaţia cu această substanţă determină manifestări clinice grave datorate lidocainei şi fenolului, principalii constituenţi activi. Prezentăm cazul unui sugar de 11 luni intoxicat accidental cu dentocalmin, internat cu stare de rău convulsiv urmat de stop cardiorespirator. A fost resuscitat şi ventilat mecanic timp de 24 ore. Evoluţia a fost favorabilă, în pofi da dozei toxice mari şi a complicaţiilor survenite ca urmare a intubării orotraheale – pneumotorax, pneumomediastin şi emfi zem subcutanat cervical şi toracic, copilul fi ind externat după 10 zile, cu stare generală bună, fără sechele neuropsihice.
Research Interests:
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care... more
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care pacientul poate necesita îngrijiri în terapie intensivă. Scopul acestui studiu constă în evaluarea retrospectivă, într-o perioadă de 3 ani, a frecvenţei unor comorbidităţi care au determinat transferul bolnavilor din secţia de hemato-oncologie în cea de terapie intensivă. Lotul de studiu a cuprins 54 de copii (vârsta 9 luni-17 ani) reprezentând 1,2% din totalul inernărilor în hemato-oncologie în intervalul menţionat. Dintre hemopatiile maligne admise în terapie intensivă a predominat LAL (31% din cazuri). Insufi cienţa respiratorie a constituit principalul motiv de transfer (23 de cazuri – 42,5%), urmat de sepsis şi şoc (17 cazuri – 31,4%). Principalele tratamente specifi ce efectuate în terapie intensivă au fost oxigenoterapia (21 de cazuri), reechilib...
Boala Gaucher este cea mai frecventă maladie lizozomală, cu transmitere autosomal recesivă. Boala se datorează deficitului enzimei glucocerebrozidază, rezultând în acumularea de glucocerebrozide în toate organele. Diagnosticul se... more
Boala Gaucher este cea mai frecventă maladie lizozomală, cu transmitere autosomal recesivă. Boala se datorează deficitului enzimei glucocerebrozidază, rezultând în acumularea de glucocerebrozide în toate organele. Diagnosticul se stabileşte prin măsurarea activităţii enzimei. Dintre formele clinice, tipul 2 este cel mai rar şi are prognosticul cel mai sumbru. Prezentăm cazul unui sugar depistat la vârsta de 5 luni cu simptome neurologice şi evoluţia lui ulterioară cu hepatosplenomegalie masivă, fiind diagnosticat cu tipul 2 de boală Gaucher.
Otitis media (OM) represents a public health matter, being the main cause of preventable hearing loss in pediatric patients. Besides well-established risk factors for developing OM, such as craniofacial abnormalities, prematurity, low... more
Otitis media (OM) represents a public health matter, being the main cause of preventable hearing loss in pediatric patients. Besides well-established risk factors for developing OM, such as craniofacial abnormalities, prematurity, low birth weight, or tobacco exposure, there is evidence that obesity could be associated with a high incidence of OM. Our aim is to perform a literature review on the state of current published research on the relationship between OM and obesity and to discuss the interconnectivity between these two entities. We conducted an electronic search in PubMed and EMBASE databases. Out of 176 references, 15 articles were included in our study. Our findings suggest that obesity and overweight might be risk factors for developing OM, and vice versa. The main mechanisms for developing OM in obese patients include alteration in cytokine profile, increased gastroesophageal reflux, and/or fat accumulation. Conversely, ear infections exposure might increase the risk of ...
Research Interests:
Research Interests:
Research Interests:
Ascaris lumbricoides este un nematod al cărui ciclu de viaţă include migrarea larvelor prin peretele intestinal în circulaţia sanguină; prin vena portă ajung în cord, mica circulaţie, plămân, căi respiratorii, de unde sunt eliminate prin... more
Ascaris lumbricoides este un nematod al cărui ciclu de viaţă include migrarea larvelor prin peretele intestinal în circulaţia sanguină; prin vena portă ajung în cord, mica circulaţie, plămân, căi respiratorii, de unde sunt eliminate prin tuse şi reînghiţite. Citrobacter este un gen de bacili gram negativi anaerobi coliformi, din familia Enterobacteriaceae, care se găseşte în: sol, apă, apă menajeră şi intestinul uman. Autorii prezintă cazul unui copil în vârstă de patru ani şi şapte luni diagnosticat cu supuraţie pleuro-pulmonară cu Citrobacter şi endocardită infecţioasă, favorizate de infestarea masivă cu ascarizi. Sunt trecute în revistă principalele caracteristici ale genului Citrobacter precum şi aspectele mai importante ale infestării cu ascarizi.
Etilenglicolul este unul dintre cei mai toxici alcooli, fiind consumat accidental sau voluntar, ca substituent al etanolului sau în scop suicid. Ingestia de etilenglicol determină, prin metaboliţii săi toxici, acidoză metabolică severă,... more
Etilenglicolul este unul dintre cei mai toxici alcooli, fiind consumat accidental sau voluntar, ca substituent al etanolului sau în scop suicid. Ingestia de etilenglicol determină, prin metaboliţii săi toxici, acidoză metabolică severă, cu creşterea hiatusului anionic şi osmotic, conducând la un tablou clinic ce asociază deprimarea sistemului nervos central, afectare cardiovasculară şi insuficienţă renală. Prezentăm cazul unui pacient în vârstă de 16 ani internat pentru semne clinice şi biologice de intoxicaţie cu etilenglicol apărute după ingestia simultană de antigel şi alcool. Pacientul a prezentat acidoză metabolică doar la debut, rapid corectată de o doză de bicarbonat de sodiu; investigaţiile ulterioare nu au relevat acidoză, chiar dacă în evoluţie a apărut insuficienţa renală acută ce a necesitat hemodializă. Datorită absenţei anamnezei pozitive şi a acidozei metabolice persistente, diagnosticul de intoxicaţie cu etilenglicol a fost întârziat până la confirmarea prin testul t...
Ventricular preexcitation syndromes (VPS) are very important between cardiac rhythm disturbances in childhood, because their presence can change the clinical and ECG picture and thus the treatment can be very difficult. The authors... more
Ventricular preexcitation syndromes (VPS) are very important between cardiac rhythm disturbances in childhood, because their presence can change the clinical and ECG picture and thus the treatment can be very difficult. The authors studied 58 cases of VPS in children (2 weeks-15 years old) admitted in a period of 3 years. The surface ECG showed VPS aspects: in 30% of cases we noticed WPW syndrome type B and the rest presented VPS with Mahaim pathways and Lown-Ganong-Levine syndrome. 4 cases were familial and 1 child a hidden WPW syndrome. In 65% of cases the cardiac symptoms put the diagnosis and 1/3 of cases were discovered by common ECG. The most important cardiac sign of the children with WPW syndrome was the paroxysmal supraventricular tachycardia, 4 cases presenting wide QRS complex. Others types of VPS were without clinical symptoms. The intravenous administration of digoxin + propranolol was the therapy of choice for paroxysmal supraventricular tachycardia in infants and chil...
Research Interests:
The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with an actual or potential tissue injury that is described as such, emphasizing the subjective nature.... more
The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with an actual or potential tissue injury that is described as such, emphasizing the subjective nature. The cognitive-behavioural therapy has begun to be applied for psychosomatic problems in dental problems. There are several types of techniques: relaxation, biofeedback, exposure and cognitive restructuring. In general, therapists may combine several of the above techniques to treat patients with dental anxiety.
Sudden Infant Death Syndrome (SIDS) represents the third cause in postnatal mortality. The pathogenesis is multifactorial. SIDS victims can present sign of preexisting chronic asphyxia, persistent increase in dendritic spine and delayed... more
Sudden Infant Death Syndrome (SIDS) represents the third cause in postnatal mortality. The pathogenesis is multifactorial. SIDS victims can present sign of preexisting chronic asphyxia, persistent increase in dendritic spine and delayed maturation of synapses in medullary respiratory centers, if a decreased reactivity of 5 hydroxytryptamine 1A (5-HT1A) and 5-HT2A in the dorsal nucleus of the vagus, solitary nucleus and ventrolateral medulla. SIDS is an exclusion diagnosis, so that inexplicable SIDS is the accepted term. The objective of this report is to present current data about the pathogenesis oh this syndrome and the medico-legal measures applied in preventive and curative aim. The “face-up” sleeping position has cut in half the SIDS frequency. In conclusion, the infant sleep studies represent an important line for the future research to provide sufficient explanation of the sudden death in these infants.
Research Interests:
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study... more
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy.72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix-Ochoa score), which also underwent the upper digestive endoscopy.Out of the 72 children diagnosed with GERD, 47 (65.28%) had grade A esophagitis and 25 (34.72%) grade B esophagitis. In GERD associated with grade B esophagitis the Boix-Ochoa score is statistically significant higher, compared with the GERD associated with grade A esophagitis (F = 9.76, P = .0036, 95% CI).Upper digestive endoscopy performed in patients with g...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Amitriptyline (Antideprin) determines severe intoxications, especially because of its cardiac side effects. We studied 8 children (2-14 years old) admitted with signs of amitriptyline intoxication. The clinical picture revealed altered... more
Amitriptyline (Antideprin) determines severe intoxications, especially because of its cardiac side effects. We studied 8 children (2-14 years old) admitted with signs of amitriptyline intoxication. The clinical picture revealed altered general status, generalized hypertonia, arterial hypotension up to collapse, mydriasis, coma and cardiac arrhythmia. ECG monitoring showed ventricular premature beats, isolated, couplets and triplets, ventricular tachycardia and torsade des points, severe ventricular repolarisation disturbances with diffuse subendocardial ischemia. The treatment consisted in: gastric lavage with activated charcoal, alkalinisation with sodium bicarbonate, antiarrhythmic drugs and sustained vital functions. All cases recovered in 4-6 days. The severity of amitriptyline intoxication requires continue clinical and ECG monitoring, for early detection of some life threatening cardiovascular events. Thus, the treatment will be started early and will alleviate the severe prog...
Research Interests:
An 11 year-old boy was admitted with incessant sinus node reentrant tachycardia and secondary dilated arrhythmic cardiomyopathy, treated by radiofrequency ablation. Two years later he was admitted with incessant automatic atrial... more
An 11 year-old boy was admitted with incessant sinus node reentrant tachycardia and secondary dilated arrhythmic cardiomyopathy, treated by radiofrequency ablation. Two years later he was admitted with incessant automatic atrial tachycardia and arrhythmic cardiomyopathy; a second catheter ablation procedure failed, but the third one, performed four month later, was successfully and resulted in a restoration of a normal sinus rhythm and a complete regression of arrhythmic cardiomyopathy.
Research Interests:
Actual researches show that adenosine and its forerunner, ATP, can realise a nodal block in intravenous (i.v.) administration. This effect, even if transient, is of particular usefulness in the therapy of paroxysmal supraventricular... more
Actual researches show that adenosine and its forerunner, ATP, can realise a nodal block in intravenous (i.v.) administration. This effect, even if transient, is of particular usefulness in the therapy of paroxysmal supraventricular tachycardia (PST) in children and adults. 1 mg/kg ATP was administered i.v. to 51 children (aged 3 months to 15 years) admitted to the Intensive Care Unit for severe regular paroxysmal tachyarrhythmias with clinical and ECG symptoms. In 31 cases, the P wave was absent on ECG. In 6 of 31 cases in whom wide QRS complexes were found (over 0.10 sec), a WPW syndrome (4 cases) or bundle branch block (2 cases) was associated. Rapidly i.v. administration monitored electrocardioscopically was followed by ending of PST in 43 children, including those with wide QRS complexes. The highest effectiveness was in junctional tachycardia by re-entering mechanism. The drug was well tolerated, had no side effects or hemodynamic disturbances and this is very important, becau...
Research Interests:
Research Interests:
Ethylene glycol is one of the most toxic alcohols; it may be accidentally or intentionally consumed as a substitute for ethanol or related to suicidal attempts. Ingestion of ethylene glycol causes a severe metabolic acidosis with... more
Ethylene glycol is one of the most toxic alcohols; it may be accidentally or intentionally consumed as a substitute for ethanol or related to suicidal attempts. Ingestion of ethylene glycol causes a severe metabolic acidosis with increased anion and osmotic gap due to its toxic metabolites, leading to a clinical picture of central nervous system depression, cardiovascular and renal impairment. A 16-year-old boy was admitted with clinical and biological signs of ethylene glycol poisoning after simultaneous ingestion of antifreeze and ethanol. The patient had mild anion gap metabolic acidosis only at the debut, rapidly corrected with one dose of sodium bicarbonate; further evaluation did not reveal acidosis, even if the subsequent evolution included acute renal failure requiring hemodialysis. Due to the absence of a positive history and of a persistent metabolic acidosis, the diagnosis of ethylene glycol poisoning was delayed until it was confi rmed by serum toxicological test. Conclu...
Mitral valve prolapse (MVP) is fairly common in children, often being randomly found in asymptomatic, as well as in symptomatic patients with conjunctive tissue diseases (CTD). The authors report the case of an 11-yearold girl, diagnosed... more
Mitral valve prolapse (MVP) is fairly common in children, often being randomly found in asymptomatic, as well as in symptomatic patients with conjunctive tissue diseases (CTD). The authors report the case of an 11-yearold girl, diagnosed at the age of 6 with MVP and severe mitral regurgitation (MR). She had surgery at the age of seven, when the mitral valve replacement with a biological valve prosthesis was performed. Four years later, the girl was admitted for sudden onset of dyspnoea with orthopnoea, haemoptysis and generalized cyanosis. The diagnosis of acute pulmonary oedema and degenerated biological valvular prosthesis correlated with severe mitral stenosis was evoked by means of clinical and echocardiographic examinations. The evolution was favourable after the replacement of the bioprosthesis with a mechanical prosthesis.
Research Interests:
Gaucher disease is the most common lysosomal storage disorder, with autosomal recessive transmission. The disease is due to glucocerebrosidase enzyme defi ciency, resulting in accumulation of glucocerebroside in all organs. The diagnosis... more
Gaucher disease is the most common lysosomal storage disorder, with autosomal recessive transmission. The disease is due to glucocerebrosidase enzyme defi ciency, resulting in accumulation of glucocerebroside in all organs. The diagnosis is established by measuring enzyme activity. Among the clinical forms, type 2 is the rarest and has the most dismal prognosis. We present the case of an infant found at 5 months of age with neurological symptoms and his subsequent evolution with massive hepatosplenomegaly, being diagnosed with type 2 Gaucher disease.
ACUTE GASTROENTERITIS IN CHILDREN. CURRENT EPIDEMIOLOGICAL AND ETIOLOGICAL CONSIDERATIONS (Abstract): Acute diarrheal disease ranks second among the causes of specific morbidity (after respiratory infections) with higher incidence values... more
ACUTE GASTROENTERITIS IN CHILDREN. CURRENT EPIDEMIOLOGICAL AND ETIOLOGICAL CONSIDERATIONS (Abstract): Acute diarrheal disease ranks second among the causes of specific morbidity (after respiratory infections) with higher incidence values in economically undeveloped or developing countries (3 to 7 episodes of diarrhea / year / child compared to only 1-2 episodes / year / child in highly industrialized countries). Infection with Campylobacter globally was the most frequently reported zooanthroponosis, with 214,268 confirmed human cases in 2012. Almost any pathogen involved in the etiology of acute diarrheal disease may be involved in the occurrence of healthcare-associated infections; among these, the rotavirus and Clostridium difficile are most prevalent. General hygiene measures change the epidemiological aspect of acute diarrheal disease by modifying the factors which favor the transmission of pathogens.
Stroke is rare in children compared to adults. Most common causes of stroke in children are heart diseases that cause embolism and cerebral infarction and arteriovenous malformations for the brain hemorrhages, but a number of cases remain... more
Stroke is rare in children compared to adults. Most common causes of stroke in children are heart diseases that cause embolism and cerebral infarction and arteriovenous malformations for the brain hemorrhages, but a number of cases remain idiopathic, without being able to say precise etiology. The authors present the case of a child diagnosed in infancy with complex cyanotic heart malformation, but not operated, admitted with clinical and radiological signs of pneumonia, which evolved favorably with antibiotic and symptomatic therapy. During resolution of the pneumonia, the child becomes suddenly drowsy, presenting right hemiplegia, with absence of refl exes on the same side. Clinical examination correlated with cranio-cerebral CT have established the diagnosis of bilateral Sylvian ischemic stroke. The evolution was favorable under conservative treatment (antiplatelet drugs, physiotherapy), but right hemiplegia persisted.
Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We... more
Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and pustular lesions, initially located in the inguinal and perianal regions and on thighs, and very few erythematous lesions on the face. Due to the numerous bacterial skin superinfections with Staphylococcus aureus, including abscesses that required surgical incision, the clinical picture was modified, leading to a delayed establishment of the diagnosis. Later, the symptoms became suggestive for this disease, the diagnostic having been confirmed by low plasma zinc values. Under zinc therapy, skin lesions improved significantly in a few days, with favorable outcome. Two months later, the skin lesions almost disappeared. Abscesses due to bacterial skin superinfections may lead to initially misd...
Research Interests:
Research Interests:
The issue of maternity in adolescence is an important one due to the increasing number of adolescent mothers in our country, as well as in other countries, because of the risks involved by a pregnancy at this age, especially from a... more
The issue of maternity in adolescence is an important one due to the increasing number of adolescent mothers in our country, as well as in other countries, because of the risks involved by a pregnancy at this age, especially from a medical perspective, but also from a social one. Material and methods: The current study was conducted between 2012 and 2017 on a group of 103 adolescent mothers aged between 12 and 19 years of age, with a total of 109 children admitted to the Pediatric Recovery Department of Iasi “Sf. Maria” Emergency Hospital for Children. Results: The distribution of adolescent mothers by age was: 12%-12 years old, 10%-13 years old, 11% -14 years old, 12%-15 years old, 13%-16 years old, 14%-17 years old, 15%-18 years old, 15%-19 years old. Consideration was given to the existence of acute illnesses during the pregnancies for the mothers included in the study, the background, the level of education, the jobs and the marital status of the young parents, the birth weight ...
Collodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis. The authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged... more
Collodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis. The authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged hospitalization in the intensive care unit because of infectious complications like the fungal sepsis and other bacterial superinfections. The case has many diagnostic and therapeutic particularities and management difficulties. Skin culture, dermatological and genetic exam were required. The treatment required multidisciplinary involvement: neonatologist, pediatrician, geneticist, dermatologist, psychologist, ophthalmologist, audiologist. The evolution during hospitalization was slowly favorable, but later, after a few months, it developed some complications. In our case, skin injuries, total parenteral nutrition, aggressive and prolonged antibiotic therapy, intravenous devices, high hospitalization duration were risk factors for colonization and sepsis with f...