Muscarinic toxin-like proteins from cobra venom

Toxicon, 1991

Annals of the New York Academy of Sciences, 1994

Biochimie, 2000

Life Sciences, 1997

FEBS Letters, 1994

Life sciences, 2011

We have isolated a new muscarinic protein (MT-Mlα) from the venom of the Brazilian coral snake Micrurus lemniscatus. This small protein, which had a molecular mass of 7,048Da, shared high sequence homology with three-finger proteins that act on cholinergic receptors. The first 12 amino acid residues of the N-terminal sequence were determined to be: Leu-Ile-Cys-Phe-Ile-Cys-Phe-Ser-Pro-Thr-Ala-His. The MT-Mlα was able to displace the [(3)H]QNB binding in the hippocampus of rats. The binding curve in competition experiments with MT-Mlα was indicative of two types of [(3)H]QNB-binding site with pK(i) values of 9.08±0.67 and 6.17±0.19, n=4, suggesting that various muscarinic acetylcholine receptor (mAChR) subtypes may be the target proteins of MT-Mlα. The MT-Mlα and the M(1) antagonist pirenzepine caused a dose-dependent block on total [(3)H]inositol phosphate accumulation induced by carbachol. The IC(50) values for MT-Mlα and pirenzepine were, respectively, 33.1 and 2.26 nM. Taken toget...

Ken Trotman Publishing, 2024

I came across the original copy of this book by Sir Charles Hotham publishinged in 1764 many years ago. At that time it cost a fortune and is undoubtedly even more valuable now. My desire to purchase it was two-fold. Firstly a fascination to have a monstrously rare early account of this vital phase of the Seven Years War that included of course the great battle of Minden, and secondly, the sheer beauty of the volume with its spectacular hand-coloured maps. Clearly the volume demanded a large format facsimile reprint. This is not just a simple crude scan like so many such volumes these days, but one that reflects the beauty of the original volume and addresses its major problem. To the rescue, as so often happens, came my very dear friend Stephen Summerfield. I know of no other person who can feel the shape of book’s narrative and who has a genius for breaking text into understandable sections to clarify the progress of events. This is hugely important, for the original volume was one vast body of unbroken text, without even chapters, contents page or index although full of valuable information. The book now reads like the campaign diary for the Army of Frederick of Brunswick, separated into three volumes. The chapters refer to months or battles with immensely detailed dated section headings. Each volume can be referred to and read with ease. Stephen is also a rather skilful scanner, although he will tell you between gritted teeth that it took him several goes through the book to get it to the state it is in this facsimile (that also included at least one page made largely illegible by an original ink stain – I challenge you to discover which page it is!). And what we know from previous works, Stephen is a genius at maps. This superb facsimile contains 106 contemporary hand-coloured maps and 63 orders of battle to make your journey through the story easier to follow, whilst retaining the joyousness of so many delightful coloured originals from the volume. This is just the stuff we want to do with our facsimiles. The price is not cheap because we wanted to provide you with a highest quality we could, to add ever greater value to the original. Stephen, fascinated with the story of the Hessen Cassell and Hanoverian troops’ progress in England, has added even more by setting the scene of the action. We do hope you are as delighted with all of this as we are.

2019

Administrasi adalah suatu kegiatan atau rangkaian kegiatan yang berupa proses pengelolaan usaha kerjasama sekelompok manusia yang tergabing dalam suatu organisasi untuk mencapai tujuan bersama yangtelah ditetapkan sebelumnya agar efektif dan efesien.Administrasi pendidikan adalah suatu proses pengintegrasian segala usaha kerja sama untuk mendayagunakan sumber-sumber personel dan material sebagai usaha untuk meningkatkan pengembangan kualitas manusia secara efektif dan efisien. Efektif dalam arti hasil yang dicapai upaya, sama dengan tujuan yang telah ditetapkan. Sedangkan efisien berhubungan dengan penggunaan sumber dana, daya, dan waktu. Sumber adalah segala sesuatu yang membantu tercapainya tujuan baik berupa tenaga, material, uang, ataupun waktu. prinsip dari administrasi pendidikan adalah mengutamakan pengelolaan tugas bidang administrasi secara efektif dan efisien serta menjalin hubungan kerja sama dengan orang-orang yang terlibat di dalam kegiatan pendidikan demi mencapai tuju...