Clinical and Experimental Hypnosis

1Cyclosporine A (CsA) is the first-line immunosuppressant used for the management of solid organ transplantation and autoimmune diseases. Nephrotoxicity is the major limitation of CsA use. Recent evidence suggests that reactive oxygen species (ROS) play an important role in mediating CsA-induced hypertension and nephrotoxicity. Taurine, the major intracellular free β-amino acid, is known to be an endogenous anti-oxidant and membrane-stabilizing agent. The present study was designed to investigate the effects of taurine on CsA-induced oxidative stress, hypertension and renal dysfunction.2Animals were assigned into four groups of seven rats each as follows: (i) control group, receiving vehicle (olive oil; 1 mL/kg, s.c.); (ii) CsA group, given CsA (25 mg/kg per day, s.c.) for 21 days; (iii) taurine group, supplemented with taurine (1% in the drinking water); and (iv) taurine + CsA group, treated with taurine 3 days before and concurrently during CsA injections for 21 days.3Cyclosporine A administration elevated blood pressure, reduced serum nitric oxide (NO) levels and deteriorated renal function, as assessed by increased serum creatinine levels and proteinuria and reduced urine flow rate and creatinine clearance compared with vehicle-treated rats. Cyclosporine A induced oxidative stress, as indicated by increased renal tissue concentrations of thiobarbituric acid-reactive substances and reduced concentrations of renal glutathione, glutathione peroxidase and superoxide dismutase. Conversely, no change was noted in renal catalase activity. Moreover, the kidneys of CsA-treated rats showed interstitial inflammation and renal tubular atrophy.4Taurine markedly reduced elevated blood pressure, attenuated renal dysfunction and the reduction in serum NO levels and counteracted the deleterious effects of CsA on oxidative stress markers. Furthermore, taurine ameliorated CsA-induced morphological changes.5These data clearly indicate the protective potential of taurine against CsA-induced hypertension and nephrotoxicity and suggest a significant contribution of its anti-oxidant property to this beneficial effect.Cyclosporine A (CsA) is the first-line immunosuppressant used for the management of solid organ transplantation and autoimmune diseases. Nephrotoxicity is the major limitation of CsA use. Recent evidence suggests that reactive oxygen species (ROS) play an important role in mediating CsA-induced hypertension and nephrotoxicity. Taurine, the major intracellular free β-amino acid, is known to be an endogenous anti-oxidant and membrane-stabilizing agent. The present study was designed to investigate the effects of taurine on CsA-induced oxidative stress, hypertension and renal dysfunction.Animals were assigned into four groups of seven rats each as follows: (i) control group, receiving vehicle (olive oil; 1 mL/kg, s.c.); (ii) CsA group, given CsA (25 mg/kg per day, s.c.) for 21 days; (iii) taurine group, supplemented with taurine (1% in the drinking water); and (iv) taurine + CsA group, treated with taurine 3 days before and concurrently during CsA injections for 21 days.Cyclosporine A administration elevated blood pressure, reduced serum nitric oxide (NO) levels and deteriorated renal function, as assessed by increased serum creatinine levels and proteinuria and reduced urine flow rate and creatinine clearance compared with vehicle-treated rats. Cyclosporine A induced oxidative stress, as indicated by increased renal tissue concentrations of thiobarbituric acid-reactive substances and reduced concentrations of renal glutathione, glutathione peroxidase and superoxide dismutase. Conversely, no change was noted in renal catalase activity. Moreover, the kidneys of CsA-treated rats showed interstitial inflammation and renal tubular atrophy.Taurine markedly reduced elevated blood pressure, attenuated renal dysfunction and the reduction in serum NO levels and counteracted the deleterious effects of CsA on oxidative stress markers. Furthermore, taurine ameliorated CsA-induced morphological changes.These data clearly indicate the protective potential of taurine against CsA-induced hypertension and nephrotoxicity and suggest a significant contribution of its anti-oxidant property to this beneficial effect.

The natriuretic peptide family consists of three endogenous ligands; atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and is involved in the regulation of cardiovascular homeostasis. Both ANP and BNP act mainly as cardiac hormones and are produced predominantly by the atrium and ventricle, respectively. Expression of the BNP and ANP genes is greatly augmented in patients with congestive heart failure and animal models of ventricular hypertrophy or cardiomyopathy. In the heart, the BNP gene expression is regulated differently from the ANP gene expression both at transcriptional and post-transcriptional levels. Transgenic technology has provided the direct evidence that BNP as well as ANP is involved in the chronic blood pressure control. Contrasting with ANP and BNP, CNP does not act as a cardiac hormone but as a neuropeptide or an endothelium-derived autocrine/paracrine regulator. Endothelial production of CNP is remarkably augmented by various cytokines and growth factors such as transforming growth factor-beta and tumour necrosis factor-alpha, suggesting the pathophysiological significance of CNP in the process of various vascular disorders. Chromosomal mapping of natriuretic peptides has revealed that the CNP gene is localized on mouse chromosome 1, while ANP and BNP are tightly linked on mouse chromosome 4, suggesting that CNP, a local regulator, is functionally and evolutionarily distinct from ANP and BNP, both of which are cardiac hormones. Understanding the molecular biology and biochemistry of the natriuretic peptide family will lead to the better understanding of its physiological and pathophysiological implication, and the clinical application in cardiorenal regulation.

Special issue of "Culture Unbound". Through an introduction and six original articles, the issue investigates a variety of cultural and scientific discourses and practices that in different ways are related to neuroscience and the brain.

The special issue was edited by guest editors Peter Bengtsen and Kristofer Hansson.

Suggestion is a part of communication that cannot be stripped from or be considered separate from verbal and nonverbal communication.  It is through the need to view the communication processes from a complete understanding that this study investigated the possible influence that suggestion may have on an individual’s perception of reality. The existing literature was reviewed with various results from different researchers, however, much of the literature supported previous research done by Spanos et al. (1984) and Bartels et al. (2006).
Their research showed some indications that suggestion, and possibly priming may have an influence on an individual’s perception.  Using their research as a starting point this study developed a mixed-method approach in order to test some aspects of their research.  Ten volunteers participated in a mixed-methods experiment.  A Factorial Design of 2 x 2 enabled a testing of two treatments at the same time.  The participants were tested for level of suggestibility using the Stanford Scale and were then divided into one of four groups.  Groups consisted of high or low suggestible participants who were treated with a suggestion or priming words to determine their level of discomfort when their arm was placed in ice water.  The results were measured on a scale from one to ten. 
The ANOVA showed no statistical difference in the groups.  However, the number of individuals who were unable to complete the testing was all in the high suggestibility group and it appeared that individuals in the priming group, both high and low suggestible, had the greatest reduction in discomfort relative to their baseline.


Keywords: priming, suggestion, perception, reality, ice water, suggestibility, Spanos, Bartels

ObjectiveTo describe the hangover phenomenon and briefly review its main explanatory factors.To describe the hangover phenomenon and briefly review its main explanatory factors.DesignBibliographic research on main databases (Medline and Psychinfo).Bibliographic research on main databases (Medline and Psychinfo).ResultsAlcohol hangover is characterized by adverse physical and mental effects that occur the next morning after the intake of toxic doses of alcohol. This phenomenon is a very frequent experience among alcohol-consuming people and it has been associated to high socio-economic costs, mainly due to absenteeism and poor performance in academic and work settings. Multiple theories exist to explain the appearance and severity of hangover, such as direct or indirect effects of alcohol, alcohol withdrawal, and toxic effects of alcoholic beverage congeners or of alcohol metabolites. In addition, a number of intervening factors have been identified, such as vulnerability to alcohol dependence or psychological factors.Alcohol hangover is characterized by adverse physical and mental effects that occur the next morning after the intake of toxic doses of alcohol. This phenomenon is a very frequent experience among alcohol-consuming people and it has been associated to high socio-economic costs, mainly due to absenteeism and poor performance in academic and work settings. Multiple theories exist to explain the appearance and severity of hangover, such as direct or indirect effects of alcohol, alcohol withdrawal, and toxic effects of alcoholic beverage congeners or of alcohol metabolites. In addition, a number of intervening factors have been identified, such as vulnerability to alcohol dependence or psychological factors.ConclusionsAlthough several studies analyze and describe hangover, it is still poorly understood. Further well-designed studies with a unitary methodology and clear operational criteria to define hangover are necessary in order to clarify such a phenomenon. We suggest some future working ideas that should be pursued in order to address the current shortcomings. Copyright © 2009 John Wiley & Sons, Ltd.Although several studies analyze and describe hangover, it is still poorly understood. Further well-designed studies with a unitary methodology and clear operational criteria to define hangover are necessary in order to clarify such a phenomenon. We suggest some future working ideas that should be pursued in order to address the current shortcomings. Copyright © 2009 John Wiley & Sons, Ltd.

En Belgique, la jurisprudence autorise l’utilisation de l’hypnose avec les témoins et les victimes volontaires dans les enquêtes judiciaires. Cette méthode n’est pas une technique d’enquête à proprement parler ; elle est davantage à considérer comme un complément aux méthodes d’audition classiques. Elle reste toutefois une pratique mineure réservée aux faits graves tels que meurtres, attaques de banque, viols, traite des êtres humains, etc. lorsque les indices à disposition des enquêteurs sont insuffisants à faire émerger la vérité. Bien que controversée, la méthode a prouvé son efficacité dans de nombreux dossiers. En effet, dans 60% des cas, elle permet de récupérer de nouvelles informations utiles à la progression de l’enquête.

This is a preview of the book Ainslie Meares on Meditation by Owen Bruhn.
The book includes a
- biography of Meares,
- a distilled version of Relief Without Drugs by Ainslie Meares,
- his later refined meditation method,
- his personal and teaching protocols,
- 33 samples of his koan like poetry from all 11 poetry books.
- 200 footnoted references from Meares 34 books and hundreds of articles.

Myths or misconceptions concerning hypnosis are regarded among the major barriers to effective implementation of hypnosis. Contemporary hypnotherapists are expected to elicit patients' misconceptions and to provide explanations that distinguish between mystical and scientific perceptions of hypnosis and that offer a picture of the state of the art of hypnosis. Dealing with misconceptions on a rational and cognitive level seems to have the ability to change a patient's conscious knowledge and understanding of hypnosis. Nevertheless, deeply rooted and emotionally saturated misbeliefs with historical-cultural origins still prevail. This article focuses on the prehypnotic phase of therapy and proposes remythification to deal with the myth of hypnosis. This approach aims to promote the hypnotherapeutic process by utilizing myth-related misconceptions.

[AMAZON LINK BELOW TO BOOK ITSELF -- TOC and book intro in downloadable .pdf] 
Once thought pure entertainment akin to magic acts, hypnosis is now a growing field being practiced by psychologists, psychiatrists, and medical doctors. Across all ages—from children to adults and the elderly—patients are finding professional, therapeutic hypnosis can help them recover from mental maladies ranging from addiction to depression and psychosis, and from physical illnesses from chronic pain to obesity and skin disorders. Studies show hypnosis can even speed healing from broken bones, burns, and surgery. These unprecedented volumes, including some of the best-known experts in the field hailing from Harvard, Stanford and other top universities, cover the newest research and practice in this intriguing arena. Edited by a psychologist at Harvard Medical School, this set explains developments in hypnosis, from its colorful if misguided inception with Anton Mesmer, across clinical techniques developed for health care in the 20th century, to emerging research showing new potential applications to aide mental and physical health. Chapters also highlight what psychologists, neurologists, physicians, and scientists have discovered about how personality, cognition, and brain functions affect, and are affected by, hypnosis. An appendix explains how to tell the difference between an entertainer or charlatan and a practitioner who is trained, credentialed, and practicing research-backed hypnosis. Universities with hypnotherapy programs and courses are also included.

Tourette’s syndrome is characterised by involuntary tics, repetitive movements and vocalisations and can lead to significant disturbance when engaging in daily activities.

Clinical neurofeedback is based on the concept of the neuroplasticity and the mechanism ofaction is operant conditioning. Clinical neurofeedback has been found to be effective in improving brain function.

Clinical hypnotherapy is said to deal with the unconscious processes of the mind and can be used to help treat a variety of disorders. In this case study, with a client diagnosed with Tourette’s syndrome, intervention included a combination of clinical neurofeedback and hypnotherapy.

This combination of interventions led to a significant improvement in the client’s condition over time. Future studies might make more use of psychological testing to understand client’s progress and also include long term follow up

Modern cataract surgery is safe in more than 95 per cent of patients. In the small number of cases where a serious complication occurs, the most common is an intra-operative posterior capsular rupture. This can lead to vitreous loss or a dropped nucleus and can increase the risk of post-operative cystoid macular oedema or retinal detachment. Post-operatively, posterior capsular opacification is the most common complication and can be readily treated with a YAG capsulotomy. The most devastating complication is endophthalmitis, the rate of which is now significantly decreased through the use of intracameral antibiotics. As a clinician, the most important step is to assess the patient pre-operatively to predict higher risk individuals and to counsel them appropriately. In these patients, various pre- or intra-operative management steps can be taken in addition to routine phacoemulsification to optimise their visual outcome.

Texto que permite al medico incorporar hipnosis clínica en su practica.
Es la compilación de escritos del autor principal a través de varios años.
Incluye incluso una propuesta de inducción de hipnosis aunque preferimos que el lector tome un curso serio.
  Se citan bibliografías pertinentes. Algunos artículos citan ejemplos clínicos reales.

Resumen: Describimos los principios mínimos de hipnosis clínica que el especialista en cuidados paliativos tiene que conocer para su aplicación. Se enfatiza que se trata de un fenómeno neurológico normal con bases científicas sólidas y puede ser espontáneo o inducido. Se aclaran algunos conceptos erróneos y se sugieren algunos lineamientos aplicables a los cuidados paliativos ya que este grupo tiene necesidades distintas al del resto de pacientes. Sugerimos entrenamiento formal y presentamos dos casos típicos. Abstract: The purpose of the present paper is to describe the minimal clinical hypnosis principles that any palliative care specialist must possess for the application of the technic at the clinical field. It is emphasized that this is a normal neurological phenomenon scientifically based and may be spontaneous or induced. It clarifies some misconceptions and suggests some guidelines applicable to palliative care treatments as this group has different needs than the rest of patients. We suggest formal training and present two typical cases. Uno de los temas más controversiales en medicina es el de la hipnosis médica, pues lamentablemente la mayoría de la información llega más bien a través de la TV o el cine presentando un cuadro bizarro de lo que es este campo. Este artículo presenta los conceptos en boga y aclarará la utilidad de la hipnosis como herramienta médica que conviene conocer y aplicar. La llamada hipnosis es un estado de consciencia diferente a la vigilia, es un estado especial y único pero normal. Es más cercano a la concentración mental activa que al sueño como sugiere el nombre, y sus mecanismos se han estado dilucidando lenta pero seguramente. A la luz de los conocimientos neurocientíficos actuales la consciencia ordinaria, la vigilia normal es un continuum de estados de consciencia durante los cuales se presentan cíclicamente la formación activa de proteínas impulsada por genes dependientes de la actividad. Hace décadas que se dejó de

The impact of a suggestion for posthypnotic amnesia on material learned either before or during hypnosis was investigated across 2 experiments. In Experiment 1, very high, high, and low hypnotizable participants learned a word list either before or immediately after a hypnotic induction. During hypnosis, participants were given a suggestion for posthypnotic amnesia for the word list. After hypnosis, they were tested on recall, word-fragment, and word-recognition tasks. Experiment 2 replicated and extended Experiment 1 through application of the real-simulating paradigm. Across the 2 experiments, there was no difference in the performance of participants who learned the word list either before or during hypnosis. Although amnesia on direct memory measures was associated with high hypnotizability (Experiment 1), an explanation based on demand characteristics could not be excluded (Experiment 2). The implications of these findings for the use of posthypnotic amnesia as a laboratory analog of disorders of autobiographical memory are discussed.

Evidence supports the efficacy of hypnotic treatments, but there remain many unresolved questions regarding how hypnosis produces its beneficial effects. Most theoretical models focus more or less on biological, psychological, and social factors. This scoping review summarizes the empirical findings regarding the associations between specific factors in each of these domains and response to hypnosis. The findings indicate that (a) no single factor appears primary, (b) different factors may contribute more or less to outcomes in different subsets of individuals or for different conditions, and (c) comprehensive models of hypnosis that incorporate factors from all 3 domains may ultimately prove to be more useful than more restrictive models that focus on just 1 or a very few factors.

The phenomenology of the unfolding elaboration of our capacity to know Being directly and as well as our experience to know Being through beings is the focus of this paper. I will focus on the phenomenological elaboration of our knowing of mind; the phenomenological knowing of direct awareness and the consequent simultaneous intertwining of knowing through mind and through awareness. This union of our mind and our awareness allows the knowing of Being through beings and knowing the indivisibleness of beings and Being. As the Dakini said to Dudjom Lingpa " You and I are indivisible. " Our paper begins with a phenomenological elaboration of the Two Ways of Knowing. This is a necessary and a most useful distinction for our knowing of both beings and Being simultaneously. The Two Ways of Knowing: Mind Knowing Form and Awareness Knowing Being Mind Knows Form! Our mind knows forms, and things, both subtle and gross. Our mind knows beings and things. Our mind knows subject and our mind knows otherness. Our mind knows dualities .Our mind knows me and you, us and them and this and that. Mind knows time. Our mind knows the sense of the past, the sense of present and a sense of the future. The mind knows entities. Our mind knows difference. Our mind thinks conceptually, feels affectively, imagines through images, the mind senses sensation and the mind has memory. The mind always knows dualistically. Our mind thinks and knows through thoughts, our mind feels and knows through feelings, our mind has sensations, knows through sensation and our mind has fantasy and knows through imagination. The knowledge of our mind is mediated through conceptualization and representational thinking. Our mind can even know the mind of others. However, our mind cannot know Being and our mind cannot know the Being-ness of beings. Our mind cannot experience Being. Our mind cannot know Being directly. Awareness Knows Being! Our awareness directly knows Being and our awareness can directly know the Being-ness of beings. Being itself is not a being and Being manifests beings, infinite numbers of beings. Being manifests Being within beings as their own being. Being itself is not an entity and Being is not a being. Being is not a thing. Being is non-duality. Being knows the non-duality of everything and anything. Being is oneness and pervasiveness. Being is openness, and Being self-manifests as radiant light. Being is compassionate creative resonance. Being manifests presence. Our awareness can know the indivisible presence of the Being-ness of beings within beings and between beings. Being manifests duality, although Being is completely non-dual. By becoming aware of awareness, we experience primordial awareness which is the ground of being, which is Being itself. Awareness is Being. Awareness is Being knowing Being. Being knows Being and is the Being-ness of all the beings. Awareness can be timeless as well as awareness can be in time. Awareness can be timelessness and in time simultaneously.

This article takes its inspiration from Wickramasekera II’s empathic involvement theory of hypnosis. That model illuminates the mutual territory of hypnosis and empathy—common to much interaction between hypnotist and subject, and to the internal process of subjects as they enact suggestions of the hypnotist. However, the present article suggests that the overlap is not as ubiquitous as the empathic involvement theory asserts. Other aspects of hypnosis involve disengagement from real persons in the environment and dissociating from other ego states of the self. Amnesia and certain uses of focused attention in the hypnotic context run counter to empathy. The fantasizer type of high hypnotizables experiences hypnosis more empathically than do the equally hypnotizable dissociater type. This article also explores the relationship of hypnosis and empathy to other related states, including meditation, dreaming, and psychedelic drugs. The conclusion is that empathy is an important component of many hypnotic phenomena, but that the relationship is as partial and complex as the manner in which other traits, such as imagery ability and dissociation, map onto hypnosis.

Cutaneous and bronchial immediate allergic reactivity and the serum level of IgE specific for each of four common inhalant allergens were determined for 153 asthmatic patients. Positive bronchial reactivity to an extract was not detected in any of the patients with a negative prick test reaction to that extract but did occur in 9% of the patients in whom the serum tests results for IgE specific to that allergen fell within the range regarded as negative. Highly significant correlation coefficients between the degree of bronchial and cutaneous allergic reactivity to the allergen extracts were found and these were slightly but significantly less than the correlation between the serum level of allergen specific IgE and the degree of bronchial allergic reactivity to the allergen extracts. These findings indicate that the results both of prick testing with appropriate extracts and estimation of the serum level of allergen specific IgE can be used to predict not only the presence of detectable bronchial reactivity to inhalant allergens but also the degree of this reactivity. However, for the routine investigation of asthmatic patients measurement of the serum level of allergen specific IgE would appear to have little advantage over properly performed prick tests.

Carl Jung describes how the human unconscious is the hidden cosmological archetypal dimension of our being in the world. There is the personal unconscious that reflects personal history and experience either forgotten or foreclosed. There is another unconscious that is more primary, pre-reflective and cosmological in origin. In the language of the ancient Phenomenological Dzogchen tradition of Tibetan Buddhism, this existential dimension of archetypal manifestation is called the Sambogakaya realm of experience. This is the subtle realm of lucid forms of light and energy and vortices. These forms of light and energy field configurations become everything and anything. The Sambogakaya dimension manifests the Nirmanakaya dimension. The Nirmanakaya dimension is the actual experience of our self in contextual situations, unfolding through time and space as well as our unfolding of our personal psychological experience. Nirmanakaya is the dimension of our ordinary life world. Nirmanakaya is our being in the world. There is one more dimension. This dimension is the primordial foundational ground of everything and anything. In the ancient tradition of Dzogchen this is named as the Dharmakaya. Dharmakaya is the existential dimension of pure potentiality, pure creativity from which everything and anything manifests. Dharmakaya manifests the Sambogakaya. Dharmakaya is ground awareness, the ground of being. Dharmakaya is Being. Being is not a being but Being manifesting being as infinite numbers of numerous beings. All beings are the manifestation of Being. Dharmakaya is not an entity but manifests infinite numbers of entities.