A capillary electrophoretic (CE) method for the baseline separation of the enantiomers of primaquine diphosphate (PQ) and quinocide (QC) (a major contaminant) in pharmaceutical formulations is proposed. Both components were separated... more
A capillary zone electrophoretic method has been developed and validated for the determination of the impurity quinocide (QC) in the antimalarial drug primaquine (PQ). Different buffer additives such as native cyclodextrins and crown... more
A micellar electrokinetic chromatography (MEKC) method for the simultaneous determination of the antiviral drugs acyclovir and valacyclovir and their major impurity, guanine, was developed. The influences of several factors (surfactant... more
A simple, rapid and validated capillary electrophoretic method has been developed for the separation and determination of ofloxacin and ornidazole in pharmaceutical formulations with detection at 230 nm. Optimal conditions for the... more
The antimalarial drug primaquine (PQ) and its contaminant, the positional isomer quinocide (QC) have been successfully separated using capillary electrophoresis with either β-cyclodextrin (β-CD) or 18-crown-6 ether (18C6) as chiral mobile... more
A rapid, simple and sensitive method for the determination of primaquine (PQ) using sodium 1,2-naphthoquinone-4-sulfonate (NQS) has been developed. The method is based on the formation of a brown color adduct from the reaction between... more
A rapid, simple and sensitive method for the determination of primaquine (PQ) using sodium 1,2-naphthoquinone-4-sulfonate (NQS) has been developed. The method is based on the formation of a brown color adduct from the reaction between PQ and NQS. The nucleophilic substitution reaction proceeds quantitatively at pH 10 buffer solution with absorption maximum at 485 nm. The calibration curve is linear over the range 10-60μg/mL and describes by the regression equation A꞊ 0.005X+ 0.055C with a regression coefficient 0.9998. The limit of detection and quantity are 3.2 μg/mL and 9.9 μg∕ mL respectively. The method is simple and can be applied for determination of PQ in pharmaceutical formulation in quality control laboratories