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2019, International Journal of Colorectal Disease
International Journal of Colorectal Disease
To what extent is the low anterior resection syndrome (LARS) associated with quality of life as measured using the EORTC C30 and CR38 quality of life questionnaires?2019 •
2017 •
International Journal of Colorectal Disease
Perioperative radiotherapy is an independent risk factor for major LARS: a cross-sectional observational study2018 •
IntroductionRectal cancer is common with a 60% 5-year survival rate. Treatment usually involves surgery with or without neoadjuvant chemoradiotherapy or adjuvant chemotherapy. Sphincter saving curative treatment can result in debilitating changes to bowel function known as low anterior resection syndrome (LARS). There are currently no clear guidelines on the management of LARS with only limited evidence for different treatment modalities.Methods and analysisPatients who have undergone an anterior resection for rectal cancer in the last 10 years will be approached for the study. The feasibility trial will take place in four centres with a 9-month recruitment window and 12 months follow-up period. The primary objective is to assess the feasibility of recruitment to the POLARiS trial which will be achieved through assessment of recruitment, retainment and follow-up rates as well as the prevalence of major LARS.Feasibility outcomes will be analysed descriptively through the estimation o...
Scientific Reports
Long-term bowel dysfunction following low anterior resectionStudy aimed to assess long-term bowel function in patients who underwent low anterior resection for cancer five and more years ago. Patients who underwent low anterior resection for rectal cancer from 2010 to 2015 at National Cancer Institute were prospectively included in our study. They were interviewed using low anterior resection syndrome (LARS) score and Wexner questionnaire. We also assessed possible risk factors of postoperative bowel disorder. 150 patients were included in our study. Of them 125 (83.3%) were analysed. The median age at diagnosis was 62 years (40–79), and the average time of follow-up was 7.5 years (5–11). Overall, 58 (46.4%) patients had LARS, of them 33 (26.4%)—major LARS and 25 (20%)—minor LARS and 67 (53.6%) reported no LARS. Wexner score results were: normal in 43 (34.4%) patients, minor faecal incontinence—55 (44%), average faecal incontinence—18 (14.4%), complete faecal incontinence—9 (7.2%). 51 patients (40.8%) had tumour in the upper third rectum, 51...
Annals of Coloproctology
Risk factors associated with low anterior resection syndrome: a cross-sectional study2021 •
BACKGROUND: In Europe, colorectal cancer is the second most common cancer in women and third most common in men. Around half of all colorectal cancer cases affect the rectum. Surgery is the main curative therapy for rectal cancer however this is associated with bowel functional disturbances post anterior resection. The wide spectrum of symptoms following resection and restitution of rectum is what constitutes anterior resection syndrome.METHODS: Adult patients who had undergone anterior resection between January 2014 and December 2016 were recruited. Variable factors for LARS were collected retrospectively from clinical records. Data was collected using validated questionnaires, namely LARS scale and EORTC QLQ-C30. Statistical analysis included ordinal logistic regression, one-way ANOVA and Scheffe post-hoc test.RESULTS: Between January 2014 and December 2016, 179 patients had undergone anterior resection, with 55 patients fulfilling the inclusion criteria. Symptoms of LARS were ide...
Caspian Journal of Internal Medicine
Inter sphincter rectal resection with and without Malone ante grade continence enema in cases with low rectal cancer: A randomized, prospective, single-blind, clinical trialBackground: Fecal incontinence is the main morbidity of inter-sphincteric resection (ISR) in ultra-low rectal cancer. Malone Ante grade Continence Enema (MACE) has been proposed for these patients. We aimed to compare the quality of life outcomes in cases with ultra-low rectal cancer who had undergone ISR±MACE. Methods: The current randomized clinical study was accomplished for two years from December 2016 to February 2018 in Imam Khomeini Hospital (Sari City, I.R.Iran) on 30 patients (15 in each group) with rectal cancer. The inclusion criteria of the study were stage 1 and 2a of low rectal cancer with type 2 and 3 of Rullier's classification, those who received neoadjuvant chemo radiotherapy. The exclusion criteria were comorbidity diseases, immune deficiency, poor follow-up. The follow-up period was one year. The Quality of Life (Qol) was reported as primary endpoint. The EORTC QLQ-C30 score and Wexner questionnaires were used. SPSS Version 22 was used. A p-value less than 0.05 was considered statistically significant. Results: The mean age of patients was 56.23±8.72 years. The overall Qol score was better in the ISR-MACE (P=0.023). The overall Qol was lower in women than in men in both groups. Low anterior resection syndrome score was lower in the ISR plus MACE group than the ISR group (P=0.030). The Wexner score revealed better scores in the ISR with MACE group than the ISR without MACE group (p<0.0001). Conclusion: Patients who underwent ISR plus MACE surgery had better defecation control and better quality of life than patients without MACE.
Diseases of the Colon & Rectum
Mechanism of sphincter impairment following low anterior resection1992 •
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