Discontinuation of HIV Pre-Exposure Prophylaxis among people in serodifferent relationships: Findings from a programmatic surveillance study within a large-scale HIV program in Nigeria

BACKGROUND: As Oral PrEP scales across countries, more information about uptake, use pattern and client preference emerge from pilots, demonstration studies and national programmes. The findings are useful for refining service provision and providing learnings on how oral PrEP and other prevention products or methods can be effectively incorporated into routine health services. Our study examines factors associated with discontinuation of PrEP across two large scale programs in Nigeria to present findings representative of real-world programmatic implementation. METHODS: Through programmatic surveillance of program implementation data from two large-scale HIV projects in Nigeria, we explored early discontinuation of PrEP and associated factors among HIV-negative individuals who initiated PrEP between January 2020 and July 2021 using multivariable logistic regression. RESULTS: Of 26,325 HIV-negative individuals who started PrEP, 84% (22,034) discontinued PrEP within the first month. ...