C. Lugnier
Université de Strasbourg, Pharmacologie, Emeritus
Research Interests:
... Handbook of ELISPOT: Methods and Protocols, edited by Alexander E. Kalyuzhny, 2005 301. ... 239 19. Analysis of Dimerization Determinants of the PDE6 Catalytic Subunits Khakim G. Muradov, Kimberly K. Boyd, and Nikolai O. Artemyev........ more
... Handbook of ELISPOT: Methods and Protocols, edited by Alexander E. Kalyuzhny, 2005 301. ... 239 19. Analysis of Dimerization Determinants of the PDE6 Catalytic Subunits Khakim G. Muradov, Kimberly K. Boyd, and Nikolai O. Artemyev..... ...
Research Interests:
The distribution of phosphodiesterase (PDE) activities was studied in canine cardiac microsomal fractions separated by sucrose density gradient (fractions F1 to Fv1). These fractions were characterized by their 45Ca2+ uptake and release... more
The distribution of phosphodiesterase (PDE) activities was studied in canine cardiac microsomal fractions separated by sucrose density gradient (fractions F1 to Fv1). These fractions were characterized by their 45Ca2+ uptake and release properties, [3H] ryanodine binding [used as sarcoplasmic reticulum (SR) markers] and their [3H]nitrendipine binding (as a T-system marker). The solubilized canine and human SR-enriched membranes were subjected to high performance liquid chromatography and the PDE forms were then analyzed for their kinetic properties and drug sensitivies. In human SR, a notable amount of PDE I hydrolyzing both cAMP and cGMP was characterized; however, its stimulation by calmodulin was reduced. Two selective cAMP-PDE forms were identified in the canine and human cardiac SR-enriched fractions. The major form presents the characteristics of PDE III: an apparent Km value of 0.29 and 0.35 microM in canine and human cardiac SR, respectively, potent inhibition by cGMP and AA...
Research Interests:
Research Interests: General, Female, Animals, Male, Vasoconstriction, and 5 morePhosphodiesterase Inhibitors, Rats, Rat, Wistar Rats, and cyclic GMP
Research Interests:
Research Interests: Thrombin, Humans, Platelet aggregation, Collagen, Mice, and 15 moreFemale, Animals, Male, Qualitative Study, Phosphodiesterase Inhibitors, European, Platelet Rich Plasma, Hydrazones, Cyclic nucleotides, Rabbits, Structure activity Relationship, Bleeding Time, Arachidonic Acid, Molecular Structure, and Sodium Nitroprusside
Research Interests:
Research Interests:
... Permissions & Reprints. Separation of three cyclic-nucleotide-phosphodiesterases from bovine aorta. B. Ilien , A. Stierlé , C. Lugnier , JC Stoclet and Y. Landry. ... 3. Chasin, M. and Harris, DN (1976) in Advances in cyclic... more
... Permissions & Reprints. Separation of three cyclic-nucleotide-phosphodiesterases from bovine aorta. B. Ilien , A. Stierlé , C. Lugnier , JC Stoclet and Y. Landry. ... 3. Chasin, M. and Harris, DN (1976) in Advances in cyclic nucleotide research, vol 7, pp 225264. ...