Crypt

My presentation will focuses on the painted decoration of the crypt of S. Filastrio in the old cathedral of Brescia, known as the Rotonda. Starting from Marco Rossi's work from 2004, I will attempt to argue new insights into the iconography of the central apse. To do so, it is first useful to reflect on the construction phases of the crypt, in order to indirectly propose a dating of the wall paintings and consequently a patronage scenario. Next, I will attempt to reconstruct the apsidal theophany in detail. At that point, I will try to frame the rare iconography, questioning the relationship with the liturgical space.

Background Ulcerative colitis (UC) is a chronic relapsing large intestine condition of inflammatory origin1. One of the most common features of UC is the injury of the intestinal barrier, which is composed primarily of colonic epithelial cells (CEpCs)2. The aim of this study was to identify UC-induced miRNA markers in CEpCs by determining the miRNA expression profile changes in crypt-top and crypt-bottom CEpC populations during active (aUC) and inactive (iUC) UC. Methods Crypt-top and crypt-bottom CEpCs were sorted from biopsies of healthy control (HC) individuals (n=19), patients with aUC (n=17) and iUC (n=15) using FACS technology. Total RNA was extracted, small RNA sequencing libraries were prepared and sequenced using Illumina platform. Sequencing data was processed with nextflow-core/smrnaseq pipeline. Differential expression, correlation, miRNA-target interactions, gene set enrichment analyses and data visualisation were performed using Rstudio software packages DESeq2, isomiR...