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2016, International Journal of Clinical Biochemistry and Research
Background: Lactate dehydrogenase (LDH) enzyme is found in almost every tissues of the body and its level is increased in serum in many tissue damaging pathological disorders. Patients with chronic cough mostly have history of cigarette smoking and prone to airway inflammation. Documentary studies shows cigarette smoking is associated with altered lipid profile. The aim of the present study is to assess whether there is alteration in the concentration of serum lactate dehydrogenase and lipid profile in patients with chronic cough by estimation of lactate dehydrogenase level and lipid profile in serum. Material and Methods: It is a case control study consisting of 50 cases with chronic cough compared with 50 healthy controls. Serum level of lactate dehydrogenase, total cholesterol, and triglyceride, LDL, VLDL and HDL were estimated in both the study groups. Statistical analysis was done by using unpaired t test. Values were expressed as means and standard deviation (SD). Results: Sta...
The Clinical Respiratory Journal
Serum LDH in chronic cough: a potential marker of airway inflammation2011 •
2017 •
To estimate the serum and salivary lactate dehydrogenase levels in cigarette smokers and non-smokers. In this study lactate dehydrogenase levels were estimated in 30 healthy individuals with no tobacco related habits and in 30 patients with history of smoking cigarettes for a minimum of 2 years using Spectrophotometry. The mean values for serum and salivary lactate dehydrogenase levels were higher in cigarette smokers when compared to non-smokers. Serum lactate dehydrogenase levels on comparison between the groups was statistically significant (p=0.04). The values of salivary lactate dehydrogenase levels between the groups was highly significant (p<0.001). Cigarette smoking leads to an increase in serum as well as salivary Lactate dehydrogenase levels as indicator of tissue damage in the oral cavity. The present study indicates saliva as a better test medium than serum in determination of lactate dehydrogenase levels.
Bangabandhu Sheikh Mujib Medical University journal
Lipid profile pattens in chronic obstructive pulmonary disease and its correlation with the severity of disease2022 •
This cross-sectional study was conducted to determine the serum lipid profiles in chronic obstructive pulmonary disease (COPD) patients and its correlation with the severity of COPD in the Department of Respiratory Medicine at Bangabandhu Sheikh Mujib Medical University. A total of 100 spirometric-confirmed cases of COPD were included. Fasting blood samples for lipid profiles were collected. To identify the association between severity of COPD with lipid profiles Pearson's correlation was used. Further multiple linear regression was done to identify the relation. The mean (standard deviation) age of the patients was 59.0 (10.7)years. The ratio of males and females was 19:1. The mean forced expiratory volume (liters) in 1 second (FEV1) was 55.1 (18.1). Most of the patients had stage II (48%) and stage III (36%) airflow obstruction. Plasma level of total cholesterol and triglyceride tend to increase, statistically non-significant, with stages of COPD. However, the association of plasma lipids becomes statistically significant with FEV1 when the effects of age, BMI, pack-year smoking, duration of illness are accounted in multiple linear regression analysis.
Respiratory Physiology & Neurobiology
Lactate dehydrogenase isoenzymes in patients with acute exacerbation of chronic obstructive pulmonary disease: An exploratory cross-sectional study2021 •
We aimed to evaluate differences in serum lactate dehydrogenase (LDH) isoenzymes between patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and other lower respiratory tract infections (LRTIs). Based on self-reported COPD diagnosis, 71 participants were divided into AECOPD (n = 38, 29 males, mean age 70.5 years) and LRTI (n = 33, 12 males, mean age 70.4 years) groups. Information on demographics, comorbidities, and COPD severity markers, as well as arterial blood gases and laboratory data were collected, while serum LDH electrophoresis was performed to examine the LDH isoenzymes. Adjusting for sex, age, comorbidities, degree of hypoxemia, inflammation markers, muscle and myocardial enzymes, and total serum LDH, the mean differences (95 % confidence intervals) in the ratios of serum LDH isoenzymes to total serum LDH between groups (LDHxAECOPD − LDHxLRTI) were statistically significant for LDH1 [4.9 (1.4 to 8.3)], LDH2 [3.0 (0.1 to 5.8)], LDH3 [−4.3 (−6.3 to −2.3)], and LDH4 [−3.2 (−4.9 to −1.5)]. A sum of LDH3 and LDH4 ratios below 29 % had the highest discriminative ability to classify a subject in the AECOPD group (AUC 0.841, sensitivity 76 %, specificity 87 %). Aerobic metabolic adaptive mechanisms in respiratory muscles during AECOPD could explain the above differences.
European Respiratory Journal
Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation1996 •
Clinical Infection and Immunity
Bronchoalveolar Wash: Proposal of a Cutting Point for Lactate Dehydrogenase in the Differential Diagnosis of Pulmonary DiseasesZagazig University Medical Journal
Lactate dehydrogenase as a predictor of bronchiolitis severity in children in teaching hospitals in Egypt2020 •
Journal of Periodontal Research
Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population2018 •
Bangladesh Journal of Medical Biochemistry
Lipid Profile Status of Chronic Obstructive Pulmonary Disease in Hospitalized Patients2013 •
The aim of this study was to evaluate the serum level of total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and high density lipoproteins, (HDL) in chronic obstructive pulmonary disease (COPD) patients admitted in National Institute of Disease of Chest and Hospital, Mohakhali, Dhaka during. January 2009 to January 2010. Twenty two patients with COPD and 22 healthy controls were included in this study. Total cholesterol, HDL and TG levels were determined with ILAB 1800 Chemistry Analyzer using ILAB test Reagents. LDL concentration was calculated using the Friedewald Equation. The mean level of TG was 150.04±29.66 mg/dl and 126.14±13.28 in COPD patients and healthy control, respectively. A statistically significant difference was found between the two groups (p<0.001). The mean level of TC was 181.83±20.11 mg/dl and 176.28±15.35 mg/dl in COPD patients and healthy control respectively (p<0.001). LDL level mean value was 116.12±14.26 mg/dl and 108.95±10.39 in CO...
Biomedicines
The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking StatusTobacco consumption is the most incriminated and studied risk factor for Chronic obstructive pulmonary disease (COPD), but other factors such as air pollution, are also linked to this disease. One of the known aspects of this chronic lung disease is that its occurrence is mainly due to the chronic inflammation of the airways. Lipid metabolism seems to be affected by smoking, with studies showing a correlation between this habit and high levels of triglycerides and low levels of high-density lipoprotein cholesterol (HDL-CHOL). Uric acid concentration is thought to reflect the antioxidative capacity of the body because it is the most abundant aqueous antioxidant. The aim of this study was to investigate the lipid profile and biochemical parameters of COPD patients in relation to smoking status. The present study was conducted between 2020 and 2021 in the Clinical Hospital of Pneumology in Iasi, Romania. Patients diagnosed with COPD (n = 52) were included and divided in three groups de...
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