PXRD
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Zinc chloride is an important pharmaceutical/nutraceutical compound used as a source of zinc. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield... more
Zinc chloride is an important pharmaceutical/nutraceutical compound used as a source of zinc. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, thermal, and behavioral properties of zinc chloride using PXRD, PSD, FT-IR, UV-vis, and DSC analysis. Zinc chloride was divided into two parts – one part was control, while another part was treated with The Trivedi Effect® remotely by seven renowned Biofield Energy Healers and defined as The Trivedi Effect® Treated sample. A significant alteration of the crystallite size and relative intensities of the PXRD peaks was observed in The Trivedi Effect® treated sample compared with the control sample. A sharp peak at 2θ equal to 16.58° was observed in the control sample, but it was disappeared in the treated sample. The average crystallite size of the treated sample was significantly reduced by 21.31% compared with the control sample. The particle size values at d10, d50, and d90 were significantly decreased by 8.15%, 6.28%, and 5.26%, respectively in the treated sample compared with the control sample. The surface area of the treated sample was significantly increased by 7.14% compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control and treated sample were found at 510 cm-1 and 511 cm-1, respectively. The UV-vis analysis exhibited that wavelength of the maximum absorbance (λmax) of both the control and treated samples was at 196 nm. The DSC analysis exhibited that the melting and decomposition temperature were decreased by 0.29% and 0.28%, respectively in the treated zinc chloride compared to the control sample. The latent heat of fusion of the treated sample (370.48 J/g) was increased significantly by 97.71% compared with the control sample (187.39 J/g). This results indicated that zinc chloride need more heat energy to undergo the process of melting after Biofield Energy Treatment. The enthalpy of decomposition of the treated sample was significantly decreased by 15.40% compared with the control sample. The current study anticipated that The Trivedi Effect®-Energy of Consciousness Healing Treatment might lead to produce a new polymorphic form of zinc chloride, which would be more soluble, bioavailable and latent heat of fusion compared with the untreated compound. Hence, the treated zinc chloride would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic response against inflammatory diseases, immunological disorders, aging, stress, cancer, etc.
Magnesium gluconate is usually used as a dietary supplement for the prevention and treatment of hypomagnesemia as well as to maintain the overall quality of life. The present study was designed to evaluate the impact of The Trivedi... more
Magnesium gluconate is usually used as a dietary supplement for the prevention and treatment of hypomagnesemia as well as to maintain the overall quality of life. The present study was designed to evaluate the impact of The Trivedi Effect®-Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of magnesium gluconate using PXRD, PSA, DSC, and TGA/DTG analysis. Magnesium gluconate was divided into two parts – one part was control (without Biofield Energy Treatment), while another part was treated with Energy of Consciousness Healing Treatment (The Trivedi Effect®) remotely by the renowned Biofield Energy Healer, Alice Branton and defined as Biofield Energy Treated sample. The PXRD analysis showed that the relative peak intensities and crystallite sizes of the characteristic diffraction peaks in the treated sample were significantly altered from -73.55% to 17.21% and from -14.28% to 125.11%, respectively compared with the control sample. The average crystallite size was significantly increased by 19.29% in the treated sample compared to the control sample. The particle size values at d10, d50, d90, and D(4, 3) of the treated sample was significantly increased by 2.03%, 70.92%, 142.25%, and 95.42%, respectively compared with the control sample. Thus, the surface area of treated sample was significantly decreased by 21.34% compared to the control sample. The melting point of the Biofield Energy Treated sample (170.16°C) was decreased by 0.19% compared the control sample (170.48°C). The latent heat of fusion in the treated sample was increased by 3.11% compared to the control sample. The TGA analysis exhibited three steps thermal degradation and the total weight loss of the treated sample was increased by 0.29% compared to the control sample. The maximum thermal degradation temperatures (Tmax) of the 1st and 2nd peaks were decreased by 2.86% and 1.97%, respectively, while 2nd and 3rd peaks were increased by 1.14% and 0.94% respectively, in the treated sample compared to the control sample. The thermal analysis revealed that the thermodynamic stability of the treated sample was changed compared with the control sample. The Energy of Consciousness Healing Treatment might produce a crystalline polymorphic form of magnesium gluconate, which could show better powder flowability and appearance with altered thermal stability compared to the untreated sample. Hence, Biofield Energy Treated magnesium gluconate would be advantageous in designing better nutraceutical/pharmaceutical formulations that might provide better therapeutic responses against inflammatory diseases, immunological disorders, cancer, diabetes mellitus, stress, aging, etc.
Vitamin D3 or cholecalciferol is a secosteroid nutraceutical used for the prevention and treatment of vitamin D deficiency. The objective of this study was to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing... more
Vitamin D3 or cholecalciferol is a secosteroid nutraceutical used for the prevention and treatment of vitamin D deficiency. The objective of this study was to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of cholecalciferol using PXRD, PSA, DSC, and TGA/DTG analysis. Cholecalciferol was divided into two parts, one part of cholecalciferol was considered as control (no Biofield Treatment was provided), while second part received The Trivedi Effect® - Biofield Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The PXRD analysis exhibited that the relative intensities of characteristic diffraction peak in the Alice’s treated cholecalciferol were significantly altered from -28.21% to 54.16% compared with the control sample. The crystallite size of the treated sample was altered from -40.02% to 83.20% compared with the control sample. The particle size values at d10, d50, d90, and D(4, 3) in Alice’s treated sample were significantly reduced by 33.48%, 23.82%, 18.61%, and 22.08%, respectively compared to the control sample. The specific surface area of treated cholecalciferol was significantly increased by 32.72% compared to the control sample. The DSC analysis demonstrated that the melting point of the treated sample was higher by 0.24% with an enhanced latent heat of fusion (∆H) by 3.54% compared to the control sample. The decomposition temperature of the treated cholecalciferol was increased by 0.12% with a significant increase of the enthalpy of decomposition by 5.85% compared to the control sample. The melting temperature and ∆H of a second broad endothermic peak in the treated sample were increased by 0.18% and 73.87%, respectively compared to the control sample. The TGA analysis revealed that the weight loss in the treated sample was decreased compared with the control sample. The DTG analysis indicated that the maximum thermal degradation temperature of the treated cholecalciferol was increased by 3.23% compared to the control sample. Overall, the thermal analysis indicated that the thermal stability of the treated cholecalciferol was improved compared to the control sample. Thus, The Trivedi Effect® might lead to produce a polymorphic form of cholecalciferol which might have the improved solubility, bioavailability, and thermally stability as compared with the untreated sample. The Biofield Energy Treated cholecalciferol would be beneficial to design better nutraceutical and pharmaceutical formulations, which could provide better therapeutic response against vitamin D deficiency i.e. rickets, osteoporosis, cancer, diabetes mellitus, etc.
Berberine is one of the well-known traditional Chinese medicines and it has been significantly effective against various ailments. This study was performed to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing... more
Berberine is one of the well-known traditional Chinese medicines and it has been significantly effective against various ailments. This study was performed to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on its physicochemical properties by using PXRD, PSA, TGA/DTG, and DSC analytical techniques. The sample was divided into two parts; the first part was considered as a control sample (without treatment), while the second part was received the Consciousness Energy Healing Treatment remotely by the Biofield Energy Healer, Gopal Nayak and denoted as the treated sample. The PXRD peak intensities and crystallite sizes were altered ranging from -28.78% to 115.15% and -15.76% to 241.38%, respectively; however the average crystallite size was increased significantly by 23.05% in the treated sample compared to the control sample. The particle sizes were significantly increased by 16.89% (d10), 34.41% (d50), 21.88% (d90), and 22.85 % {D (4,3)}, which resulted in the significant increase in the specific surface area by 14.74% in the treated sample compared to the control sample. The thermal analysis indicated 3.98% increase in weight loss and 3.64% decrease in the residue weight of the treated sample compared to the control sample. The latent heat for the 1st, 2nd, 3rd, 4th, 5th, and 6th peaks of the treated sample were significantly altered by 224.78%, 7.93%, 8.92%, -9.05%, -45.82%, and 10.93%, respectively, compared to the control sample. The overall analysis indicated that the Trivedi Effect®-Consciousness Energy Healing Treated berberine chloride might possess better solubility, absorption, and thermal stability compared to the untreated sample. Thus, the Trivedi Effect® could be used in improving the bioavailability of berberine chloride and might be used for designing the novel nutraceutical/pharmaceutical formulations to combat various diseases.
Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy... more
Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received The Trivedi Effect® Treatment remotely from eighteen renowned Biofield Energy Healers. The PXRD analysis exhibited that both the control and The Trivedi Effect® - Biofield Energy Treated samples were amorphous in nature. The particle size values at d10 and d50 of the treated sample were decreased by 4.66% and 6.02% and at d90 slightly increased by 0.99% compared with the control sample. The average surface area of the treated (0.130 m2/g) sample was increased by 4.84% compared with the control (0.124 m2/g) sample. The FT-IR results suggested that the force constant of O-H (stretching), and C-O (stretching) functional groups of the treated sample were reduced compared with the control sample. The UV-vis analysis revealed that the wavelength for the maximum absorbance of the control and treated samples were at 205.4 nm and 205.6 nm, respectively. The TGA thermograms exhibited three steps of the degradation process, and the total weight loss of the treated (86.45%) sample was increased by 1.44% compared with the control (85.22%) sample. The DSC analysis revealed that melting point of the treated (201.67°C) sample was reduced by 0.87% compared with the control (203.43°C) sample. The latent heat of fusion of the treated (6.77 J/g) sample was significantly decreased by 21.82% compared to the control (8.67 J/g) sample. Hence, the treated sample would be more advantageous for the better therapeutic responses compared to the control sample. These findings suggest that The Trivedi Effect® - Energy of Consciousness Healing Treatment might have the astounding capacity to enhance the solubility, dissolution, absorption, and bioavailability of ashwagandha root extract in various forms of pharmaceutical/nutraceutical formulations by modifying its particle size and surface area. Thus, The Trivedi Effect® - Energy of Consciousness Healing Treated ashwagandha root extract might provide better therapeutic response against inflammatory diseases, immunological disorders, stress, arthritis, cancer, diabetes, sexual disorders, aging and other chronic infections.
- by Mahendra Kumar Trivedi and +20
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- Withania Somnifera, DSC, TGA, Particle Size
- by Mahendra Kumar Trivedi and +20
Cholecalciferol is a steroid hormone (7-dehydroxycholesterol), which helps in the absorption of dietary minerals like zinc, calcium, magnesium, iron, and phosphate and also responsible for other biological activity. In this research... more
Cholecalciferol is a steroid hormone (7-dehydroxycholesterol), which helps in the absorption of dietary minerals like zinc, calcium, magnesium, iron, and phosphate and also responsible for other biological activity. In this research study, the influence of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of cholecalciferol was evaluated using the modern analytical technique. The cholecalciferol test sample was divided into two parts. One of the test samples was considered as a control sample, which did not receive the Biofield Energy Treatment; whereas, the other part was treated with the Consciousness Energy Healing Treatment remotely by a well-known Biofield Energy Healer, Gopal Nayak and termed as a treated sample. The particle size values in the treated cholecalciferol powder sample were significantly decreased by 78.94% (d10), 26.21% (d50), 22.01% (d90), and 29.04% {D (4,3)}; thus, the specific surface area of the treated cholecalciferol was significantly increased by 174.12% compared to the control sample. The XRD peak intensities and crystallite sizes of the treated cholecalciferol powder sample were significantly altered ranging from -44.37% to 370.49% and -74.48% to 91.52%, respectively; therefore, the average crystallite size of the treated cholecalciferol was significantly decreased by 36.21% compared to the control cholecalciferol. The latent heat of fusion of the treated cholecalciferol was significantly increased by 25.89% compared to the control cholecalciferol. The weight loss was decreased by 1.48%; whereas, the residue amount was significantly increased by 107.02% in the treated sample compared with the control sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treatment generated a new polymorphic form of cholecalciferol which might offer better solubility, absorption, bioavailability, and be thermally more stable compared with the control sample. Henceforth, the Consciousness Energy Healing Treated cholecalciferol would be more beneficial to maintain the overall quality of life and it would be more useful in designing novel nutraceutical/pharmaceutical formulations for the better therapeutic responses against deficiency of vitamin D, osteoporosis, rickets, cardiovascular diseases, diabetes mellitus, cancer, mental disorders, multiple sclerosis, etc.
Withania somnifera (Ashwagandha) root extract and their active metabolites possess a broad range of pharmacological activities. The current study aimed to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing... more
Withania somnifera (Ashwagandha) root extract and their active metabolites possess a broad range of pharmacological activities. The current study aimed to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts – one part was control without any and another part was treated with The Trivedi Effect® - Energy of Consciousness Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as The Trivedi Effect® treated sample. The PXRD analysis exhibited that both the treated and control samples were amorphous in nature. The particle sizes at d10, d50, and d90 values of the treated sample were significantly decreased by 12.23%, 10.97%, and 1.25%, respectively with respect to the control sample. The surface area analysis revealed that the surface area of the treated sample was significantly increased by 14.29% as compared to the control sample. The FT-IR analysis indicated the alteration of the force constant for the functional groups of the treated sample in comparison to the control sample. The UV-vis analysis revealed that the wavelength for the maximum absorbance of the control and treated samples were at 205.8 and 206.0 nm, respectively. The TGA analysis revealed that the total weight loss was decreased by 0.70% in the treated sample as compared to the control sample. This indicated that the treated sample was thermally more stable as compared to the control sample. The DSC analysis indicated that the melting point of the treated sample (190.48°C) was decreased by 4.91% than the control sample (203.45°C). The latent heat of fusion of the treated (4.94 J/g) sample was significantly decreased by 42.96% compared with the control (8.66 J/g) sample. The current findings suggest that The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing) might have the astounding capacity to enhance the solubility, absorption, dissolution, and finally, bioavailability of ashwagandha root extract in various form of pharmaceutical and nutraceutical formulation by modifying its particle size and surface area. Thus, the treated ashwagandha root extract might provide better therapeutic response against against inflammatory diseases, immunological disorders, stress, arthritis, cancer, diabetes, sexual disorders, aging and other chronic infections.
- by Mahendra Kumar Trivedi and +19
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- Withania Somnifera, DSC, TGA, Particle Size
- by Mahendra Kumar Trivedi and +19
Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness... more
Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and another part was treated with The Trivedi Effect®-Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as The Trivedi Effect®-Energy of Consciousness Healing Treated sample. The PXRD analysis showed the significant alteration of the crystallite size of the treated sample in the range of -36.36% to 133.24% as compared to the control sample. However, the average crystallite size of the treated sample was significantly decreased by 8.31% as compared to the control sample. Overall, the crystal morphology of the treated sample was different from the control sample. The particle sizes d10, d50, and d90 values of the treated sample were significantly decreased by 3.40%, 9.75%, and 8.52%, respectively as compared to the control sample. Consequently, the surface area of the treated sample was significantly increased by 5.26% from the control sample. Both the control and treated FT-IR spectra indicated the presence of sharp and strong absorption bands at 887 cm-1 due to the Se=O stretching. The UV-vis spectroscopic analysis displayed that the wavelength for the maximum absorbance of both the control and treated samples were at 204.1 and 204.0 nm, respectively. TGA analysis revealed that the total weight loss of the treated sample was reduced by 1.24% as compared with the control sample. The DSC analysis showed that the treated sample (588.77°C) had higher melting point than the control sample (588.60°C). The latent heat of fusion was reduced in the treated sample by 8.01% compared to the control sample. Thus, The Trivedi Effect®-Biofield Energy Healing might lead to generate a new polymorphic (enantiotropic) form of sodium selenate which would be more soluble, bioavailable, and thermally stable compared with the untreated sample. The Trivedi Effect treated sodium selenate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might offer better therapeutic response against inflammatory diseases, immunological disorders, stress, aging, infectious diseases, cancer, diabetes, heart diseases, Alzheimer’s disease, etc.
Pyridoxine hydrochloride is water-soluble B vitamin widely used for the prevention and treatment of vitamin B6 deficiency and other several diseases. The aim of this study was to explore the effect of The Trivedi Effect® - Energy of... more
Pyridoxine hydrochloride is water-soluble B vitamin widely used for the prevention and treatment of vitamin B6 deficiency and other several diseases. The aim of this study was to explore the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of pyridoxine hydrochloride using PXRD, PSA, DSC, and TGA/DTG analysis. Pyridoxine hydrochloride was divided into two parts, one part of pyridoxine hydrochloride was considered as control (no Biofield Treatment was provided), while second part received The Trivedi Effect® - Biofield Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The PXRD analysis exhibited that the relative intensities and crystallite sizes of the most characteristic diffraction peaks in the Alice’s treated pyridoxine hydrochloride were significantly decreased from 1.59% to 44.47% and 6.31% to 28.28%, respectively compared with the control sample. Overall, the average crystallite size of the treated sample was significantly reduced by 5.55% compared with the control sample. The particle size values at d10, d50, d90, and D(4, 3) (average mass-volume diameter) in Alice’s treated sample were significantly reduced by 13.87%, 9.95%, 7.87%, and 6.59%, respectively compared to the control sample. The specific surface area of treated sample was significantly increased by 13.67% compared to the control sample. The DSC analysis revealed that the melting point of the treated sample was lower by 0.20% with a significant reduction of the latent heat of fusion by 24.52% compared with the control sample. The TGA analysis revealed that the total weight loss in the treated sample was increased by 1.76% compared with the control sample. The DTG analysis indicated that the maximum thermal degradation temperature of the treated sample was reduced by 0.88% compared to the control sample. Overall, the thermal analysis indicated that the thermal stability of the treated pyridoxine hydrochloride was declined compared to the control sample. Thus, The Trivedi Effect® might lead to the production of a polymorphic form of pyridoxine hydrochloride which would be more soluble, absorbable, have a higher dissolution rate and be more bioavailable compared with the untreated sample. The Biofield Energy Treated pyridoxine hydrochloride would be beneficial in the design of better nutraceutical and pharmaceutical formulations which might provide better therapeutic responses against vitamin B6 deficiency, sideroblastic anemia, cardiovascular disease, diabetes, Alzheimer’s disease, pyridoxine-dependency seizures, metabolic disorders, pulmonary tuberculosis, hyperhomocysteinemia, cancer, anxiety, asthma, depression, dysmenorrhea, etc.
Zinc chloride is an important pharmaceutical/nutraceutical mineral for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of Consciousness... more
Zinc chloride is an important pharmaceutical/nutraceutical mineral for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, thermal, and behavioral properties of zinc chloride using PXRD, PSD, FT-IR, UV-vis, and DSC analysis. Zinc chloride was divided into two parts – one part was control, while another part was treated with The Trivedi Effect® remotely by seven renowned Biofield Energy Healers and defined as The Trivedi Effect® treated sample. A significant alteration of the crystallite size and relative intensities of the PXRD peaks were observed in The Trivedi Effect® treated sample with respect to the control sample. A sharp peak at 2θ equal to 51.45°, which was observed in the control sample was disappeared in the treated sample. The average crystallite size of the treated sample was decreased by 2.13% compared with the control sample. The size of the particles at d10, d50, and d90 was decreased by 3.36%, 7.97%, and 11.51%, respectively in the treated sample compared with the control sample. The surface area of the treated sample was significantly increased by 5.69% compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control was 646 cm-1, whereas it was significantly shifted downward to 505 cm-1in the treated sample. The UV-vis analysis exhibited that wavelength of the maximum absorbance (λmax) of both the control and treated samples was at 196.4 nm. The DSC analysis exhibited that the melting and decomposition temperature were increased by 0.93% and 0.56%, respectively in the treated zinc chloride compared to the control sample. The enthalpy of fusion of the treated sample (338.27 J/g) was increased significantly by 33.84% compared with the control sample (252.75 J/g). The enthalpy of decomposition of the treated sample was increased by 3.78% compared with the control sample. The current study anticipated that The Trivedi Effect®-Energy of Consciousness Healing Treatment might lead to produce a new polymorphic form of zinc chloride, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. The treated sample could be more stable during manufacturing, delivery or storage conditions than the untreated sample. Hence, the treated zinc chloride would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic response against inflammatory diseases, immunological disorders, aging, stress, cancer, etc.
The purpose of this investigation was to develop solid dispersion (SD) formulation of cyclosporine (CyA) using polyethylene glycol (PEG-6000) to enhance its dissolution rate followed by nondestructive method for the prediction of both... more
The purpose of this investigation was to develop solid dispersion (SD) formulation of cyclosporine (CyA) using polyethylene glycol (PEG-6000) to enhance its dissolution rate followed by nondestructive method for the prediction of both drug and carrier. SD formulations were prepared by varying the ratio of CyA and PEG-6000 by solvent evaporation technique and characterized by dissolution, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), near infrared (NIR) and near infrared chemical imaging (NIR-CI). Dissolution data revealed enhanced dissolution of CyA when compared with pure CyA. DSC results showed that the crystallinity of PEG-6000 has decreased as indicated by decrease in the enthalpy of fusion and melting peak in the formulations. FTIR data demonstrated no chemical interaction between drug and carrier. The surface morphology of SD formulations was similar to PEG-6000 particle. NIR-CI disclosed homogeneity of SD matrix as indicated by symmetrical histograms with smaller values of skewness. Similar to NIR, a multivariate peak evaluation with principal component analysis and partial least square (PLS) were carried out with PXRD spectral data. PLS models with both techniques showed good correlation coefficient and smaller value of root mean square of errors. The accuracy of model for predicting CyA and PEG-6000 in NIR and PXRD data were 5.22%, 5.35%, 5.27%, and 2.10%, respectively. In summary, chemometric applications of non-destructive method sensors provided a valuable means of characterization and estimation of drug and carrier in the novel formulations.
Magnesium (Mg) is abundantly present in the human body, which is important for many metabolic activities, and normal functioning of cells, muscles, heart, bones, etc. The objective of this study was to evaluate the impact of the Trivedi... more
Magnesium (Mg) is abundantly present in the human body, which is important for many metabolic activities, and normal functioning of cells, muscles, heart, bones, etc. The objective of this study was to evaluate the impact of the Trivedi Effect® on the physicochemical properties of Mg powder using PXRD and PSA analytical techniques. Mg powder sample was divided into two parts, one part of Mg was considered as control (no Biofield Energy Treatment was provided), while the second part received the Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Gopal Nayak and termed as a Consciousness Energy Healing Treated sample. The PXRD peak intensities and crystallite sizes of the treated Mg were significantly altered ranging from 2.86% to 16.51% and 6.79% to 52.30%, respectively compared to the control sample. Overall the average crystallite size of the treated Mg sample was significantly increased by 16.92% compared with the control sample. The particle size values in the treated Mg were significantly decreased by 5.5% (d10), 7.26% (d50), 8.63% (d90), and 7.69% {D(4,3)} compared to the control sample. The specific surface area of Consciousness Energy Healing Treated Mg powder (0.0187m2/g) was significantly increased by 7.47% compared with the control sample (0.0174m2/g). The Trivedi Effect® might lead to generate a new polymorphic form of Mg which would show better solubility in solvents compared with the control sample. The Consciousness Energy Healing Treated Mg would be very useful for the prevention and treatment of many diseases such as hypomagnesaemia, ventricular arrhythmias and the prevention of sudden cardiac death, migraine, inflammatory diseases, immunological disorders, pre-eclampsia, eclampsia, diabetes mellitus, cancer, gestational hypertension, oxidative stress, etc. It would be more beneficial for the designing of nutraceutical/pharmaceutical formulations, and other metal and chemical industries.
- by Mahendra Kumar Trivedi and +2
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- Magnesium, Particle Size, PXRD, The Trivedi Effect®
Silver sulfadiazine is a topical medicine that belongs to sulfa antibiotics class of drugs and used in treating wound infections in burn patients. The aim of this study was to determine the effect of Consciousness Energy Healing Treatment... more
Silver sulfadiazine is a topical medicine that belongs to sulfa antibiotics class of drugs and used in treating wound infections in burn patients. The aim of this study was to determine the effect of Consciousness Energy Healing Treatment (the Trivedi Effect®) on the various properties of silver sulfadiazine with the help of modern analytical techniques. The sample was divided into two parts; the first part was not given any treatment and considered as a control sample, while the second part was provided the Consciousness Energy Healing Treatment by the Biofield Energy Healer, Gopal Nayak remotely, named as the treated sample. The powder XRD data showed significant alterations in the peak intensities of the treated sample ranging from-30.71% to 47.54% compared to the control sample. The crystallite size was altered ranging from -78.12% to 1.47%; and the average crystallite size was significantly reduced by 31.62% in the treated sample compared to the control sample. The particle sizes were decreased in the treated sample by 12.75%(d10), 4.98%(d50), 0.89%(d90), and 2.92%{D(4,3)}; thus, the specific surface area was significantly increased by 17.31% compared with the control sample. The latent heat of fusion and latent heat of decomposition were profoundly increased by 24.62% and 156.28%, respectively in the treated sample compared to the control sample. The total weight loss was increased by 3.08% and the residue amount was reduced by 4.44% in the treated sample compared to the control sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treated sample might form a new polymorph of silver sulfadiazine that possesses reduced particle size and improved thermal properties compared to the untreated sample. Therefore, the Biofield Energy treated sample can be used in nutraceutical/pharmaceutical formulation, which would show a better bioavailability and therapeutic response against various infections in comparison to the control sample.
Magnesium gluconate is a potent antioxidant and widely used for the prevention and treatment of hypomagnesia. The current research was aimed to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on... more
Magnesium gluconate is a potent antioxidant and widely used for the prevention and treatment of hypomagnesia. The current research was aimed to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on magnesium gluconate for the change in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with The Trivedi Effect® - Energy of Consciousness Healing Treatment remotely by seven renowned Biofield Energy Healers and defined as The Trivedi Effect® Treated sample. The PXRD analysis exhibited that the crystallite size of the treated sample was remarkably changed from - 24.96% to 99.98% compared with the control sample. The average crystallite size was significantly increased by 7.79% in the treated sample compared with the control sample. PSD analysis revealed that the particle sizes in The Trivedi Effect® Treated sample at d10, d50 and d90 values were decreased by 5.36%, 11.35% and 0.90%, respectively compared with the control sample. The surface area analysis revealed that surface area of the Biofield Energy Treated sample was significantly increased by 7.48% compared with the control sample. The FT-IR and UV-vis analysis showed that structure of the magnesium gluconate remained the same in both the treated and control samples. The TGA analysis revealed four steps thermal degradation of both the samples and the total weight loss of Biofield Energy Treated sample was increased by 0.12% compared with the control sample. The DSC analysis demonstrated that the melting temperature of the Biofield Energy Treated sample (171.29°C) was increased by 0.18% compared with the control sample (170.99°C). The latent heat of fusion was significantly increased by 27.09% in the treated sample compared with the control sample. The current study revealed that The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) might lead to a new polymorphic form of magnesium gluconate, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. The Biofield Treated sample could be more stable during manufacturing, delivery or storage conditions than the untreated sample. Hence, The Trivedi Effect® Treated magnesium gluconate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging, and other chronic infections.
- by Mahendra Kumar Trivedi and +9
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- DSC, TGA, Particle Size, PXRD
Copper (II) chloride is an inorganic compound used as a source of copper ions for the treatment of several diseases like cancer, inflammation, hematological and neurological disorders. This article was aimed to evaluate the effect of The... more
Copper (II) chloride is an inorganic compound used as a source of copper ions for the treatment of several diseases like cancer, inflammation, hematological and neurological disorders. This article was aimed to evaluate the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of copper (II) chloride using PXRD, DSC, and TGA/DTG analysis. Copper chloride was divided into two parts, one part of copper chloride was considered as control (no Biofield Treatment was provided), while second part received The Trivedi Effect® - Biofield Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The PXRD analysis showed that the relative intensities of the characteristic diffraction peak in Alice’s treated sample were significantly changed from -77.37% to 205.56% compared with the control sample. The crystallite size of the characteristic diffraction peak in the treated sample was altered from -14.29% to 40.01% compared with the control sample. The DSC analysis showed that the melting point of the treated copper chloride was significantly increased by 2.91% with a reduced latent heat of fusion (∆H) by 28.73% compared to the control sample. The melting temperature of the 2nd peak in the treated sample was significantly increased by 7.08% with a significant enhancement of ∆H by 77.37% compared with the control sample. The decomposition temperature of the treated sample was increased by 2.36% with a significant reduction of the enthalpy of decomposition by 18.46% compared with the control sample. The TGA analysis revealed the three steps of thermal degradation. The percentage weight loss in the treated sample was decreased by 0.47% and 9.63% in the 1st and 2nd steps of degradation, respectively, while the weight loss in the 3rd step was increased by 2.45% compared with the control sample. The total weight loss in the treated sample was increased by 1.32% compared with the control sample. The DTG analysis showed that the maximum thermal degradation temperature (Tmax) in the 1st, 2nd, and 3rd peaks of the Biofield Treated sample were increased by 1.20%, 2.00%, and 4.61% compared with the control sample. Briefly, The Trivedi Effect® - Energy of Consciousness Healing Treatment might produce a polymorphic form of copper (II) chloride that could be more stable during manufacturing, delivery or storage conditions than the untreated sample. The Biofield Energy Treated copper chloride would provide better therapeutic response against cancer, inflammation, wound healing, etc.
Magnesium gluconate is an organometallic pharmaceutical/nutraceutical used for the prevention and treatment of various diseases caused by the low level of magnesium. The aim of the present study was to investigate the influence of The... more
Magnesium gluconate is an organometallic pharmaceutical/nutraceutical used for the prevention and treatment of various diseases caused by the low level of magnesium. The aim of the present study was to investigate the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing) on the physicochemical, thermal, structural, and behavioral properties of magnesium gluconate using powder PXRD, PSD, FT-IR, UV-visible, TGA, and DSC analysis. Magnesium gluconate was divided into two parts - one part was denoted as the control, while the another part was treated with The Trivedi Effect® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect® Treated sample. The PXRD analysis exhibited the significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was significantly altered from -39.99% to 62.57% compared with the control sample. The average crystallite size of the treated sample was decreased by 9.71% compared with the control sample. Particle size of the treated sample at d10, d50, and d90 value was significantly increased by 5.36%, 23.10% and 11.11%, respectively compared with the control sample. The surface area of the treated sample was significantly decreased by 9.76% compared to the control sample. The FT-IR and UV-vis analysis showed that the structural characteristic of the magnesium gluconate remained same in the treated sample compared with control sample. The TGA data revealed that the weight loss of the treated sample in the first and third steps of degradation was increased by 31.58% and 5.94%, respectively, whereas in the second step of degradation, the weight loss was decreased by 7.57% compared with the control sample. The DSC analysis showed that the melting point of the control and treated samples were at 170.29°C and 169.76°C, respectively. The latent heat of fusion of the treated sample was increased by 4.18% compared with the control sample. The current study evaluated that The Trivedi Effect® - Energy of Consciousness Healing Treatment might lead to a new polymorphic form of the magnesium gluconate, which could be more soluble, powder flowability and long-term storage stability compared with the control sample. Hence, the Trivedi Effect® Treated magnesium gluconate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might provide better therapeutic response against inflammatory diseases, immunological disorders, and other chronic infections.
- by Mahendra Kumar Trivedi and +20
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- DSC, TGA, Psd, PXRD
- by Mahendra Kumar Trivedi and +20
Zinc chloride has the importance in pharmaceutical/nutraceutical industries for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of... more
Zinc chloride has the importance in pharmaceutical/nutraceutical industries for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on physical, structural, and thermal properties of zinc chloride using PXRD, PSD, FT-IR, UV-vis, TGA, and DSC analysis. Zinc chloride was divided into two parts. One part was denoted as the control without any, while the other part was defined as the Trivedi Effect® Treated sample, which received the Trivedi Effect® Treatment remotely from eighteen renowned Biofield Energy Healers. The PXRD analysis revealed that the crystallite size and relative intensities of the PXRD peaks significantly altered in the treated sample compared with the control sample. The crystallite size of treated sample was decreased by 4.19% compared with the control sample. The particle size at d10 and d50 of the Biofield Energy Treated sample decreased by 4.72% and 2.70%, respectively compared with the control sample. But, the particle size of the treated sample increased at d90 by 0.83 compared with the control sample. Consequently, the surface area was increased by 3.22% in the treated sample compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control and treated sample was at 520 cm-1 and 521 cm-1, respectively. The UV-vis analysis exhibited that the wavelength of the maximum absorbance of the control and treated samples was at 196.4 and 196.2 nm, respectively. The TGA thermograms revealed two steps of the thermal degradation and the weight loss of the treated sample was significantly reduced by 22.54% in the 1st step of degradation compared with the control sample. The DSC analysis showed that the enthalpy of decomposition was significantly increased by 34.9% in the treated sample (89.17 J/g) compared with the control sample (66.10 J/g). Overall, DSC and TGA analysis indicated that the thermal stability of the treated sample was increased compared with the control sample. The current study anticipated that The Trivedi Effect®-Energy of Consciousness Healing Treatment might lead to generate a new polymorphic form of zinc chloride, which would be more soluble, stable, and higher absorption rate compared with the control sample. Hence, the treated zinc chloride could be very useful to design the various forms of nutraceuticals and pharmaceutical formulation which might be providing a better therapeutic response against inflammatory diseases, immunological disorders, aging, stress, cancer, etc.
- by Mahendra Kumar Trivedi and +20
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- TGA, Surface Area, Particle Size, PXRD
- by Mahendra Kumar Trivedi and +20
L-cysteine is an essential amino acid that helps in improving the overall health status of humans. The objective of the study was to determine the impact on the physicochemical and thermal properties of L-cysteine after the Trivedi... more
L-cysteine is an essential amino acid that helps in improving the overall health status of humans. The objective of the study was to determine the impact on the physicochemical and thermal properties of L-cysteine after the Trivedi Effect®-Consciousness Energy Healing Treatment using modern analytical techniques. The control sample was kept without any treatment, while the Biofield Treatment was given to the treated sample remotely by a renowned Biofield Energy Healer, Gopal Nayak. The particle size values were significantly reduced by 11.96%(d10), 9.01%(d50), 4.92%(d90), and 7.66% [D (4, 3)], thus, the specific surface area was significantly increased by 14.28% of the treated L-cysteine compared to the control sample. The peak intensities and crystallite sizes were altered ranging from -86.73% to 456.65% and -4.91% to 451.22% respectively, however, the average crystallite size was significantly increased by 87.58% in the treated sample compared to the control sample. The latent heat of decomposition for the 1st and 2nd peak of the treated sample was increased by 12.77% and 5.42% respectively, compared with the control sample. The weight loss was increased by 9.35%; however, the residual weight was significantly reduced by 85.32% in the treated sample compared to the control sample. The maximum thermal degradation temperature of the treated sample was increased by 2.87% compared to the control sample. Hence, the Biofield Energy Treated L-cysteine might show better solubility, dissolution, bioavailability, and be more thermal stability in the pharmaceutical formulations, which would be more efficacious in the treatment of diabetes, cancer, psychosis, and seizures compared to the control sample.
Hydroxypropyl β-Cyclodextrin (HP β-CD) is having a lot of applications in the food, pharmaceutical, nutraceutical, chemical industries, also in the field of environmental and agriculture engineering. This study evaluated the influence of... more
Hydroxypropyl β-Cyclodextrin (HP β-CD) is having a lot of applications in the food, pharmaceutical, nutraceutical, chemical industries, also in the field of environmental and agriculture engineering. This study evaluated the influence of the Trivedi Effect® on the physicochemical and thermal properties of HP β-CD using modern analytical techniques. The test sample was divided into control and treated parts. The control part did not receive the Biofield Energy Treatment; whereas, the treated part was received the Biofield Energy Treatment remotely by a famous Biofield Energy Healer, Gopal Nayak. The particle size values were decreased by 2.16%( d10), 0.65%(d50), 1.22%(d90), and 1%{D(4,3)}; thus, the specific surface area was increased by 1.27% in the treated sample compared to the control sample. The latent heat of fusion of the treated sample was significantly increased by 41.32% compared with the control sample. The total weight loss was decreased; however, the residue amount was significantly increased by 15.53% of the treated sample compared to the control sample. The results indicated that the Biofield Energy Treatment produced a new form of HP β-CD, which may show better solubility, dissolution rate, absorption, bioavailability, and more thermal stability compared to the control sample. The treated sample would be more useful for the improvement of solubility of the lipophilic drugs, preparation of cholesterol free food products, weight loss supplements, etc.
Folic acid is essential in the body for the production of DNA and also plays various vital functions within the body. This study on folic acid was done to analyze the results of the Trivedi Effect® on its physicochemical and thermal... more
Folic acid is essential in the body for the production of DNA and also plays various vital functions within the body. This study on folic acid was done to analyze the results of the Trivedi Effect® on its physicochemical and thermal properties with the help of analytical techniques. The method involves dividing the test sample into two parts. The first part was termed as a control sample, and no treatment was given to it; while the second part received the Biofield Energy Treatment remotely by a renowned Biofield Energy Healer, Gopal Nayak and termed as the treated sample. The study revealed that the particle sizes reduced by 2.86%(d10), 6.34%(d50), 17.22%(d90), and 11.30%{D(4,3)}, thus increased the surface area by 1.72%, in the treated sample compared with the control sample. The PXRD data showed changes in the peak intensities and crystallite sizes ranging from -36.81% to 113.41% and -15.79% to 318%, respectively, thus increased in the average crystallite size by 22.55% of the treated sample compared with the control sample. The TGA analysis of the treated sample revealed a 3.94% increase in total weight loss that resulted in the remarkable reduction in the residual amount by 14.99%, in comparison to the untreated sample. The latent heat of fusion (ΔHfusion) and latent heat of decomposition (ΔHdegradation) were significantly altered by -10.33% and 10.46%, respectively in the treated sample compared to the untreated sample. The study denoted that the Biofield Energy Treatment is a novel approach that could be used to develop some polymorph of folic acid and that might improve its solubility, dissolution, and bioavailability in comparison to the control sample. Hence, the treated folic acid in the nutraceutical/pharmaceutical formulations might be useful concerning better drug performance and efficacy.
- by Mahendra Kumar Trivedi and +2
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- Folic acid, DSC, Particle Size, PXRD
Mercaptopurine is an antineoplastic chemotherapy drug is used for the treatment of cancer, Crohn's disease, ulcerative colitis, autoimmune diseases, etc. In this scientific study, the impact of the Trivedi Effect®-Consciousness Energy... more
Mercaptopurine is an antineoplastic chemotherapy drug is used for the treatment of cancer, Crohn's disease, ulcerative colitis, autoimmune diseases, etc. In this scientific study, the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of 6-mercaptopurine was evaluated using the modern analytical technique. The test sample 6-Mercaptopurine powder was divided and named into control and treated sample. The control sample did not receive the Biofield Energy Treatment; whereas, the treated sample received the Biofield Energy Treatment remotely by a well-known Biofield Energy Healer, Gopal Nayak. The particle size values in the treated 6-mercaptopurine sample were significantly decreased by 10.18% (d10), 10.59% (d50), 7.62% (d90), and 9.17% {D(4,3)}; thus, the specific surface area was significantly increased by 10.28% compared to the control sample. The powder XRD peak intensities and crystallite sizes of the treated 6-mercaptopurine were significantly altered ranging from -43.40% to 23.33% and -37.09% to 136.67%, respectively; whereas the average crystallite size was significantly decreased by 11.04% compared with the control sample. The latent heat of evaporation and latent heat of fusion of the treated 6-mercaptopurine were significantly increased by 11.81% and 14.97% compared with the control sample. The total residue amount was significantly increased by 6.44% in the treated sample compared with the control sample. The maximum thermal degradation temperature of the 1st, 2nd, and 3rd peaks of the treated sample was altered by 1.55%, 0.18%, and -1.29% compared with the control sample. It was concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new polymorphic form of 6-mercaptopurine which would offer better solubility, absorption, and bioavailability compared with the control sample. The Biofield Energy Treated 6-mercaptopurine would be more efficacious against acute lymphocytic leukemia, chronic myeloid leukemia, Crohn's disease, ulcerative colitis, and autoimmune diseases.
Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of... more
Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical, thermal and behavioral properties of magnesium gluconate using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with the Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as the Biofield Energy Treated sample. The PXRD analysis exhibited significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was remarkably changed from range -33.33% to 66.65% compared with the control sample. The average crystallite size was increased in the treated sample by 6.13% compared with the control sample. Particle size analysis revealed that the particle size at d10 value was significantly reduced in the treated sample by 13.20% compared with the control sample, although the particle size at d50 and d90 values were increased in the treated sample by 2.75% and 3.72%, respectively. The treated sample’s surface area was significantly enhanced (6.96%) compared with the control sample. The FT-IR and UV-vis analysis showed that the structure of magnesium gluconate remained similar in both the treated and control samples. The TGA analysis revealed that the weight loss of the first and second degradation steps in the treated sample was significantly decreased by 2.89% and 8.43%, respectively compared with the control sample, whereas at the third degradation step, the weight loss was enhanced by 14.80% compared with the control sample. The DSC analysis revealed that the melting point of the control and treated samples were 170.23°C and 170.25°C, respectively. The latent heat of fusion was significantly decreased by 6.15% in the treated sample compared with the control sample. The current study infers that The Trivedi Effect® - Energy of Consciousness Healing Treatment might lead to a new polymorphic form of magnesium gluconate, which could be more soluble and bioavailable compared with the untreated compound. Hence, the Biofield Energy Treated magnesium gluconate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging and other chronic infections.
- by Mahendra Kumar Trivedi and +19
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- DSC, TGA, Surface Area, Particle Size
- by Mahendra Kumar Trivedi and +19
Quality by Design (QbD) principles were explored to understand spray drying process for the conversion of liquid nanosuspensions into solid nano-crystalline dry powders using indomethacin as a model drug. The effects of critical process... more
Quality by Design (QbD) principles were explored to understand spray drying process for the conversion of liquid nanosuspensions into solid nano-crystalline dry powders using indomethacin as a model drug. The effects of critical process variables: inlet temperature, flow and aspiration rates on critical quality attributes (CQAs): particle size, moisture content, percent yield and crystallinity were investigated employing a full factorial design. A central cubic design was employed to generate the response surface for particle size and percent yield. Multiple linear regression analysis and ANOVA were employed to identify and estimate the effect of critical parameters, establish their relationship with CQAs, create design space and model the spray drying process. Inlet temperature was identified as the only significant factor (p value <0.05) to affect dry powder particle size. Higher inlet temperatures caused drug surface melting and hence aggregation of the dried nano-crystalline ...