Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in ad... more Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils. Therefore, melanoma cells (B16F10) were pretreated with vehicle, LNC, AcE or AcE-LNC for 24 h, washed and, further, cocultured for 18 h with peritoneal neutrophils obtained from C57Bl/6 mice. Melanoma cells were able to internalize the LNC or AcE-LNC after 2 h of incubation. LNC or AcE-LNC pretreatments did not cause melanoma cells death, but led melanoma cells to b...
... 5. Exploring the Supramolecular Coordination Chemistry-Based Approach for Nanotechnology. Ken... more ... 5. Exploring the Supramolecular Coordination Chemistry-Based Approach for Nanotechnology. Kenneth D. Karlin. Henrique E. Toma,; Koiti Araki. ... Author Information. Instituto de Quimica, Universidade de São Paulo CEP 05513-970 São Paulo, Brazil. Publication History. ...
Abstract Tetra (3-pyridyl) porphyrazine is soluble in trifluoroethanol yielding intense blue solu... more Abstract Tetra (3-pyridyl) porphyrazine is soluble in trifluoroethanol yielding intense blue solutions. The electronic spectra exhibit the characteristic Soret and Q bands around 330 and 610 nm, respectively; however, the absorption profile is strongly dependent on the ...
... In the case of a rodlike nematic mesogenic porphyrin phase, Bard and co-workers reported that... more ... In the case of a rodlike nematic mesogenic porphyrin phase, Bard and co-workers reported that the value increases to about 4 Å. ... Fan, FF; Bard, AJ J. Am. Chem. Soc. 1980, 102, 5138. [ACS Full Text ACS Full Text ]. (3) Kampas, FJ; Yamashita, K.; Fajer, J. Nature 1980, 284, 40. ...
ABSTRACT The light-to-electricity conversion efficiencies of the new (Bu4N)3[Ru(dcbpy)2(tmtH2)], ... more ABSTRACT The light-to-electricity conversion efficiencies of the new (Bu4N)3[Ru(dcbpy)2(tmtH2)], (Bu4N)4[Ru(dcbpy)2(tmtH)] and (Bu4N)5[Ru(dcbpy)2(tmt)] complexes, where dcbpy = 2,2′-bipyridyl-4,4′-dicarboxylate and tmt = 2,4,6-trimercapto-1,3,5-triazine, were comparable with those obtained with the N719 dye. Furthermore, the contribution of two MLCT and a LMCT charge-transfer band to the energy conversion process was revealed by deconvolution of the photoaction spectra, indicating that they are the first ruthenium dyes presenting long distance photo-injection from a ligand-to-metal charge-transfer excited state.
Traditional Feigl&amp... more Traditional Feigl's spot tests can be greatly improved with the aid of gold nanoparticles and Raman probes, by monitoring the changes in the surface enhanced Raman scattering (SERS) of the analytes directly applied on a filter paper previously impregnated with the selective organic reagent. As a proof of concept, diphenylthiocarbazone (dithizone) was treated with citrate stabilized gold nanoparticles and employed in paper spot tests for a variety of transition and heavy metal ions. Below 10(-5) mol L(-1), only mercury(II) ions were able to displace the dithizone molecules from the "coordination shell" of the gold nanoparticles, leading to a systematic decay of the Raman signals. Because of the huge enhancement of the dithizone vibrational peaks, the SERS spot tests allowed the detection of picograms of Hg(2+) ions.
The [Ru(edta)(ddtc)]2− complex, where ddtc− represents a bidentate diethyldithiocarbamate ligand,... more The [Ru(edta)(ddtc)]2− complex, where ddtc− represents a bidentate diethyldithiocarbamate ligand, has been characterized in one solid state and in solution. Reversible electrochemical and spectroelectrochemical behavour has been observed for the complex, with E0(RuIII/RuII) = −0.22V versus S.H.E. A formation mechanism starting from [RuIII(edta)(H2O)]− and ddtc− is proposed, involying a monodendate binding step, with kf = 17 M−1 s−1, followed by rapid ring closure.
ABSTRACT In this paper, a new composite sensor for e-nose application is described. A modificatio... more ABSTRACT In this paper, a new composite sensor for e-nose application is described. A modification in the regular pair conductive polymer/Lewis acid dopant is proposed, replacing the acid by free-base or metallated porphyrins. Sensors doped with different porphyrin species, using the same conductive polymer, led to a huge variation in response to selected analytes. Two different arrays (doped with free-base and metallated porphyrins) using these sensors were able to identify four organic solvents, used as standard analytes: propanone, ethyl acetate, ethanol and toluene. Both of them could distinguish the tested vapours.
... Clieni. SOC. Japan, 55, 797 (1982). HE Toma, PS Santos, MPD Mattioli and LA Oliveira, Polyhed... more ... Clieni. SOC. Japan, 55, 797 (1982). HE Toma, PS Santos, MPD Mattioli and LA Oliveira, Polyhedron. 6, 603 (1987). AA Diamantis and JV Dubrawski, Iriorg. ClIenz.. 20, 1142 (1981). MM Taqui Khan, A. Hussain, G. Ramachandraiah and MA hloiz, Inorg. Cheni.. 25,3023 (1986). ...
Magnetic AFM probes known as MAClevers® were employed for sensing picogram amounts of magnetic na... more Magnetic AFM probes known as MAClevers® were employed for sensing picogram amounts of magnetic nanoparticles, based on the cantilever frequency shifts resulting from the magnetically induced adsorption of mass. By using organothiol functionalized magnetic nanoparticles, this analytical strategy was successfully extended to the detection of gold nanoparticles, as confirmed by confocal Raman microscopy.
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in ad... more Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils. Therefore, melanoma cells (B16F10) were pretreated with vehicle, LNC, AcE or AcE-LNC for 24 h, washed and, further, cocultured for 18 h with peritoneal neutrophils obtained from C57Bl/6 mice. Melanoma cells were able to internalize the LNC or AcE-LNC after 2 h of incubation. LNC or AcE-LNC pretreatments did not cause melanoma cells death, but led melanoma cells to b...
... 5. Exploring the Supramolecular Coordination Chemistry-Based Approach for Nanotechnology. Ken... more ... 5. Exploring the Supramolecular Coordination Chemistry-Based Approach for Nanotechnology. Kenneth D. Karlin. Henrique E. Toma,; Koiti Araki. ... Author Information. Instituto de Quimica, Universidade de São Paulo CEP 05513-970 São Paulo, Brazil. Publication History. ...
Abstract Tetra (3-pyridyl) porphyrazine is soluble in trifluoroethanol yielding intense blue solu... more Abstract Tetra (3-pyridyl) porphyrazine is soluble in trifluoroethanol yielding intense blue solutions. The electronic spectra exhibit the characteristic Soret and Q bands around 330 and 610 nm, respectively; however, the absorption profile is strongly dependent on the ...
... In the case of a rodlike nematic mesogenic porphyrin phase, Bard and co-workers reported that... more ... In the case of a rodlike nematic mesogenic porphyrin phase, Bard and co-workers reported that the value increases to about 4 Å. ... Fan, FF; Bard, AJ J. Am. Chem. Soc. 1980, 102, 5138. [ACS Full Text ACS Full Text ]. (3) Kampas, FJ; Yamashita, K.; Fajer, J. Nature 1980, 284, 40. ...
ABSTRACT The light-to-electricity conversion efficiencies of the new (Bu4N)3[Ru(dcbpy)2(tmtH2)], ... more ABSTRACT The light-to-electricity conversion efficiencies of the new (Bu4N)3[Ru(dcbpy)2(tmtH2)], (Bu4N)4[Ru(dcbpy)2(tmtH)] and (Bu4N)5[Ru(dcbpy)2(tmt)] complexes, where dcbpy = 2,2′-bipyridyl-4,4′-dicarboxylate and tmt = 2,4,6-trimercapto-1,3,5-triazine, were comparable with those obtained with the N719 dye. Furthermore, the contribution of two MLCT and a LMCT charge-transfer band to the energy conversion process was revealed by deconvolution of the photoaction spectra, indicating that they are the first ruthenium dyes presenting long distance photo-injection from a ligand-to-metal charge-transfer excited state.
Traditional Feigl&amp... more Traditional Feigl's spot tests can be greatly improved with the aid of gold nanoparticles and Raman probes, by monitoring the changes in the surface enhanced Raman scattering (SERS) of the analytes directly applied on a filter paper previously impregnated with the selective organic reagent. As a proof of concept, diphenylthiocarbazone (dithizone) was treated with citrate stabilized gold nanoparticles and employed in paper spot tests for a variety of transition and heavy metal ions. Below 10(-5) mol L(-1), only mercury(II) ions were able to displace the dithizone molecules from the "coordination shell" of the gold nanoparticles, leading to a systematic decay of the Raman signals. Because of the huge enhancement of the dithizone vibrational peaks, the SERS spot tests allowed the detection of picograms of Hg(2+) ions.
The [Ru(edta)(ddtc)]2− complex, where ddtc− represents a bidentate diethyldithiocarbamate ligand,... more The [Ru(edta)(ddtc)]2− complex, where ddtc− represents a bidentate diethyldithiocarbamate ligand, has been characterized in one solid state and in solution. Reversible electrochemical and spectroelectrochemical behavour has been observed for the complex, with E0(RuIII/RuII) = −0.22V versus S.H.E. A formation mechanism starting from [RuIII(edta)(H2O)]− and ddtc− is proposed, involying a monodendate binding step, with kf = 17 M−1 s−1, followed by rapid ring closure.
ABSTRACT In this paper, a new composite sensor for e-nose application is described. A modificatio... more ABSTRACT In this paper, a new composite sensor for e-nose application is described. A modification in the regular pair conductive polymer/Lewis acid dopant is proposed, replacing the acid by free-base or metallated porphyrins. Sensors doped with different porphyrin species, using the same conductive polymer, led to a huge variation in response to selected analytes. Two different arrays (doped with free-base and metallated porphyrins) using these sensors were able to identify four organic solvents, used as standard analytes: propanone, ethyl acetate, ethanol and toluene. Both of them could distinguish the tested vapours.
... Clieni. SOC. Japan, 55, 797 (1982). HE Toma, PS Santos, MPD Mattioli and LA Oliveira, Polyhed... more ... Clieni. SOC. Japan, 55, 797 (1982). HE Toma, PS Santos, MPD Mattioli and LA Oliveira, Polyhedron. 6, 603 (1987). AA Diamantis and JV Dubrawski, Iriorg. ClIenz.. 20, 1142 (1981). MM Taqui Khan, A. Hussain, G. Ramachandraiah and MA hloiz, Inorg. Cheni.. 25,3023 (1986). ...
Magnetic AFM probes known as MAClevers® were employed for sensing picogram amounts of magnetic na... more Magnetic AFM probes known as MAClevers® were employed for sensing picogram amounts of magnetic nanoparticles, based on the cantilever frequency shifts resulting from the magnetically induced adsorption of mass. By using organothiol functionalized magnetic nanoparticles, this analytical strategy was successfully extended to the detection of gold nanoparticles, as confirmed by confocal Raman microscopy.
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