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2013 •
Received on 12-05-2012 Accepted on 24-06-2012 Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bi-layer tablets has been developed to achieve controlled delivery of different drugs with pre defined release profiles. In the last decade interest in developing a combination of two or more API’s in a single dosage form has increased in the pharmaceutical industry, promoting patient convenience and compliance. Several pharmaceutical companies are presently developing bi-layer tablets, for a variety of reasons patent extension, therapeutic, marketing to name a few. To decrease capital investment, quite often existing but...
International Journal of Applied Pharmaceutics
PHARMACOTECHNICAL DEVELOPMENT AND OPTIMIZATION OF MULTILAYERED TABLETS: AN UPDATED INDUSTRIAL REVIEW WITH EMPHASIS ON BILAYER TABLETS2021 •
Fixed-dose combination formulations are multilayered platforms designed for solving complex medication regimens and overcoming polypharmacy problems especially in chronic diseases with geriatric patients. Multilayered tablets are considered promising avenues to combine different active pharmaceutical ingredients (APIs) for a synergic therapeutic effect, or different formulations of the same API in order to achieve a specific drug release profile. Besides, multilayered tablets can extensively help in avoiding possible interactions between different drugs, as well as optimizing each formulation individually in terms of pharmacokinetics and manufacturability. This review article discusses the most suitable materials used in the manufacturing of multilayered tablets, describes novel approaches to manufacturing improvement and process parameters, the influence of process parameters on layer adhesion, and the characterization tests of multilayered tablets.
2012 •
Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bi-layer tablets has been developed to achieve controlled delivery of different drugs with pre defined release profiles. In the last decade interest in developing a combination of two or more API’s in a single dosage form has increased in the pharmaceutical industry, promoting patient convenience and compliance. Several pharmaceutical companies are presently developing bi-layer tablets, for a variety of reasons patent extension, therapeutic, marketing to name a few. To decrease capital investment, quite often existing but modified tablet presses are used to develop a...
2014 •
The expense and complications in new drug entities have increased since last 3 decades, with concomitant recognition of the therapeutic advantages of controlled drug delivery. So focus has been given on development of sustained or controlled release drug delivery systems. Bilayer tablet is new novel of tablet for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. For promoting patient convenience and compliance pharmaceutical industries interested in developing a combination of two or more API’s in a single dosage form. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation, and to enable the development of different drug release profiles using DUREDAS technology (immediate release with extended release / both layer extended release)...
Journal of Biomedical and Pharmaceutical Research
A Review on Bilayer Tablet Technology for Multi Modal Drug DeliveryBilayer tablets are cutting-edge drug delivery technologies that enable the delivery of two medicines with various release patterns combined in a single unit. Bilayer tablets can deliver two incompatible medications in a single formulation, prolong the effect of the drug(s), and increase patient compliance. Bilayer tablets feature an active substance in one layer that is released immediately and another layer that is released later, either as a second dosage or in a prolonged release manner. The drawbacks of single-layered tablets are being overcome by the advancement of useful technology in bilayer tablets. Bilayer tablet technology requires a lot of resources, though. For each technical stage, a careful selection of excipients and manufacturing conditions is also necessary. High blood pressure patients frequently struggle or fail to control their BP with a single medication. To achieve treatment objectives, the majority of hypertension patients will require the use of two or more ...
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