Ricardo Tabach
Universidade de Santo Amaro (UNISA), Biologia, Faculty Member
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ABSTRACT
The effects of ethanol dependence on the sensitivity of the transmurally-stimulated mouse vas deferens to gamma-aminobutyric acid (GABA), noradrenaline and histamine were studied. Tissues isolated from ethanol-dependent mice showed... more
The effects of ethanol dependence on the sensitivity of the transmurally-stimulated mouse vas deferens to gamma-aminobutyric acid (GABA), noradrenaline and histamine were studied. Tissues isolated from ethanol-dependent mice showed supersensitivity to the twitch inhibitory effect GABA. Sensitivity to noradrenaline and histamine was not significantly altered. Exposure to ethanol in vitro significantly increased the sensitivity of the isolated mouse vas deferens to the inhibitory effect of histamine, noradrenaline and GABA. Pretreatment of vasa deferentia isolated from ethanol-dependent mice with bicuculline did not block the ethanol-induced supersensitivity to GABA, and naloxone was without effect on the supersensitivity to GABA observed in the transmurally-stimulated mouse vas deferens. It is concluded that ethanol dependence induces supersensitivity of the transmurally-stimulated mouse vas deferens to GABA, which is mediated by a bicuculline and naloxone-insensitive GABA receptor.
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... [ Links ]. Balmé F 1978. Plantas Medicinais. São Paulo: Hemus. [ Links ]. ... [ Links ]. Carai MAM, Agabio R, Bombardelli E, Bourov I, Gessa GL, Lobina C, Morazzoni P, Pani M, Reali R, Vacca G, Colombo G 2000. Potential use of... more
... [ Links ]. Balmé F 1978. Plantas Medicinais. São Paulo: Hemus. [ Links ]. ... [ Links ]. Carai MAM, Agabio R, Bombardelli E, Bourov I, Gessa GL, Lobina C, Morazzoni P, Pani M, Reali R, Vacca G, Colombo G 2000. Potential use of medicinal plants in the treatment of alcoholism. ...
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ABSTRACT This chapter contains sections titled: IntroductionPlants with CNS Depressant ActivityPlants with the CNS Stimulant ActivityPlants Used as AntidepressantsAdaptogenic PlantsPlants Used to Treat Neurodegenerative DiseasesPlants... more
ABSTRACT This chapter contains sections titled: IntroductionPlants with CNS Depressant ActivityPlants with the CNS Stimulant ActivityPlants Used as AntidepressantsAdaptogenic PlantsPlants Used to Treat Neurodegenerative DiseasesPlants with the Mind-Altering ActivityPlants Used Against Drug DependenceConclusions AcknowledgmentsReferences
... Elisaldo A. Carlini * ; Joaquim M. Duarte-Almeida; Eliana Rodrigues; Ricardo Tabach. Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Botucatu, 862, 04023-062 São Paulo-SP, Brasil. ... Brito AR, Rodriguez JA,... more
... Elisaldo A. Carlini * ; Joaquim M. Duarte-Almeida; Eliana Rodrigues; Ricardo Tabach. Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Botucatu, 862, 04023-062 São Paulo-SP, Brasil. ... Brito AR, Rodriguez JA, Hiruma-Lima CA, Haun M, Nunes DS. ...
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Research Interests: Biochemistry, Organic Chemistry, Natural Products Chemistry, Fertility, Ethnopharmacology, and 17 morePharmaceutical Chemistry, Biological Sciences, Phytotherapy, Dogs, Mice, Weight Loss, Female, Animals, Male, CHEMICAL SCIENCES, Plant extracts, Rats, Passiflora, Wistar Rats, Lethal Dose, Weight Gain, and Crataegus
Research Interests: Flavonoids, Saponins, Biological Sciences, Antioxidants, Phytotherapy, and 20 morePolyphenols, Mice, Animals, Corticosterone, Lignans, Alkaloids, CHEMICAL SCIENCES, Coumarins, Phenols, Plant extracts, Rats, Dilleniaceae, Blood Viscosity, Ulcer, Wistar Rats, Adrenocorticotropic Hormone, Tannins, Physiological Stress Markers, Maze Learning, and Baccharis
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