910 Hypersensitivity Drug Reactions (HDR) In Latin America. Similarities and Differences Between Children and Adults Dr. Ricardo Cardona-Villa, MD 1 , Dr. Edgardo J. Jares, MD 2 , Dr. Maximiliano Gomez 3 , Dr. Luis Felipe C. Ensina, MD 4 , Dr. Mario Sanchez-Borges, MD, FAAAAI 5 , Dr. Alfredo Arias Cruz 6 , Dr. Carlos Serrano 7 , Dr. Mabel Noemi Cuello, MD 8 , Ivan Cherrez 9 , Dr. Andrea Zanacchi 10 , Prof. Alicia De Falco 11 , Dr. Silvana Monsell 2 , Dr. Adolfo Salvatierra 12 , Dr. Susana Barayazarra 10 , Dr. Susana Diez-Zuloaga 1 , Dr. Blanca Maria Morfin-Maciel, MD 13 , Dr. Paola Toche Pinaud 14 , Dr. Sandra Gonzalez Dıaz 6 , Dr. Juan F. Schuhl, MD, FAAAAI 15 ; 1 Univer- sidad de Antioquia, Medellin, Colombia, 2 C.M.P. SA, Buenos Aires, Argentina, 3 Hospital San Bernardo, Salta, Argentina, 4 Universidade Fed- eral de S~ao Paulo, S~ao Paulo, Brazil, 5 Clinica El Avila, 6a transversal Alta- mira, piso 8, consultorio 803, Caracas., Caracas, Venezuela, 6 Hospital Universitario, Monterrey, Mexico, 7 Fundacion Valle del Lili, Cali, Colombia, 8 Consultorios San Juan, San Juan, Argentina, 9 Respiralab - Hos- pital Kennedy, Guayaquil, Ecuador, 10 Nuevo Hospital San Roque, Cordoba, Argentina, 11 Universidad Nacional de La Plata, La Plata, Argentina, 12 Fun- dair, San Luis, Argentina, 13 Hospital Mocel, Mexico City, Mexico, 14 Clınica Las Condes, Santiago, Chile, 15 British Hospital, Montevideo, Uruguay. RATIONALE: HDR are frequent motives for consultation in Allergology services. Possible etiologic factors and clinical presentation differences between Latin American children and adults have not been described yet. METHODS: An observational cross sectional study using a modified ENDA questionnaire was implemented in 19 allergology units in 11 Latin- American countries, reporting patients presenting HDR in the last year before consultation. Causal relationship was categorized according to WHO-UMC Causality Categories: certain, probable, possible, unlikely and conditional. RESULTS: 727 patients, 144 (19.8%) of them under 18 years old, presented 732 reactions. Female gender was 71.7% in adults, and 50% in children. Atopic history was present in 44.9 and 63.8% and a history of previous drug reaction in 31.9 and 36.9% of adults and children, respectively. Fourteen percent of adult, and 10.7% of children had presented previous reactions with the same drug. The clinical picture of the reaction in adults and children was angioedema in 47.9 and 48.6%, urticaria in 44.5 and 41.8%, maculopapular and macular exanthema in 20.3 and 22.6 %, erythema multiforme and SJS in 3.6 and 2.7% respectively. Certain and probable causal relationships were attributed in adults and children to NSAIDs in 55.7 and 60.3 %, beta lactams in 11.2 and 19.8%, non beta lactam antibiotics in 8.4 and 2.5 %, anticonvulsants in 3.2 and 1.7%, chemotherapy 0.8 and 2.5% of patients, respectively. CONCLUSIONS: Female sex was predominant in adults but not in children. NSAIDs and antibiotics were the drugs implicated in more than 75% of patients. Beta lactam antibiotics were more frequently involved in children. 911 Copy Number Variations In ALOX5 and PTGER1 Genes Are Associated With Susceptibility To AERD and Mnsaid-UA Mrs. Maria Del Carmen Plaza Seron, Bsc 1 , Dr. Pedro Ayuso Parejo, PhD 1 , Dr. Natalia Blanca-Lopez, MD, PhD 1 , Dr. Inmaculada Do~na, MD, PhD 2 , Dr. Jose A. Cornejo-Garcia, PhD 3 , Dr. Marıa Jose Torres, MD, PhD 2 , Dr. Javier Fernandez 4 , Dr. Jose Julio Laguna, MD, PhD 5 , Veronique Godineau 3 , Ms. Miriam Osorio 6 , Mrs. Luisa Galindo, RN 2 , Dr. Gabriela Canto, MD, PhD 1 , Dr. Miguel Blanca, MD, PhD 2 ; 1 Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 2 Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3 Research Laboratory, Car- los Haya Hospital, Malaga, Spain, 4 UMH Alicante G.University Hospital - Allergy Sect., Alicante, Spain, 5 De La Cruz Roja Hospital, Madrid, Spain, 6 Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain. RATIONALE: Aspirin-exacerbated respiratory disease (AERD) and Multiple NSAID–triggered urticaria and/or angioedema and anaphylaxis in patients without pre-existing chronic urticaria (MNSAID-UA) are the main manifestations of hypersensitivity reactions. Both are mediated by a non-specific immunological mechanism based on NSAIDs capacity to inhibit COX-1 and evoke an unbalance of metabolic pathway of arachidonic acid. Copy number variations (CNVs) are DNA segments present at variable copy number that may affect the expression of genes and be associated with susceptibility to diseases. The aim of this study was to analyze association of CNV in genes implicated in arachidonic acid pathway with MNSAID-UA and AERD. METHODS: We studied a total of 150 patients with AERD, 310 MNSAID-UA and 315 tolerant controls. We used TaqManÒ copy number assays to analyze CNVs in PTGS1, PTGS2, LTC4S, ALOX5 and PTGER1-4 genes. The results were analyzed using the Copy Caller Software and SPSS 11.5 program. RESULTS: We found differences in ALOX5 and PTGER1 genes. All con- trols showed 2 copies of each gene analyzed. Concerning to ALOX5, we identified 7 AERD patients (5.0%; AERD vs. Controls P< 0.001) and 13 MNSAIDS-UA patients (4.17%; MNSAID-UA vs. Controls P< 0.001) with a single copy of this gene. Regarding to PTGER1, we identified 19 MNSAID-UA patients (6.11%; MNSAID-UA vs. Controls P< 0.0001) with a single copy of the gene, no AERD patients showed a single copy. CONCLUSIONS: We found statistically significant differences in CNVs of genes ALOX5 and PTGER1 between healthy controls and MNSAID-UA and AERD. Whether these variations imply a dysfunctional gene expres- sion require further studies. 912 Association Study Of Genes Involved In Mast Cell Activation and Mnsaid-UA Dr. Pedro Ayuso Parejo, PhD 1 , Mrs. Maria del Carmen Plaza- Seron, Bsc 1 , Dr. Inmaculada Do~na, MD, PhD 2 , Dr. Natalia Blanca- Lopez, MD, PhD 1 , Dr. Jose A. Cornejo-Garcia, PhD 3 , Dr. Maria J. Torres, MD, PhD 2 , Dr. Javier Fernandez 4 , Dr. Jose Julio Laguna, MD, PhD 5 , Ms. Miriam Osorio 6 , Veronique Godineau 3 , Mrs. Luisa Galindo, RN 2 , Dr. Cristobalina Mayorga, PhD 3 , Dr. Gabriela Canto, MD, PhD 1 , Dr. Miguel Blanca, MD, PhD 2 ; 1 Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 2 Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3 Research Laboratory, Carlos Haya Hospital, Malaga, Spain, 4 UMH Alicante G.University Hospital - Allergy Sect., Ali- cante, Spain, 5 De La Cruz Roja Hospital, Madrid, Spain, 6 Research Lab- oratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain. RATIONALE: Non-steroid anti-inflammatory drugs (NSAIDs) are the compounds more frequently involved in hypersensitivity drugs reactions. Multiple NSAID–triggered urticaria and/or angioedema and anaphylaxis in patients without pre-existing chronic urticaria (MNSAID-UA) are considered the most frequent entities. The underlying mechanism pro- posed is based on the pharmacological properties of the NSAIDs. These reactions occur as a result of mast cell activation and subsequent degranulation and generation of lipid-derived mediators. These cells can be activated by IgE-dependent and IgE-independent mechanisms that share common signaling pathways. In this work, we aimed to analyze the association between single nucleotide polymorphisms (SNPs) in key genes involved in mast cell activation and MNSAID-UA. METHODS: A total of 450 patients with MNSAID-UA and 500 individuals who tolerated NSAIDs were included. Nine SNPs in 5 genes (rs290986 in SYK, rs7140 in LAT1, rs2228246 and rs753381 in PLCG1, rs2307198, rs12749354 and rs12746200 in PLA2G4A; and rs35211496 and rs1805034 in TNFRSF11A genes) were genotyped using TaqManÒ probes. RESULTS: MNSAID-UA patients were subdivided according to the type of response and significant differences were found between MNSAID-UA patients who only developed urticaria and the following SNPs: rs2228246, OR50.30 (95% CI 50.11-0.82; P50.031) rs35211496, OR52.67 (95% CI51.37-5.19; P50.0024) and rs12746200, OR50.14 (95% CI50.03- 0.59; P50.019). Nevertheless, statistically significant differences were not found in genotype frequencies of these SNPs between MNSAID-UA and tolerant. CONCLUSIONS: We found an association between non synonymous polymorphisms rs2228246 PLCG1 and rs35211496 TNFRSF11A and the non encoding SNP rs12746200, which could be involved in PLA2G4A regulation and urticaria induced by multiple NSAIDs. J ALLERGY CLIN IMMUNOL FEBRUARY 2014 AB264 Abstracts TUESDAY
AB264 Abstracts
910
Hypersensitivity Drug Reactions (HDR) In Latin America.
Similarities and Differences Between Children and Adults
Dr. Ricardo Cardona-Villa, MD1, Dr. Edgardo J. Jares, MD2,
Dr. Maximiliano G
omez3, Dr. Luis Felipe C. Ensina, MD4, Dr. Mario
Sanchez-Borges, MD, FAAAAI5, Dr. Alfredo Arias Cruz6, Dr. Carlos
Serrano7, Dr. Mabel Noemi Cuello, MD8, Ivan Cherrez9, Dr. Andrea
Zanacchi10, Prof. Alicia De Falco11, Dr. Silvana Monsell2, Dr. Adolfo
Salvatierra12, Dr. Susana Barayazarra10, Dr. Susana Diez-Zuloaga1,
Dr. Blanca Maria Morfin-Maciel, MD13, Dr. Paola Toche Pinaud14,
Dr. Sandra Gonzalez Dıaz6, Dr. Juan F. Schuhl, MD, FAAAAI15; 1Universidad de Antioquia, Medellin, Colombia, 2C.M.P. SA, Buenos Aires,
Argentina, 3Hospital San Bernardo, Salta, Argentina, 4Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, 5Clinica El Avila, 6a transversal Altamira, piso 8, consultorio 803, Caracas., Caracas, Venezuela, 6Hospital
Universitario, Monterrey, Mexico, 7Fundacion Valle del Lili, Cali,
Colombia, 8Consultorios San Juan, San Juan, Argentina, 9Respiralab - Hospital Kennedy, Guayaquil, Ecuador, 10Nuevo Hospital San Roque, Cordoba,
Argentina, 11Universidad Nacional de La Plata, La Plata, Argentina, 12Fundair, San Luis, Argentina, 13Hospital Mocel, Mexico City, Mexico, 14Clınica
Las Condes, Santiago, Chile, 15British Hospital, Montevideo, Uruguay.
RATIONALE: HDR are frequent motives for consultation in Allergology
services. Possible etiologic factors and clinical presentation differences
between Latin American children and adults have not been described yet.
METHODS: An observational cross sectional study using a modified
ENDA questionnaire was implemented in 19 allergology units in 11 LatinAmerican countries, reporting patients presenting HDR in the last year
before consultation. Causal relationship was categorized according to
WHO-UMC Causality Categories: certain, probable, possible, unlikely
and conditional.
RESULTS: 727 patients, 144 (19.8%) of them under 18 years old,
presented 732 reactions. Female gender was 71.7% in adults, and 50% in
children. Atopic history was present in 44.9 and 63.8% and a history of
previous drug reaction in 31.9 and 36.9% of adults and children,
respectively. Fourteen percent of adult, and 10.7% of children had
presented previous reactions with the same drug. The clinical picture of
the reaction in adults and children was angioedema in 47.9 and 48.6%,
urticaria in 44.5 and 41.8%, maculopapular and macular exanthema in 20.3
and 22.6 %, erythema multiforme and SJS in 3.6 and 2.7% respectively.
Certain and probable causal relationships were attributed in adults and
children to NSAIDs in 55.7 and 60.3 %, beta lactams in 11.2 and 19.8%,
non beta lactam antibiotics in 8.4 and 2.5 %, anticonvulsants in 3.2 and
1.7%, chemotherapy 0.8 and 2.5% of patients, respectively.
CONCLUSIONS: Female sex was predominant in adults but not in
children. NSAIDs and antibiotics were the drugs implicated in more than
75% of patients. Beta lactam antibiotics were more frequently involved in
children.
911
TUESDAY
Copy Number Variations In ALOX5 and PTGER1 Genes Are
Associated With Susceptibility To AERD and Mnsaid-UA
Mrs. Maria Del Carmen Plaza Seron, Bsc1, Dr. Pedro Ayuso
Parejo, PhD1, Dr. Natalia Blanca-Lopez, MD, PhD1, Dr. Inmaculada
Do~
na, MD, PhD2, Dr. Jose A. Cornejo-Garcia, PhD3, Dr. Marıa Jose
Torres, MD, PhD2, Dr. Javier Fernandez4, Dr. Jose Julio Laguna, MD,
PhD5, Veronique Godineau3, Ms. Miriam Osorio6, Mrs. Luisa
Galindo, RN2, Dr. Gabriela Canto, MD, PhD1, Dr. Miguel Blanca, MD,
PhD2; 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 2Allergy
Service, Carlos Haya Hospital, Malaga, Spain, 3Research Laboratory, Carlos Haya Hospital, Malaga, Spain, 4UMH Alicante G.University Hospital Allergy Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Madrid, Spain,
6
Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain.
RATIONALE: Aspirin-exacerbated respiratory disease (AERD) and
Multiple NSAID–triggered urticaria and/or angioedema and anaphylaxis
in patients without pre-existing chronic urticaria (MNSAID-UA) are the
main manifestations of hypersensitivity reactions. Both are mediated by a
non-specific immunological mechanism based on NSAIDs capacity to
inhibit COX-1 and evoke an unbalance of metabolic pathway of
J ALLERGY CLIN IMMUNOL
FEBRUARY 2014
arachidonic acid. Copy number variations (CNVs) are DNA segments
present at variable copy number that may affect the expression of genes and
be associated with susceptibility to diseases. The aim of this study was to
analyze association of CNV in genes implicated in arachidonic acid
pathway with MNSAID-UA and AERD.
METHODS: We studied a total of 150 patients with AERD, 310
MNSAID-UA and 315 tolerant controls. We used TaqManÒ copy number
assays to analyze CNVs in PTGS1, PTGS2, LTC4S, ALOX5 and PTGER1-4
genes. The results were analyzed using the Copy Caller Software and SPSS
11.5 program.
RESULTS: We found differences in ALOX5 and PTGER1 genes. All controls showed 2 copies of each gene analyzed. Concerning to ALOX5, we
identified 7 AERD patients (5.0%; AERD vs. Controls P< 0.001) and 13
MNSAIDS-UA patients (4.17%; MNSAID-UA vs. Controls P< 0.001)
with a single copy of this gene. Regarding to PTGER1, we identified 19
MNSAID-UA patients (6.11%; MNSAID-UA vs. Controls P< 0.0001)
with a single copy of the gene, no AERD patients showed a single copy.
CONCLUSIONS: We found statistically significant differences in CNVs
of genes ALOX5 and PTGER1 between healthy controls and MNSAID-UA
and AERD. Whether these variations imply a dysfunctional gene expression require further studies.
912
Association Study Of Genes Involved In Mast Cell Activation
and Mnsaid-UA
Dr. Pedro Ayuso Parejo, PhD1, Mrs. Maria del Carmen PlazaSeron, Bsc1, Dr. Inmaculada Do~na, MD, PhD2, Dr. Natalia BlancaLopez, MD, PhD1, Dr. Jose A. Cornejo-Garcia, PhD3, Dr. Maria J.
Torres, MD, PhD2, Dr. Javier Fernandez4, Dr. Jose Julio Laguna, MD,
PhD5, Ms. Miriam Osorio6, Veronique Godineau3, Mrs. Luisa
Galindo, RN2, Dr. Cristobalina Mayorga, PhD3, Dr. Gabriela
Canto, MD, PhD1, Dr. Miguel Blanca, MD, PhD2; 1Allergy Service,
Infanta Leonor Hospital, Madrid, Spain, 2Allergy Service, Carlos Haya
Hospital, Malaga, Spain, 3Research Laboratory, Carlos Haya Hospital,
Malaga, Spain, 4UMH Alicante G.University Hospital - Allergy Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Madrid, Spain, 6Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain.
RATIONALE: Non-steroid anti-inflammatory drugs (NSAIDs) are the
compounds more frequently involved in hypersensitivity drugs reactions.
Multiple NSAID–triggered urticaria and/or angioedema and anaphylaxis
in patients without pre-existing chronic urticaria (MNSAID-UA) are
considered the most frequent entities. The underlying mechanism proposed is based on the pharmacological properties of the NSAIDs. These
reactions occur as a result of mast cell activation and subsequent
degranulation and generation of lipid-derived mediators. These cells can
be activated by IgE-dependent and IgE-independent mechanisms that
share common signaling pathways. In this work, we aimed to analyze the
association between single nucleotide polymorphisms (SNPs) in key genes
involved in mast cell activation and MNSAID-UA.
METHODS: A total of 450 patients with MNSAID-UA and 500
individuals who tolerated NSAIDs were included. Nine SNPs in 5 genes
(rs290986 in SYK, rs7140 in LAT1, rs2228246 and rs753381 in PLCG1,
rs2307198, rs12749354 and rs12746200 in PLA2G4A; and rs35211496
and rs1805034 in TNFRSF11A genes) were genotyped using TaqManÒ
probes.
RESULTS: MNSAID-UA patients were subdivided according to the type
of response and significant differences were found between MNSAID-UA
patients who only developed urticaria and the following SNPs: rs2228246,
OR50.30 (95% CI 50.11-0.82; P50.031) rs35211496, OR52.67 (95%
CI51.37-5.19; P50.0024) and rs12746200, OR50.14 (95% CI50.030.59; P50.019). Nevertheless, statistically significant differences were
not found in genotype frequencies of these SNPs between MNSAID-UA
and tolerant.
CONCLUSIONS: We found an association between non synonymous
polymorphisms rs2228246 PLCG1 and rs35211496 TNFRSF11A and the
non encoding SNP rs12746200, which could be involved in PLA2G4A
regulation and urticaria induced by multiple NSAIDs.
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The Romanian and Bulgarian languages share common features stemming from the Balkan linguistic aria. Among the distinctive grammatical constructions in Balkan languages is the new-type analytic subjunctive, a replacement for the infinitive in various languages such as Romanian, Bulgarian, Macedonian, Albanian, and Greek. The subjunctive can manifest in present, imperfect, perfect, and pluperfect tenses in most languages. However, Romanian has more limited combinations, employing only the present and perfect tenses. Despite these differences, the subjunctive shares structural, semantic, and usage similarities across Balkan languages. The use of the subjunctive in optative sentences is a common feature in Balkan languages, conveying achievable desires in the present and strong but unrealizable wishes in the past. This paper aims to broaden the research on the Balkan-type subjunctive by illustrating parallels in the modal values of this mood in Romanian and Bulgarian in independent optative sentences. The research underscores numerous correspondences in the use of the subjunctive in optative sentences in Romanian and Bulgarian. In both languages, within the optative context, the subjunctive expresses various sentiments such as desire, wishes, regret, protest, and indignation. The expression of both factual and counterfactual desires using present and past subjunctive forms is also similar in both languages. The present forms of the subjunctive express a factual desire, meaning an achievable wish that could be fulfilled in the future. The present subjunctive forms are very often encountered in idiomatic expressions that convey wishes and imprecations. Many similarities are noted between expressions in the two languages, both in terms of structure and in semantics and lexical means. The use of present subjunctive forms is not typical for expressing counterfactual wishes (unrealizable or difficult to achieve) but occurs in specific contexts. Wishes expressed through past subjunctive forms are counterfactual because the circumstances in which they could have been realized are omitted. Such statements convey the speaker's regret regarding an unfulfilled desire. In Romanian grammar, detailed treatment of the uses of the perfect subjunctive is lacking, but it is noted to have optative value. In Bulgarian, counterfactual wishes are expressed using three past tenses of the subjunctive – pluperfect, imperfect, and perfect. In this regard, the capabilities of the perfect subjunctive in Romanian stand out for expressing multiple meanings. With the exception of some meanings of the imperfect subjunctive in Bulgarian, the perfect subjunctive in Romanian can convey nearly all the meanings of the three past tenses in Bulgarian. The study highlights numerous similarities in the use of the subjunctive in Romanian and Bulgarian in optative sentences, offering observations that contribute to a deeper understanding of this mood within the field of Romanian, Bulgarian, and Balkan linguistics.
The article presents a codicological study of the three ancient Ethiopian Gospels of Abba Garima. The author rearranges the sequence of the disordered folios of the manuscripts in detailed tables, proposes a new foliation system and proceeds to catalogue-like descriptions. Attentive inspection of each folio led to the discovery of original quire numbers as well as original and later liturgical annotations put in folio margins, among which there are liturgical rubrics in rare unvocalized consonantal script. Detailed tables of Gospel pericopes and of dates of their liturgical use accompany the descriptions, as well as a discussion of the lectionary system and of the liturgical terminology as attested by the rubrics. The author also discusses philological characteristics of the two subsidiary texts originally included in the Abba Garima manuscripts, ‘Discourse on the Harmony of Gospels’ and ‘Letter of Carpianus’ of Eusebius of Caesarea. The article contains an edition, an English translation and a succint historical commentary of three hitherto inedited donation notes from the 15th-16th centuries.
Teachers play an essential role in the early detection and treatment of students with specific learning disabilities, hence the interest in assessing their knowledge and attitude towards this group of students. The aims of the current study were: to analyze differences in knowledge about specific learning disabilities of teachers from different educational profiles (Elementary Schools and Middle School teachers) and of teachers with different levels of experience with students with specific learning disabilities; and to examine teacher's causal attributions of students with and without specific learning disabilities. Participants were 237 teachers, of whom 78.1% were women. Of the total 118 were elementary school teachers and 119 middle school teachers. All of them filled out the scale of knowledge about specific learning disabilities in Reading (38 items) which includes three dimensions (General Information, Symptoms/Diagnosis, Treatment) and the questionnaire of teachers' casual attributions for students' achievement (four items). Middle school teachers and teachers with lack experience with specific learning disabilities students displayed lower levels of knowledge of specific learning disabilities. Teachers substantially attribute students' (with and without specific learning disabilities) achievement to intrinsic factors. In the case of failure, teacher's causal attributions to external factors increased with specific learning disabilities students.
Increasing attention is paid to sustainability in conservation. Among all the kinds of objects those ones made of paper (e.g. documents, books, artworks) present the important problem of their increasing brittleness due to the inherently acid nature of many modern papers; research for sustainable restoration materials and methods in this field is particularly needed. Our contribution relies in the preparation of innovative materials and in the exploitation of their effects on paper for application in restoration. A research line regards paper consolidation and we extracted and tested the polysaccharide fraction from the cyanobacterium Arthrospira maxima for this purpose. Another research approach focuses on green ionic liquids; these not-toxic compounds, which can help in cleaning operations, are synthesized and their effect on paper explored; here a cholin-glycine based one is considered. Testing was carried out on plain paper samples (pure cellulose) subjected to accelerated aging...
The paper is with a German summary, about Early Byzantine fortifications and towns in modern Southern Serbia. It shows several examples of excavated and not excavated fortifications, among them Caričin grad/Iustiniana Prima?,Bregovina, Zlata, Balajnac etc., with a look on the methods of investigation and some critical remarks. The fortresses are mainly, but not in every case, considered as fortified villages.
In almost all discussions of the future that I see, hear, or read, the central theme is the coming crisis of climate change, and, I think, that is appropriate. It is going to take a multi-national coordinated effort to preserve civilization. The only modern precedent I can think of is the allied coordination of World War II, although that scale is too small. There is no question that the planet and all the cultures on it are going to undergo dramatic unprecedented change. The only ques- tion is: what will that change be like?
In this essay I want to envision what the future might become if the worldview of humanity changed. What could life be like if the 4000-year-old Middle Eastern worldview holding that humans have dominion over the earth was abandoned? It is such a deeply incul- cated cultural artifact that it is still a factor in the third decade of the 21st century.
Gluten free food for people with celiac disease based on quinoa, rice and corn flours and starches, were formulated. An informatic tool (ALIM V 1.0) developed by the authors, was used for the formulation of these foods. The obtained products were pancakes, scons, precooked pizza and bread which were analyzed in their chemical composition (protein, fat, fiber, moisture, ash and carbohydrates). Water activity (aw), acceptability and texture parameters (hardness, gumminess, chewiness, adhesiveness and cohesiveness) were also determined. Commercial products (C) were taken as reference and were performed the same analysis to formulated products (F). Significant differences were found in protein, fat moisture, ash and fiber content and in most of the texture parameters studied in both food groups (p<0.05). In pancakes and scones (F) was observed an increase of protein of 88 and 198% respectively, while prepizza and bread (F) showed lower contents (8 and 22%) respect to their commercial...
Assistive technologies can help older people stay at home longer and more independently. Like any other user group, seniors have specific profiles and demands that are to be considered when designing such technologies. This paper presents an approach to multimodal user interface design and development based on the Model-Centered Architecture paradigm. The research is part of the Human Behavior Monitoring and Support (HBMS) project that aims at providing a comprehensive assistive system. The approach should enable assistive systems to be flexibly adapted to any user needs with regard to interaction and corresponding end
Protective textiles used for military applications must fulfill a variety of functional requirements, including durability, resistance to environmental conditions and ballistic threats, all while being comfortable and lightweight. In addition, these textiles must provide camouflage and concealment under various environmental conditions and, thus, a range of wavelengths on the electromagnetic spectrum. Similar requirements may exist for other applications, for instance hunting. With improvements in infrared sensing technology, the focus of protective textile research and development has shifted solely from providing visible camouflage to providing camouflage in the infrared (IR) region. Smart textiles, which can monitor and react to the textile wearer or environmental stimuli, have been applied to protective textiles to improve camouflage in the IR spectral range. This study presents a review of current smart textile technologies for visible and IR signature control of protective tex...
The aim of this paper is to analyse the question of a personal search for identity as well as the broader cultural concept of "feminine identity" in relation to domesticity and landscape in Deborah Levy's Real Estate, published in 2021. The third and last instalment of Levy's "A Living Autobiography" series is an account of a woman's search for identity in the context of major life changes: no longer a wife, no longer a mother living with her children, and no longer young, the narrator (who is and is not the author, according to Levy herself) examines her own relationship with home, homeland, and houses in various geographical locations, including her dream househer unreal estate. The spectral dream house, positioned at the intersection of the past, the present, and the future, together with land and a very specific type of fluid landscape, constitute an object of the narrator's profound desire. By expanding on the topic of this longing, Levy engages in reflection on women's wanting and its habitual subjugation to the needs of others. The paper demonstrates how in this way Levy enters into a dialogue with Sigmund Freud and his famous unanswered question "Was will das Weib?" Most importantly, it is shown how the narrator generally considers women's-including female artists'-place at home and in culture within patriarchy. Applying a feminist and gender studies perspective, as well as by combining hauntology with housing studies, this paper examines the key symbolism of Real Estate and ultimately reads the book as a feminist writer's manifesto declaring "my books are my real estate," while placing it against the background of older feminist tradition, represented
Journal of Investigational Allergology Clinical Immunology Official Organ of the International Association of Asthmology and Sociedad Latinoamericana De Alergia E Inmunologia, 2009