1135 Scientific Abstracts spine via antero-posterior (AP) and lateral projections, neck of femur (NOF) and total hip were measured. Results: Low BMD was found in half of the 92 Chinese AS patients. Factors associated with low BMD were BASDAI, BASMI, post-menopausal status, body mass index (BMI), alcohol use and family history of AS. Multiple logistic regression analysis by backward selection revealed that BASDAI (odds ratio (OR) 1.03, 95% confidence interval (CI)1.00–1.06; p =0.031), post-menopausal status (OR 6.11, 95% CI 1.07–34.81; p =0.041), BMI (OR 0.81, 95% CI 0.71–0.93; p =0.003) and alcohol use (OR 4.79, 95% CI 1.49–15.38; p =0.008) were significantly associated with low BMD. Total hip BMD was more sensitive than AP lumbar BMD in detecting low BMD in AS. Conclusions: Low BMD in AS is not uncommon and often underdiagnosed. BASDAI, post-menopausal status, alcohol use and BMI were independently associated with low BMD in this study. References: [1] El Magharaoui A. Osteoporosis and ankylosing spondylitis. Joint Bone Spine 2003;71:291–295 [2] Roux C. Osteoporosis in inflammatory joint diseases. Osteoporos Int 2011;22:421–433 [3] Vosse D, Landewe R, van der Heijde D, van der Linden S, van Staa T-P, Geusens P. Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control study. Ann Rheum dis 2009;68:1839–1842 [4] Ghozlani I, Ghazi M, Nouijai A, Mounach A, Rezqi A, Achemlal L, Bezza A, El Maghraoui. Prevalence and risk factors of osteoporosis and vertebral fractures in patients with ankylosing spondylitis. Bone 2009;44:772–776 Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2016-eular.4163 AB0673 ARTERIAL STIFFNESS, DISEASE ACTIVITY AND FUNCTIONAL IMPAIRMENT IN ANKYLOSING SPONDYLITIS PATIENTS C. Avram 1 , R.G. Dragoi 2 , E. Amaricai 2 , M. Dragoi 2 . 1 Department of Physical Therapy and Special Motricity, West University of Timisoara; 2 Department of Rehabilitation, Physical Medicine and Rheumatology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Background: Cardiovascular risk is an important factor for increased morbidity and mortality in patients with ankylosing spondylitis. Currently, it is estimated that the cardiovascular risk from atherosclerotic origin in patients with ankylosing spondylitis is twice as high compared with aged-matched controls [1–4]. Arterial stiffness appears to contribute to the complex aetiology of cardiovascular disease and is regarded as a predictor of increased cardiovascular risk and all-cause mortality [5]. Objectives: To assess arterial stiffness in relation to the disease activity and functional limitation in patients with ankylosing spondylitis. Methods: Twenty four patients (mean age: 45.8±11.7 years) suffering of ankylosing spondylitis (disease duration: 11.1±5.1 years) and twenty four gender and age-matched healthy controls were included in the study. Clinical, biological and functional status of ankylosing spondylitis patients was recorded. Arterial stiffness was assessed by measuring pulse wave velocity (PWV) and pulse wave analysis was performed using applanation tonometry. Results: We found significant differences between ankylosing spondylitis patients and healthy controls in regard to PWV (p=0.047), aortic augmentation pressure - AP (p=0.028), augmentation index - AIx (p=0.038) and aortic augmentation index adjusted for heart rate - AIx75 (p=0.011). PWV and AIx75 were significantly associated with the disease functioning score - BASFI (p=0.012, r =0.504; p=0.041, r=0.421). Aortic AP and augmentation indexes (AIx and AIx75) were all associated to ASDAS score (p=0.028, r=0.448; p=0.005, r=0.549; p=0.025, r=0.455). Conclusions: Our study showed that ankylosing spondylitis patients have a higher arterial stiffness than the age-matched controls, leading to an increased cardiovascular risk. We found that arterial stiffness is positively associated with disease activity and functional impairment. Chronic spondiloarthropaties should be screened for arterial stiffness, even in the absence of traditional cardiovascular risk factors, in order to benefit from primary prevention measures. References: [1] Sveaas SH, Berg IJ, Provan SA, et al. Efficacy of high intensity exercise on disease activity and cardiovascular risk in active axial spondyloarthritis: a randomized controlled pilot study. PLoS One. 2014 Sep 30;9(9):e108688. [2] Mathieu S, Gossec L, Dougados M, et al. Cardiovascular profile in ankylosing spondylitis: a systematic review and meta-analysis. Arthritis Care Res. 2011;63:557–563. [3] Bremander A, Petersson IF, Bergman S, et al. Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis. Arthritis Care Res. 2011;63:550–556. [4] Bakland G, Gran JT, Nossent JC. Increased mortality in ankylosing spondylitis is related to disease activity. Ann Rheum Dis. 2011;70:1921–1925. [5] Laurent S, Boutouyrie P. Arterial stiffness: a new surrogate end point for cardiovascular disease? J Nephrol. 2007;12:S45–50. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2016-eular.2533 AB0674 SECRETORY IGA: NEGATIVE CORRELATION WITH DISEASE ACTIVITY MEASURES IN HLA B27 POSITIVE SPONDYLOARTHRITIS PATIENTS C. Romero-Sanchez 1 , F. Salas-Cuestas 2 , J. Bello 1 , I. Arias 3 , W. Bautista-Molano 2 , V. Parra I 4 , D. Herrera 3 , R. Valle-OÑAte 1 . 1 Rheumatology Department, Hospital Militar Central; 2 School of Medicine, Universidad Militar Nueva Granada; 3 Instituto de Genética Humana, School of Medicine, Pontificia Universidad Javeriana; 4 School of Medicine, Universidad de la Sabana, Bogota, Colombia Background: The human Major Histocompatibility Complex (MHC) encompasses a group of genes located in chromosome 6 (6p21.3); it encodes proteins expressed on the cell surface. The HLA-B27 is a MHC class I molecule associated with spondyloarthritis (SpA); many theories related to its natural function have been postulated to explain its pathogenic role.(1–2) Relevance of HLA-B27 molecule in the mucosal immune system, the gut mucosa inflammation, and secretory IgA (SIgA) production remains unresolved. Objectives: The purpose of this study was to evaluate the correlation between serum SIgA levels and disease clinical activity in a cohort of HLA B27 positive and negative SpA patients with ReA and USpA, in a clinical center in Bogota Colombia. Methods: The concentration of SIgA in serum was measured by an enzyme linked immunosorbent assay and the HLA-B27 was assessed by flow cytometry, followed by Polymerase Chain Reaction with sequence specific primers, in 46 patients with USpA and ReA. Clinical gastrointestinal manifestations and activity indices (BASDAI, ASDAS x CRP and ASDAS x ESR) were collected from each patient. Statistical analysis was performed using Stata 11.2 ® software for Windows; Pearson correlation was used to measure the degree of relationship between SIgA and clinical activity depending on the HLA B27 status. The study was approved by local hospital’s ethics committee. Results: 46 SpA patients completed the study with mean age of 34,8 ±12,3 years; 78,2% were men, 52,17% were HLA B27 positive, 60.9% of patients reported gastrointestinal symptoms such as diarrhea, abdominal pain, abdominal swelling and hematochezia. 63,6%, 88,6% and 100% of patients had disease activity evaluated by BASDAI, ASDAS-CRP and ASDAS-ESR scores, respectively, and 71,7% of patients had SIgA concentration above the upper normal range. The SIgA concentration was correlated with disease activity measures: BASDAI, ASDAS-CRP and ASDAS-ESR (-42% (0.0046), -37% (0.014) and -45% (0.0021) respectively); the negative coefficient correlation between SIgA and BASDAI, ASDAS-CRP and ASDAS-ESR was higher in HLA-B27 + patients -70% (0.0009), -58% (0.0093) and -57% (0.0083) than in HLA-B27 – patients. Correlation HLA-B27 positive SIgA vs BASDAI SIgA vs ASDAS-CRP SIgA vs ASDAS-ERS HLA-B27 negative Pearson Coefficient P value Pearson Coefficient P value −70% −58% −57% 0.0009 0.0093 0.0083 −21% −20% −35% 0.3397 0.3579 0.0992 Conclusions: These results suggest that SIgA levels in patients with ReA and USpA might be a correlate of disease activity measures based upon HLA-B27 status and might reflect an immunomodulatory role in these pathologies. References: [1] Bowness P. HLA-B27. Annu Rev Immunol. 2015; 33:29–48. [2] Chatzikyriakidou A, Voulgari PV, Drosos AA. What is the role of HLA-B27 in spondyloarthropathies? Autoimmun Rev. 2011 Jun; 10(8):464–8. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2016-eular.4976 AB0675 IS THE PERIODONTAL CLINICAL AND MICROBIOLOGICAL CONDITION IN SPONDYLOARTHRITIS SIMILAR THAN RHEUMATOID ARTHRITIS? S. Giraldo Q 1 , C. Romero-sanchez 1,2,3 , W. Bautista-Molano 1 , J.M. Bello-Gualtero 1 , J. De-Avila 2 , L. Chila M 2 , D.M. Castillo 2 , G.I. Lafaurie 2 , J. Londoño 3 , R. Valle-Oñate 1,3 . 1 School of Medicine, Universidad Militar Nueva Granada; 2 Unit of Oral Basic Investigation, Universidad El Bosque; 3 Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central/Universidad de la Sabana, Bogotá, Colombia Background: The periodontal disease (PD) generates systemic impact given the increase in acute phase reactants related to the inflammatory. The relationship between Rheumatoid arthritis (RA) and PD is supported by pathological and immunological data but is not clear this association in Spondyloarthitis (SpA). The association between their respective disease activities and severities are less documented. Periodontal inflammation may affect disease activity and severity on patients with SpA. Objectives: To evaluate the association between clinical indices of PD and markers of disease activity in SpA patients and compare these markers in patients with RA and controls. Methods: The rheumatologic condition and periodontal status of 79 individuals with SpA, 59 patients with RA and 79 matched-controls were evaluated. Porphyromona gingivalis (Pg), IgG1, and IgG2 to Pg were determined. The C-reactive protein-, erythrocyte sedimentation rate-, HLA B 27, rheumatoid factor-