POTENTIAL DISCRIMINANT FACTORS
FOR DIFFERENT PCOS PHENOTYPES
Stojković M., Beleslin B., Ćirić J., Savić S., Nišić T., Lalić T., Stojanović M., Trbojević B. Žarković M.
Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation
(ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries
(PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1
(ANOV +HA + PCO), phenotype 2 (ANOV + HA), phenotype 3 (HA + PCO) and phenotype 4
(ANOV + PCO). The differences between these four phenotypes are still undefined and the subjects of
study.
Methods: We evaluate 92 PCOS women using stepwise linear discriminant analysis with phenotype
as dependent variable and BMI, FSH, LH, LTH, oestradiol, testosterone, progesterone, HDLcholesterol, LDL-cholesterol, HOMA IR and HOMA B as independent variables.
Results: The phenotype 1 was present in 32.6%, phenotype 2 in 21%, phenotype 3 in 28% and
phenotype 4 in 14.1 % of cases. We found that BMI, LH, HOMA IR and HOMA B were
discriminante factors for different PCOS phenotypes, while the other variables didn`t reach statistically
significant difference.
BMI
LH
HOMA IR
HOMA B
ANOV+PCO+HA
27.1±6.0 kg/m2;
7.33±4.69 IU/L;
1.49±0.34;
371.8±391.7;
ANOV+HA
29.2±8.0 kg/m2;
5.30±3.81 IU/L;
1.32±0.39;
423.1±213.1;
ANOV+PCO
22.8±4.4 kg/m2;
11.13±6.13 IU/L;
1.18±0.28;
535.1±365.5;
PCO+HA
24.9±5.8 kg/m2;
4.12 ±2.62 IU/L;
1.40±0.49;
755.6±1436.2;
Conclusions: We concluded that LH, BMI, HOMA IR and HOMA B
discriminant factors in different PCOS phenotypes.
could be useful as
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