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2000
Specialized APC such as macrophages, B cells and especially DC have the capacity to capture, process and present in a MHC class-I restricted manner various exogenous cell associated antigens, including minor histocompatibility antigens, tumor antigens, or antigens derived from apoptotic, necrotic and/or virus-infected cells (1-4), a process referred to as cross-presentation. Cross-presentation can be extended to a wide range of
The Journal of Immunology
Leishmania Antigens Are Presented to CD8+ T Cells by a Transporter Associated with Antigen Processing-Independent Pathway In Vitro and In Vivo2006 •
Revista da Sociedade Brasileira de Medicina Tropical
CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasisInfection, Genetics and Evolution
An in silico immunological approach for prediction of CD8+ T cell epitopes of Leishmania major proteins in susceptible BALB/c and resistant C57BL/6 murine models of infectionThe Journal of experimental medicine
MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major2004 •
Control of the intracellular protozoan, Leishmania major, requires major histocompatibility complex class II (MHC II)-dependent antigen presentation and CD4+ T cell T helper cell 1 (Th1) differentiation. MHC II-positive macrophages are a primary target of infection and a crucial effector cell controlling parasite growth, yet their function as antigen-presenting cells remains controversial. Similarly, infected Langerhans cells (LCs) can prime interferon (IFN)gamma-producing Th1 CD4+ T cells, but whether they are required for Th1 responses is unknown. We explored the antigen-presenting cell requirement during primary L. major infection using a mouse model in which MHC II, I-Abeta(b), expression is restricted to CD11b+ and CD8alpha+ dendritic cells (DCs). Importantly, B cells, macrophages, and LCs are all MHC II-negative in these mice. We demonstrate that antigen presentation by these DC subsets is sufficient to control a subcutaneous L. major infection. CD4+ T cells undergo complete T...
Journal of Experimental Medicine
MHC Class II Expression Restricted to CD8 + and CD11b+ Dendritic Cells Is Sufficient for Control of Leishmania major2004 •
International Immunopharmacology
Immunoregulatory mechanisms and CD4−CD8− (double negative) T cell subpopulations in human cutaneous leishmaniasis: A balancing act between protection and pathology2008 •
Parasite Immunology
Cross-talk between CD8+ and CD4+ T cells in experimental cutaneous leishmaniasis: CD8+ T cells are required for optimal IFN-gamma production by CD4+ T cells2003 •
The Journal of Immunology
CD8+ T Cells Are Required for Primary Immunity in C57BL/6 Mice Following Low-Dose, Intradermal Challenge with Leishmania major2002 •
Journal of Investigative …
T cells specific to leishmania and other nonrelated microbial antigens can migrate to human leishmaniasis skin lesions2010 •
2000 •
T cell mediated immunity is known to play a central role in the host response to control intra-cellular pathogens. This work demonstrates the presence of specific CD4(+) T cells to Leishmania spp. antigens in peripheral mononuclear cells of naïve individuals (normal volunteers from non-endemic regions). The responder population was expanded by generation of antigen-specific T cell lines, which were produced by repeated stimulation with fixed promastigotes and autologous irradiated PBMC as antigen presenting cells. The leishmania-T cell lines were shown to proliferate in response to different species of the parasite (L. amazonensis, L. braziliensis, and L. donovani), but not to other recall antigens such as Candida albicans or tetanus toxoid. A preferential expansion of IFNgamma and IL-2 producing Th1-like T cells was observed. The leishmania-reactive cells were distributed between CD4(+) CD45RA(+) ("naïve") and CD4(+) CD45R0(+) ("memory") populations. Although limiting dilution analysis showed a precursor frequency 3 times lower within the naïve compartment, similar numbers of T cell lines were derived from both purified subpopulations. This study using leishmania-specific CD4(+) T cell lines produced from normal individuals should provide information on cellular immune responses that are triggered by the parasite and how infection impacts the naïve T cell repertoire.
School Science Review in Depth
Science education at a time of existential risk2023 •
DergiPark (Istanbul University)
Metodolojik Tabiatçılık Tartışmaları Bağlamında Gazali’nin Tabiî Nedensellik Eleştirisi2022 •
Awareness of the communicative language teaching principles by English teachers
Awareness of the communicative language teaching principles by English teachers2019 •
1999 •
IET Computer Vision
K‐means based multiple objects tracking with long‐term occlusion handling2017 •
EMPIRIA: Revista de Metodología de Ciencias Sociales
Modelización del análisis de las desigualdades en la distribución de la renta2002 •
Magna Scientia Advanced Biology and Pharmacy
Evaluation of knowledge on home management of malaria in under-fives among mothers and caregivers in Bende Local Government Area (LGA), Abia State, Nigeria2023 •
International Journal of Production Research
Performance evaluation of flexible manufacturing systems with blocking1989 •
Mankavarzhut'yan ev hogebanut'yan himnakhndirner
Neuro–Linguistic Programming in the System of Undergraduate Russian Language Teaching2013 •
Heart Lung and Circulation
Outcomes following repair of left partial anomalous pulmonary venous connection in children2015 •
2020 •
International Journal of Automotive Engineering and Technologies
An application for the selection of steel sheet materials used in automotive construction with the MOORA methodCommunications of the IBIMA
An Enterprise Architecture Methodology for Business-IT Alignment: Adopter and Developer Perspectives2011 •