R. Iqbal,a* M. Zareef,a S. Ahmed,b JH Zaidi,a M. Arfan,a M. Shafiqueb and NA Al-Masoudic aDepartm... more R. Iqbal,a* M. Zareef,a S. Ahmed,b JH Zaidi,a M. Arfan,a M. Shafiqueb and NA Al-Masoudic aDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan bDepartment of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan cFachbereich Chemie, ...
ABSTRACT Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the is... more ABSTRACT Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 μm, respectively.
Pistacia integerrima Stewart in traditionally used as folk remedy for various pathological condit... more Pistacia integerrima Stewart in traditionally used as folk remedy for various pathological conditions including diabetes. In order to identify the bioactive compound responsible for its folk use in diabetes, a phytochemical and biological study was conducted. Pistagremic acid (PA) was isolated from the dried galls extract of P. integerrima. Strong α-glucosidase inhibitory potential of PA was predicted using its molecular docking simulations against yeast α-glucosidase as a therapeutic target. Significant experimental α-glucosidase ...
Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with β-si- tosterol, γ-sitosterol, fr... more Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with β-si- tosterol, γ-sitosterol, friedelin and β-amyrin were isolated from the aerial parts of Hypericum monogynum. Whereas compound 1 was isolated for the first time from natural sources, flavanonol 3 was not found before in these species.
R. Iqbal,a* M. Zareef,a S. Ahmed,b JH Zaidi,a M. Arfan,a M. Shafiqueb and NA Al-Masoudic aDepartm... more R. Iqbal,a* M. Zareef,a S. Ahmed,b JH Zaidi,a M. Arfan,a M. Shafiqueb and NA Al-Masoudic aDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan bDepartment of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan cFachbereich Chemie, ...
ABSTRACT Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the is... more ABSTRACT Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 μm, respectively.
Pistacia integerrima Stewart in traditionally used as folk remedy for various pathological condit... more Pistacia integerrima Stewart in traditionally used as folk remedy for various pathological conditions including diabetes. In order to identify the bioactive compound responsible for its folk use in diabetes, a phytochemical and biological study was conducted. Pistagremic acid (PA) was isolated from the dried galls extract of P. integerrima. Strong α-glucosidase inhibitory potential of PA was predicted using its molecular docking simulations against yeast α-glucosidase as a therapeutic target. Significant experimental α-glucosidase ...
Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with β-si- tosterol, γ-sitosterol, fr... more Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with β-si- tosterol, γ-sitosterol, friedelin and β-amyrin were isolated from the aerial parts of Hypericum monogynum. Whereas compound 1 was isolated for the first time from natural sources, flavanonol 3 was not found before in these species.
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Papers by Prof. Dr. M. Arfan, Chemistry Arfan