Vishal Pande

Roller compaction is a dry granulation process device procedure in which the powders containing active ingredients and excipients are agglomerated between the compactor rollers. The dry powders of the active ingredients and excipients are combined in a blender during roller compaction, and further rollers are compacted and milled to form granulesThe resulting granules are then blended within in a blender and used for compression into tablets or for capsule filling. Compaction of powder is the term used to describe the situation in which these materials are subjected to some level of mechanical force. In pharmaceutical industries, the effects of such forces are very important in manufacturing of granule and tableting Particulate matter is compressed and densified in a roller compactor by rotating the material between two high pressure rollers. From a roller compactor, the densified material is then reduced by Frying to a uniform granule size. Roll compaction / dry granulation is a me...

Granulation is the most important step in tablet formulation when dealing with substances which are sensitive to moisture. The essential move depends on the success of the formulation. The present study focuses on the use of adapted granulation technology (GT), involving the use of least moisture while creating stable granules; the moisture activated dry granulation technique (MADG). ).The technology overcomes problem of degradation of substances by water since it employs use of negligible amount of water (as moisture). The current article deals with in depth basic information about granule growth mechanisms during granulation and effectiveness over wet conventional wet granulation. Moisture Activated Dry Granulation (MADG) was created in response to the difficulties of endpoint, drying, and milling encountered with wet granulation. It also overcomes the problem of showing undesirable bimodal distribution in relation to having either too many fines or too many (or both) coarse parti...

In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and esti...

In case cancers are located deep inside the body and are very tough to diagnose, diagnostic tools like MRI/CT scans can be employed to detect these cancers. The major challenge in such cases is the delivery of MRI active agents or visualizing agents to the target site. In this context we will discuss different mesoporous nanoparticles that can be employed to target the tissue at a specific location, its functionalization to reach the target site (Folic acid), different simple dyes as well as specific dyes which offer theranostic functionality. The nanoparticles like mesoporous silica nanoparticles offer the possibility to load therapeutic and diagnostic agents. Its surface allow multiple functionalization and conjugations which offer target specific delivery of these agents. Moreover we will also overview different modern drug delivery inventions for offering theranostic application.

Amla wine is one of the most acidic alcoholic beverages prepared by using various fermentation conditions such as fermenting agent, temperature, duration, juice concentration variation or by addition of jaggery. In this present study, Amla wine was analyzed for titrable acidity, volatile acidity, free SO2 content, total soluble solids, pH, reducing sugar, alcohol content by GC, ascorbic acid content, total phenolic content, total flavonoids content, etc. The marker constituent in Amla wine was identified by TLC, HPTLC, IR and antioxidant activity was determined using DPPH free radical scavenging assay. The influence of the yeast (Saccharomyces cerevisiae) on self generated alcohol (SGA) content as ethanol was observed in range of 1.20-2.40%. Whereas by using flowers of Woodfordia fruticosa (L.) Kurz as the source of fermenting yeast, ethanol reached up to 1.0-1.70%. Feeding of excess jaggery in the formulation increases the ethanol content up to 8.69% and 9.29%. The trace amount of ...

JETIR2004367 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 1235 NANOSPONGE AS A NEW NANOENGINEERING HORIZON FOR DRUG DELIVERY: A REVIEW Rohit Gorde, Shubham Vadak,Ajinkya Kurhe, Vishal Pande* a Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra-423603, India. b Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra-423603, India. c Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra-423603, India. d Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra-423603, India. Abstract

Recently, extended release pharmaceutical products become a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because easy of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency.

The aim of this research work was to create compelling strategy for biosurfactant generation by waste potato peels and pulp utilizing mutated B.subtilis DDU20161. Major parameters like creation of medium, fomentation, and pH were kept up in the investigation. The ideal biosurfactant yield by acetone extraction technique was 253.79 mg L-1 with biomass of 3.56 gL-1 at 40 h. The produced biosurfactant was characterised by studying surface tension, emulsification index, TLC, CMC and FTIR. The highest emulsification index was 75.05% in benzene, Critical micelle concentration(CMC) was found to be 0.028μM, and FT-IR study revealed presence of peptide bond at 3188cm-1 (=N-H). The results of stability study indicated that the produced biosurfactant is stable at 300-1000C without any significant change in surface tension properties of biosurfactant. The shaped biosurfactant was found to be stable in alkaline pH. The present work was focussed on developing a production methods utilizing aceton...

The synthesis, characterization and quantitation of process related impurity in Nimodipine i.e.Diethyl 2, 6-dimethyl-4-(2-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate bulk and tablet formulation was performed by using Hantzch pyridine synthesis. This synthesis includes o-nitrobenzaldehyde, ethylacetoacetate in presence of ammonia and methanol as catalyst. The percentage yield was found to be 79%. The impurity was recrystallized and preliminary evaluation was done on lab scale viz. Melting point, TLC and elemental analysis. The melting point of impurity was found to be 156-158 0 C. The TLC of impurity was carried out by using benzene and methanol (6:1) and the Rf was found to be 0.78 the conformation of synthesized Nimodipine impurity was carried out by using sophisticated instrument such as, FT-IR, NMR, GC-MS, and RP-HPLC method was developed to identify and quantify the Nimodipine impurity in bulk and formulation as per ICH Q2B guidelines. The method was found to be linear,...

The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and ...

In the present study, we have formulated zaltoprofen loaded, surface decorated, biodegradable gelatin nanogel and evaluated its texture characterization. The method used to prepare gelatin nanoparticles (GNP) was 'two step desolvation' and its surface decoration was performed with oleic acid (OA). The GNP was optimized by DOE software. Nanogels were evaluated for particle size entrapment efficiency, texture properties, SEM, in-vitro, ex-vivo drug release studies, in-vitro characterization, stability and in vivo evaluation of nanogel for anti-inflammatory activity was carried out by carrageenan induced rat paw edema method as an anti-inflammatory experimental model. The formulated GNP with particle size and entrapment efficiency of optimized batch was found to be 247.1 nm and 76.21% respectively. The SEM of GNP shows smooth and spherical shape. In-vitro and Ex-vivo drug release shows that there was 69.47% and 78.59% drug released within 48 hrs. It follows Ritger peppas model, which indicates sustained drug release. The good texture properties of nanogel were observed from texture analysis graphs.In vivo studies of our formulation give significant results compared to the marketed nanogel. Stability data revealed stability of nanogel formulation up to 3 months. The present approach can provide us promising results of the sustained analgesic activity and the stability of drug within the GNP.

The present study reveals the use of Oral Thin Film (OTF) prepared by solvent casting technique. The prepared Montelukast loaded OTF can be used in emergency condition of severe asthmatic attacks. The comparison study by using Poly (ethylene) Oxide N-750 (PEO) and Hydroxy propyl methyl cellulose E15 (HPMCE15) as film forming polymer was performed. The results obtained for film disintegration and dissolution time tested orally correlated well with those obtained by the visual method. There was considerable reduction in film strength and increase in percent elongation of film with increase in glycerol content. The result showed that film containing PEO N-750 with 5 % glycerol showed better disintegration, dissolution and folding endurance when compared with film containing HPMCE15. Hence, the film containing PEO was used for further optimization where the optimized formulation (F2) depicted disintegration time of less than 6 sec, complete drug release within 8 min, percent elongation ...

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>

In the present study rapid melt tablets (RMT's) of carvedilol were prepared by using ionotropic-gelated chitosan nanoparticles using a spray-drying method. Carvedilol is beta-adrenergic antagonist and its oral bioavailability is about 25-35% because of first pass metabolism. The spray-dried microparticles were formulated into RMT's using a wet granulation process. The Formulation and optimization of carvedilol loaded RMTs using nano and microparticulate chitosan based system (NMCS) was done by using 32 factorial designs. Drug entrapment efficiency of about 64.9 % (w/w) and loading capacity of 14.44% (w/w) were achieved for the microparticles, which were ranged from 1 μm to 4 μm in diameter. RESULTS of disintegration tests showed that the formulated RMTs could be completely dissolved within 40 seconds. Dissolution studies suggested that Carvedilol is released more slowly from tablets made using the microencapsulation process compared with tablets containing Carvedilol that is free or in the form of nanoparticles. RESULTS shown that the development of new RMTs designed with crosslinked microparticle might be a rational way to overcome the unwanted taste of conventional RMTs and the side effects related to Carvedilol intrinsic characteristics. The development of Carvedilol NMCS using ludiflash as RMTs could be used as a promising approach for improving the solubility and oral bioavailability of water insoluble drug.

A simple, fast and reliable spectrophotometric method was developed for determination of deferasirox in bulk and pharmaceutical dosage forms. Beer’s law was obeyed in concentration range of 2–12 µ/ml deferasirox at 245.6 nm wavelength. The correlation coefficient was found to be (r2 = 0.999), precision (repeatability % RSD 1.29), percentage recovery 100.054±0.271. The detection limit (DL) and quantitation limit (QL) were 0.247µg/ml and 0.75 µg/ml respectively. The proposed method was found to be simple, accurate, precise, reproducible and gives an acceptable recovery of the analyte, which can be directly and easily applied to analysis of bulk and pharmaceutical tablet formulations of deferasirox. Keywords – Deferasirox, UV spectrophotometry, Area under curve

In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitrorelease study showed lag time of 5–8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

The objective of this work was to develop a bioadhesive topical gel of sertaconazole nitrate with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Carbapol 934 = X1) and Sodium carboxymethylcellulose (NaCMC) = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial design and generated quadratic mathematical equations. On the basis of product character...