Cancer Gene Therapy
19 Followers
Recent papers in Cancer Gene Therapy
The approval of cancer drugs by the United States Food and Drug Administration have increased progressively over the past two decades with a trend towards the adoption of targeted drugs which are more precise in their mechanisms of... more
Although mortality from colorectal cancer (CRC) is decreasing, CRC is still the second highest cause of cancer-related deaths in America. Chemotherapy and radiation therapy now have central roles in our strategies to fight cancer,... more
We have previously shown that herpes simplex virus type 1 (HSV-1) infection is associated with early destabilization/degradation of infected cell mRNAs and consequent shutoff of host protein synthesis by the activity of the... more
A herpes simplex thymidine kinase – green fluorescent protein (TK-GFP) fusion gene was constructed to couple a marker gene to a therapeutic gene. For testing the utility of the fusion gene, it was cloned into four different viral... more
Noninvasive imaging in lung metastatic tumor models is used infrequently because of technical limitations in detecting metastases. We have previously used 2'-fluoro-2'-deoxy-5-iodo-1-beta-d-arabinofuranosyluracil labeled with... more
Enhanced tumor delivery of plasmid DNA with electric pulses in vivo has been confirmed in many preclinical models. Intratumor electrotransfer of plasmids encoding therapeutic molecules has reached Phase II clinical trials. In multiple... more