Sinta Murti

Dispepsia menempati urutan ketiga sebagai penyakit yang paling sering dilaporkan di Kalimantan Timur tahun 2017. Berbagai faktor risiko dikaitkan dengan kejadian dispepsia fungsional satu diantaranya yaitu stres. Penelitian ini dilakukan untuk mengetahui hubungan tingkat stres dengan kejadian dispepsia fungsional serta bersifat analitik dengan menggunakan pendekatan cross sectional. Pengambilan sampel dilakukan dengan consecutive sampling dan pengumpulan data menggunakan kuesioner kriteria Roma IV untuk dispepsia fungsional dan stres dari ISMA. Analisis data menggunakan uji Chi-Square. Dari 173 orang responden, 62 orang (35,8%) mengalami dispepsia fungsional. Didapatkan hubungan tingkat stres dengan kejadian dispepsia fungsional p-value 0,000 (p

Background: Lack of simple, rapid, and reliable point-of-care (POC) test hampers large-scale diagnosis and treatment of hepatitis C virus (HCV) infection and pose a challenge for its elimination as a public health threat. This study aimed to evaluate Cepheid Xpert® HCV Viral Load performance in comparison to Roche Cobas® TaqMan® HCV Test using HCV-samples with various genotypes in Indonesia.Methods: Viral load (VL) quantification was performed on 243 anti-HCV positive patients’ samples using both Xpert and Roche HCV tests, followed by HCV genotyping by reverse hybridization. Strength of relationship between the assays was measured by Pearson correlation coefficient, while level of agreement was analyzed by Deming regression and Bland-Altman plot analysis using log10-transformed VL values.Results: Quantifiable VL was detected in 180/243 (74.1%), with Xpert sensitivity of 100% (95% CI 0.98, 1.00) and specificity of 98.41% (95% CI 0.91, 0.99), while HCV genotypes were determined in 172...

Dyspepsia is a term that describes symptomps of upper middle abdominal discomfort. The risk factor that often associated with the incidence of functional dyspepsia is dietary factor. This study was conducted to determine the correlation between dietary pattern with the incidence of functional dyspepsia and this research was analytic using cross sectional approach. Sampling was done by consecutive sampling and the data was collected using questionnaire Rome IV criteria for dyspepsia functional and dietary pattern. It was analysed by Chi-Square test. Out of 173 respondents, 62 (35.8%) had functional dyspepsia. Analysis of  dietary pattern and the incidence of functional dyspepsia  for meal schedules obtained p-value 0.039(p <0.05) and for types of food and beverages obtained p-value 0.149(p> 0.05). There is a correlation of dietary pattern for meal schedules and functional dyspepsia, no correlation of dietary pattern for types of food and beverages and functional dyspepsia.

Background: Colorectal cancer is a malignancy originating from the colon tissue. The incidence of colorectal cancer was recorded at 396,914 new cases with 234,511 deaths and the fourth rank of all types of cancer cases in Indonesia. This study aims to determine the relationship between age and histopathological features and stage when diagnosed with colorectal cancer at Abdul Wahab Sjahranie Hospital, Samarinda. Methods: The study design was retrospective analytic with a cross sectional study approach. The research data came from the medical records of colorectal cancer patients at Abdul Wahab Sjahranie Hospital, Samarinda in 2017-2020. Results: A total sample size of 71 samples. Data analysis statistically showed the relationship between age and stage at diagnosis with p = 0.004 (p = 0.05). Conclusion: The relationship between age and stage at diagnosis of colorectal cancer patients at Abdul Wahab Sjahranie Hospital, Samarinda. Keywords: Colorectal Cancer, Age, Stage

Liver cirrhosis is described as a diffused pathological process which marked with fibrosis and architectural changes of normal liver that becomes an abnormal nodular structure. Liver cirrhosis is caused by chronic liver disease of virus nor non virus. Thrombocytopenia is a hematology abnormality which frequently found on liver cirrhosis patients. Severity level and prognosis of liver cirrhosis can be determined by Child-Pugh classification. This research aims to know the difference of mean platelet count on liver cirrhosis patients based on Child-Pugh classification. It applied analytic observational method with cross-sectional design. The data was taken from medical records of patients at Abdul Wahab Sjahranie Hospital in Samarinda of 2018-2020 period. Statistical analysis was using Kruskal-Wallis test. The results showed liver cirrhosis patients in Child-Pugh C is at most. Mean platelet count of liver cirrhosis with Child-Pugh A is 73.250/?l, Child-Pugh B is 126.370/?l, and Child-...

Esophageal variceal bleeding is a complication that frequently occurs in patients with hepatic cirrhosis. Endoscopic ligation procedure  was primary perfomed for esophageal varices. Liver function abnormalities in cirrhosis cause a disorder of hemostasis resulting in a decrease in platelet count. The Limitations of platelet counts for endoscopy are obstacles when the procedure will be performed. The purpose of this study was to determine the relationship of platelet count to the incidence of bleeding during variceal ligation in patients with hepatic cirrhosis at Rumah Sakit Abdul Wahab Sjahranie Samarinda. The study was retrospective analytic with a cross sectional approach using purposive sampling using patient secondary data. Data analysis using Chi Square test (Fisher Exact Test). The results of the statistical analysis shows that p = 0.604 (> 0.05). There was no correlation between platelet count and the incidence of bleeding during esophageal varicose ligation in patients wi...

Hepatocellular carcinoma (HCC) is a primary liver cancer that resulted from abnormal hepatocyte proliferation. HCC ranked fifth in the incidence of cancer cases and was the fourth leading cause of cancer death in the world in 2018. HCC patients have a poor prognosis and a low survival rate. This study aims to discover the incidence and characteristics of hepatocellular carcinoma in Abdul Wahab Sjahranie Regional Public Hospital Samarinda. The study design is a retrospective descriptive study. Data were obtained from patients' medical records data from February 2017 – February 2020. The result of this study were 206 HCC patients. From 206 patients, 82,5% were male and the oldest age group was 50-59 years old (33,5%); Hepatitis B (62,6%) was the most prevalent risk factor; 60,7% patients showed an increased level of AFP; 43,7% matched Child-Pugh B classification; 22,3% showed stage B BCLC; the most commonly used therapy was no-intervention therapy (93,2%). Survival rate was signif...

Hepatitis C virus (HCV) infection large-scale diagnosis and treatment are hampered by lack of a simple, rapid, and reliable point-of-care (POC) test, which poses a challenge for the elimination of hepatitis C as a public health problem. This study aimed to evaluate Cepheid Xpert® HCV Viral Load performance in comparison with the Roche Cobas® TaqMan® HCV Test using serum samples of HCV-infected patients in Indonesia. Viral load quantification was performed on 243 anti-HCV positive patients’ samples using both Xpert HCV VL and Roche HCV tests, followed by HCV genotyping by reverse hybridization. Strength of the relationship between the assays was measured by Pearson correlation coefficient, while level of agreement was analyzed by Deming regression and Bland–Altman plot analysis using log10-transformed viral load values. Quantifiable viral load was detected in 180/243 (74.1%), with Xpert HCV VL sensitivity of 100% (95% CI 0.98, 1.00) and specificity of 98.4% (95% CI 0.91, 0.99) based ...

Liver cirrhosis is the last stage of chronic liver disease that is in the path of the disease can cause damage of liver function and/or portal hypertension. The prognosis of liver cirrhosis can be assessed by manifestations of liver function disorders with Child Pugh score that include the presence or absence of ascites, encephalopathy, bilirubin serum, albumin serum, and prothrombin time or INR, while portal hypertension also occurs in patient of cirrhosis can lead the formation of esophageal varices. APRI score has platelet count and AST serum as its variable is suspected to be related to the Child Pugh score in assessing prognosis of cirrhosis patients. This study purposed to find the relation between APRI score (Aspartate Aminotransferase-to-Platelet Ratio Index) and Child Pugh score. Purpose of this research is to find the relation between APRI score (Aspartate Aminotransferase-to-Platelet Ratio Index) and Child Pugh score and degree of esophageal varices in patients with cirrh...

Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) are life-threatening conditions frequently associated with chronic hepatitis B virus (HBV) infection in Asian countries, including Indonesia. HBV genotypes and several specific mutations are associated with disease progression. To clarify the geographical variation in viral characteristics, HBV genotypes and gene mutations were investigated in patients with advanced liver disease (ALD) in Samarinda, East Kalimantan, Indonesia. Sera were collected from 41 patients with ALD at Abdul Wahab Sjahranie Hospital and HBV carriers from Red Cross Center blood bank in Samarinda, and screened for hepatitis B surface antigen and hepatitis B e-antigen. Liver function data were obtained from the medical records from each patient. HBV genotype and gene mutations were determined by polymerase chain reaction sequencing. Analysis of HBV isolates indicated that genotype B was the most frequent genotype, at 85.4 and 97.8%, followed by C, at 14.6 an...