Background: The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group t... more Background: The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group to improve their health and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association between ‘blood-type’ diets and biomarkers of cardiometabolic health and whether an individual’s ABO genotype modifies any associations. Methods: Subjects (n = 1,455) were participants of the Toronto Nutrigenomics and Health study. Dietary intake was assessed using a one-month, 196-item food frequency questionnaire and a diet score was calculated to determine relative adherence to each of the four ‘Blood-Type’ diets. ABO blood group was determined by genotyping rs8176719 and rs8176746 in the ABO gene. ANCOVA, with age, sex, ethnicity, and energy intake as covariates, was used to compare cardiometabolic biomarkers across tertiles of each ‘Blood-Type’ diet score. Results: Adherence to the Type-A diet was associated with lower BMI, waist circumference, blood pressure, serum cholesterol, triglycerides, insulin, HOMA-IR and HOMA-Beta (P,0.05). Adherence to the Type-AB diet was also associated with lower levels of these biomarkers (P,0.05), except for BMI and waist circumference. Adherence to the Type-O diet was associated with lower triglycerides (P,0.0001). Matching the ‘Blood-Type’ diets with the corresponding blood group did not change the effect size of any of these associations. No significant association was found for the Type-B diet. Conclusions: Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk factors, but these associations were independent of an individual’s ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis.
The spatial and temporal coordination of the many events required for osteogenic cells to create ... more The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells havemechanisms to carefullymonitor events in the extracellular environment and have the ability to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of hydroxyapatite mineral, Ca10(PO4)6(OH)2, a number of studies have also suggested it is required in the events preceding mineralization. However, contrasting results, physiological relevance, and the lack of a clearmechanism(s) have created some debate as to the significance of elevated phosphate in the differentiation process.More recently, a number of studies have begun to shed light on possible cellular andmolecular consequences of elevated intracellular inorganic phosphate. These results suggest amodel inwhich the generation of inorganic phosphate during osteoblast differentiationmay in and of itself represent a signal capable of facilitating the temporal coordination of expression and regulation ofmultiple factors necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment. J. Cell. Biochem. 90: 234–243, 2003. Published 2003 Wiley-Liss, Inc. y Key words: inorganic phosphate; osteoblast differentiation; calcium; osteopontin; alkaline phosphatase
Background: The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group t... more Background: The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group to improve their health and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association between ‘blood-type’ diets and biomarkers of cardiometabolic health and whether an individual’s ABO genotype modifies any associations. Methods: Subjects (n = 1,455) were participants of the Toronto Nutrigenomics and Health study. Dietary intake was assessed using a one-month, 196-item food frequency questionnaire and a diet score was calculated to determine relative adherence to each of the four ‘Blood-Type’ diets. ABO blood group was determined by genotyping rs8176719 and rs8176746 in the ABO gene. ANCOVA, with age, sex, ethnicity, and energy intake as covariates, was used to compare cardiometabolic biomarkers across tertiles of each ‘Blood-Type’ diet score. Results: Adherence to the Type-A diet was associated with lower BMI, waist circumference, blood pressure, serum cholesterol, triglycerides, insulin, HOMA-IR and HOMA-Beta (P,0.05). Adherence to the Type-AB diet was also associated with lower levels of these biomarkers (P,0.05), except for BMI and waist circumference. Adherence to the Type-O diet was associated with lower triglycerides (P,0.0001). Matching the ‘Blood-Type’ diets with the corresponding blood group did not change the effect size of any of these associations. No significant association was found for the Type-B diet. Conclusions: Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk factors, but these associations were independent of an individual’s ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis.
The spatial and temporal coordination of the many events required for osteogenic cells to create ... more The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells havemechanisms to carefullymonitor events in the extracellular environment and have the ability to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of hydroxyapatite mineral, Ca10(PO4)6(OH)2, a number of studies have also suggested it is required in the events preceding mineralization. However, contrasting results, physiological relevance, and the lack of a clearmechanism(s) have created some debate as to the significance of elevated phosphate in the differentiation process.More recently, a number of studies have begun to shed light on possible cellular andmolecular consequences of elevated intracellular inorganic phosphate. These results suggest amodel inwhich the generation of inorganic phosphate during osteoblast differentiationmay in and of itself represent a signal capable of facilitating the temporal coordination of expression and regulation ofmultiple factors necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment. J. Cell. Biochem. 90: 234–243, 2003. Published 2003 Wiley-Liss, Inc. y Key words: inorganic phosphate; osteoblast differentiation; calcium; osteopontin; alkaline phosphatase
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Papers by Duhita J R Perdhani
and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based
dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association
between ‘blood-type’ diets and biomarkers of cardiometabolic health and whether an individual’s ABO genotype modifies
any associations.
Methods: Subjects (n = 1,455) were participants of the Toronto Nutrigenomics and Health study. Dietary intake was
assessed using a one-month, 196-item food frequency questionnaire and a diet score was calculated to determine relative adherence to each of the four ‘Blood-Type’ diets. ABO blood group was determined by genotyping rs8176719 and
rs8176746 in the ABO gene. ANCOVA, with age, sex, ethnicity, and energy intake as covariates, was used to compare cardiometabolic biomarkers across tertiles of each ‘Blood-Type’ diet score.
Results: Adherence to the Type-A diet was associated with lower BMI, waist circumference, blood pressure, serum cholesterol, triglycerides, insulin, HOMA-IR and HOMA-Beta (P,0.05). Adherence to the Type-AB diet was also associated with lower levels of these biomarkers (P,0.05), except for BMI and waist circumference. Adherence to the Type-O diet was associated with lower triglycerides (P,0.0001). Matching the ‘Blood-Type’ diets with the corresponding blood group did not change the effect size of any of these associations. No significant association was found for the Type-B diet.
Conclusions: Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk
factors, but these associations were independent of an individual’s ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis.
mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product,
demand that these cells havemechanisms to carefullymonitor events in the extracellular environment and have the ability
to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of
differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of
hydroxyapatite mineral, Ca10(PO4)6(OH)2, a number of studies have also suggested it is required in the events preceding
mineralization. However, contrasting results, physiological relevance, and the lack of a clearmechanism(s) have created
some debate as to the significance of elevated phosphate in the differentiation process.More recently, a number of studies
have begun to shed light on possible cellular andmolecular consequences of elevated intracellular inorganic phosphate.
These results suggest amodel inwhich the generation of inorganic phosphate during osteoblast differentiationmay in and
of itself represent a signal capable of facilitating the temporal coordination of expression and regulation ofmultiple factors
necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate
during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the
changing extracellular environment. J. Cell. Biochem. 90: 234–243, 2003. Published 2003 Wiley-Liss, Inc.
y
Key words: inorganic phosphate; osteoblast differentiation; calcium; osteopontin; alkaline phosphatase
and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based
dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association
between ‘blood-type’ diets and biomarkers of cardiometabolic health and whether an individual’s ABO genotype modifies
any associations.
Methods: Subjects (n = 1,455) were participants of the Toronto Nutrigenomics and Health study. Dietary intake was
assessed using a one-month, 196-item food frequency questionnaire and a diet score was calculated to determine relative adherence to each of the four ‘Blood-Type’ diets. ABO blood group was determined by genotyping rs8176719 and
rs8176746 in the ABO gene. ANCOVA, with age, sex, ethnicity, and energy intake as covariates, was used to compare cardiometabolic biomarkers across tertiles of each ‘Blood-Type’ diet score.
Results: Adherence to the Type-A diet was associated with lower BMI, waist circumference, blood pressure, serum cholesterol, triglycerides, insulin, HOMA-IR and HOMA-Beta (P,0.05). Adherence to the Type-AB diet was also associated with lower levels of these biomarkers (P,0.05), except for BMI and waist circumference. Adherence to the Type-O diet was associated with lower triglycerides (P,0.0001). Matching the ‘Blood-Type’ diets with the corresponding blood group did not change the effect size of any of these associations. No significant association was found for the Type-B diet.
Conclusions: Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk
factors, but these associations were independent of an individual’s ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis.
mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product,
demand that these cells havemechanisms to carefullymonitor events in the extracellular environment and have the ability
to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of
differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of
hydroxyapatite mineral, Ca10(PO4)6(OH)2, a number of studies have also suggested it is required in the events preceding
mineralization. However, contrasting results, physiological relevance, and the lack of a clearmechanism(s) have created
some debate as to the significance of elevated phosphate in the differentiation process.More recently, a number of studies
have begun to shed light on possible cellular andmolecular consequences of elevated intracellular inorganic phosphate.
These results suggest amodel inwhich the generation of inorganic phosphate during osteoblast differentiationmay in and
of itself represent a signal capable of facilitating the temporal coordination of expression and regulation ofmultiple factors
necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate
during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the
changing extracellular environment. J. Cell. Biochem. 90: 234–243, 2003. Published 2003 Wiley-Liss, Inc.
y
Key words: inorganic phosphate; osteoblast differentiation; calcium; osteopontin; alkaline phosphatase