As we see more adults entering comprehensive orthodontic treatment, we must be more attuned to the implications of periodontal issues. In this updated chapter, Robert Vanarsdall, Ignacio Blasi and Antonino Secchi review periodontal issues... more
As we see more adults entering comprehensive orthodontic treatment, we must be more attuned to the implications of periodontal issues. In this updated chapter, Robert Vanarsdall, Ignacio Blasi and Antonino Secchi review periodontal issues that impact orthodontic tooth movement. They describe periodontal "high risk" factors, mucogingival considerations, and problems with ectopic as well as ankylosed teeth. A new section on alveolar decortication and augmentation grafting has been added to address the increased use of these procedures designed to develop the alveolar housing and potentially increase the speed of tooth movement. Excellent clinical examples are pictured throughout the chapter.
Rapid palatal expansion (RPE) has been used primarily to treat dental crossbites or for space gaining to prevent extractions with little or no attempt made to coordinate or normalize the transverse skeletal pattern. Traditionally,... more
Rapid palatal expansion (RPE) has been used primarily to treat dental crossbites or for space gaining to prevent extractions with little or no attempt made to coordinate or normalize the transverse skeletal pattern. Traditionally, maxillary orthopedics has been performed using the dental units only as anchorage (e.g., Hyrax or Haas appliances). Dental anchorage not only has created limited skeletal orthopedic change, but also can cause significant adverse periodontal outcomes and unstable side effects. There is a clear correlation between buccal tooth movement and gingival recession and bone dehiscences. These adverse periodontal responses with RPE indicate the importance of early treatment. The beneficial periodontal effects of transverse skeletal correction have been a primary focus of our research for the past 35 to 40 years. We have emphasized the importance of correcting transverse skeletal discrepancy to: 1) prevent periodontal problems; 2) achieve greater dental and skeletal stability; 3) improve dentofacial esthetics by eliminating or improving buccal corridors; and 4) improve airway resistance. When it may be critical to save the natural dentition, we do not want to introduce adverse dental/skeletal changes for adolescent patients and/or patients with advanced periodontal disease. New advances in skeletal anchorage should permit orthopedic change without adverse dental changes by applying force directly to the maxillary bone; an innovative technique to maximize the skeletal maxillary changes in the transverse dimension is explained in this chapter. Furthermore, diagnosis of the transverse dimension—the use of cone-beam computed tomography (CBCT) for 3D evaluation of skeletal changes, the benefits of the skeletal transverse changes of the whole maxillofacial complex and its periodontal response, the changes in airway and non surgical RPE with bone-anchored appliances utilizing temporary anchorage devices (TADs)—is described and discussed.
Ratings of perceived exertion (RPE: 0–10) during resistance training with varying programming demands were examined. Blood lactate (BLa) and muscle activation (using surface electromyography: EMG) were measured as potential mediators of... more
Ratings of perceived exertion (RPE: 0–10) during resistance training with varying programming demands were examined. Blood lactate (BLa) and muscle activation (using surface electromyography: EMG) were measured as potential mediators of RPE responses. Participants performed three sets of single arm (preferred side) bicep curls at 70% of 1 repetition maximum over 4 trials: Trial (A) 3 sets × 8 repetitions × 120 s recovery between sets; (B) 3 sets × 8 repetitions × 240 s recovery; (C) 3 sets × maximum number of repetitions (MNR) × 120 s recovery; (D) 3 sets ×MNR× 240 s recovery. Overall body (RPE-O) and active muscle (RPE-AM) perceptual responses were assessed following each set in each trial. Biceps brachii and brachioradialis muscle EMG was measured during each set for each trial. RPE-O and RPE-AM were not different between Trial A (3.5 ± 1 and 6 ± 1, respectively) and Trial B (3.5 ± 1 and 5.5 ± 1, respectively) (p < .05). However, RPE-AM was significantly greater in Trial C (7.5 ± 1.5) and Trial D (7.5 ± 1.5) than in Trial B (p < .05). There were no significant differences in muscle activation or BLa between trials; however, work rate (tonnage/min) was greater in Trials C and D compared to Trial B. In conclusion, BLa and muscle activation were not related to RPE, but resistance training variables, such as work rate, may impact on RPE when intensity (%1RM) and the number of sets completed remain constant.
This paper presents two arguments against the pace-based approach to running, defined as the reduction of training intensity to measures of distance/time (that is, pace). The experimental data of Daniels (5) is presented as an example of... more
This paper presents two arguments against the pace-based approach to running, defined as the reduction of training intensity to measures of distance/time (that is, pace). The experimental data of Daniels (5) is presented as an example of this. It is argued that the pace-based approach ignores many variables that are important in understanding the physiology and psychology of training long distance runners. The first argument examines the assumption that pace may be used as a general approximation of intensity. This ignores the role of confounding environmental factors like altitude, temperature, and wind. The second argument examines the assumption that any measure of intensity is as good as or better than another. Heart rate, blood-lactate levels, and volume of oxygen consumption are physiological markers that provide useful information for understanding levels of intensity, but their relationship is not certain.
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying... more
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease, however these do not exist for the dry form. Complement factor H (CFH) polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, retinal pigment epithelium (RPE) damage and visual decline. We have derived and characterised induced pluripotent stem cell (iPSCs) lines from two patients without AMD and low risk genotype and two pa‐ tients with advanced AMD and high risk genotype and generated RPE cells that show local secretion of several proteins involved in the complement pathway including factor H (FH), factor I (FI) and factor H like 1 (FHL‐1). The iPSC RPE cells derived from high risk patients mimic several key features of AMD including increased inflammation and cellular stress, accumulation of lipid droplets, impaired autophagy and deposition of " drüsen " like depos‐ its. The low and high risk RPE cells respond differently to intermittent ex‐ posure to UV light which leads to an improvement in cellular and function‐ al phenotype only in the high risk AMD‐RPE cells. Taken together our data indicate that the patient specific iPSC model provides a robust platform for understanding the role of complement activation in AMD, evaluating new therapies based on complement modulation and drug testing. STEM CELLS 2017; 00:000–000 SIGNIFICANCE STATEMENT: Age related macular degeneration (AMD) is the one of the most common forms of blindness. Drugs that treat wet AMD have been a major break‐ through; however there is currently no treatment for the dry form. One of the problems with studying AMD is that the affected retinal tissue is difficult to obtain, there are no animal models that faithfully mimic the disease and human trials are long and costly. Herein, we report creation of a disease
The paper describes the effects of pulsed laser irradiation on a solid bulk crystal. New approach is developed, which comprises the RPE-type resonant signals obtained from the conduction of the electrons of Ca metal and the hydrogen... more
The paper describes the effects of pulsed laser irradiation on a solid bulk crystal. New approach is developed, which comprises the RPE-type resonant signals obtained from the conduction of the electrons of Ca metal and the hydrogen centers, that are defects induced by irradiation in a CaF2 sample.
The paper describes the effects of pulsed laser irradiation on a solid bulk crystal. New approach is developed, which comprises the RPE-type resonant signals obtained from the conduction of the electrons of Ca metal and the hydrogen... more
The paper describes the effects of pulsed laser irradiation on a solid bulk crystal. New approach is developed, which comprises the RPE-type resonant signals obtained from the conduction of the electrons of Ca metal and the hydrogen centers, that are defects induced by irradiation in a CaF2 sample.
Ageing changes in the cardiovascular, respiratory, central nervous system and musculoskeletal systems etc results in an overall reduction of functional capacity, which may affect daily activities in middle age group individuals. So... more
Ageing changes in the cardiovascular, respiratory, central nervous system and musculoskeletal systems etc results in an overall reduction of functional capacity, which may affect daily activities in middle age group individuals. So assessment of functional capacity is an important aspect in this population group. The 6 Minute walk test is extensively being used to assess the functional capacity as it is more reflective of activities of daily living than the other walk tests and it is easy to administer and better tolerated. Treadmills can be an efficient, and space-saving alternative for performing the standard 6 MWT, as it saves the space, and enables constant hemodynamic surveillance that is necessary for the safety test performance, and will also minimize the errors in calculating the various parameters during the 6MWT. The aim of the study: This study is aimed at comparing the physiological responses and the distance walked during the 6MWT on level ground (LG) and on a Treadmill (TM) in normal healthy middle age group individuals. The results showed a statistically significant increase in blood pressures, heart rate, respiratory rate and RPE on Borg's scale (P < 0.001) and, statistically significant decrease in six-minute walk distance (P < 0.001) after the TM 6MWT as compared to the LG 6MWT. The present study was attempted to analyze the comparative effects of TM 6MWT and LG 6MWT on physiological responses and distance walked in healthy middle group individuals. There was a significant increase in physiological responses from the baseline after TM 6MWT as compared to LG 6MWT in healthy middle group individuals. There was a significant decrease in 6-minute walk distance after TM 6MWT as compared to LG 6MWT in healthy middle group individuals.
Introduction: The effect of the maxillary expander on the inferior third of the face may be conditioned by the type of expander when done with an occlusally bonded acrilic covering or on conventional bands. Objective: The purpose of this... more
Introduction: The effect of the maxillary expander on the inferior third of the face may be conditioned by the type of expander when done with an occlusally bonded acrilic covering or on conventional bands. Objective: The purpose of this retrospective study was to compare the effects of expander design on the vertical plane using a) a banded Haas expander and, b) a Haas expander with acrilic covering, in the Steiner mandibular plane. Materials and Methods: Initial (before treatment) and final (months after expander removal) lateral cephalometric x-rays of 20 patients with disjunction were retrospectively compared: ten patients with Haas expanders bonded with acrilic covering and ten patients with banded Haas expanders. The reference plane employed was S-Na. The mandibular plane was Go-Gn anatomic. Results: Significant differences existed between both groups before initiating treatment. It was observed in the group with banded Haas expanders that the mandibular plane of 5 subjects remained unchanged while increasing in the other 5 subjects. The mean initial mandibular plane was 34.7º, while the final mean was 35.55º. No significant differences existed. With respect to the group with Haas expanders with acrilic covering, the mandibular plane did not change in four subjects, while decreasing 5 others and increasing by 4º in one individual. Average initial mandibular plane was 39.25º; The final average was 38.85º. There were, similarly no significant differences present in this group. Conclusions: Rapid Palatal Expansions (RPE) conducted with banded Haas expanders remains unchanged or increase lightly the mandibular plane. On the contrary, those conducted with acrilic covered expanders tend to either maintain or decrease the mandibular plane angle. The acrilic covered expander appears to provide some control over vertical dimension, thus indicating its more appropriate use in patients with increased vertical dimension such as dolichofacial patterns. Conclusions from this study are based on results obtained from a retrospective study in which samples were not randomly chosen. We think that further prospective research studies on the effect of maxilliary expansion on facial pattern should be done.
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1–F5... more
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1–F5 in ascending order of density) by discontinuous sucrose density gradient centrifugation. The dry weight of each fraction was measured and A2E was quantified by liquid chromatography/mass spectrometry (LC/MS) using a synthetic A2E homolog as a standard. Autofluorescence emission was characterized by a customer-built spectro-fluorometer system. A significant A2E level was detected in every fraction, and the highest level was found in F1, a low-density fraction that makes up half of the total weight of all RPE granules, contains 67% of all A2E, and emits 75% of projected autofluorescence by all RPE granules. This group of RPE granules, not described previously, is therefore the most abundant RPE lipofuscin granule population. A progressive decrease in...
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1-F5... more
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1-F5 in ascending order of density) by discontinuous sucrose density gradient centrifugation. The dry weight of each fraction was measured and A2E was quantified by liquid chromatography/mass spectrometry (LC/MS) using a synthetic A2E homolog as a standard. Autofluorescence emission was characterized by a customer-built spectro-fluorometer system. A significant A2E level was detected in every fraction, and the highest level was found in F1, a low-density fraction that makes up half of the total weight of all RPE granules, contains 67% of all A2E, and emits 75% of projected autofluorescence by all RPE granules. This group of RPE granules, not described previously, is therefore the most abundant RPE lipofuscin granule population. A progressive decrease in autofluorescence was observed from F2 to F4, whereas no autofluorescence emission was detected from the heavily pigmented F5. The identification of a novel and major RPE lipofuscin population could have significant implications in our understanding of A2E and lipofuscin in human RPE.
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1–F5... more
A2E (N-retinylidene-N-retinylethanolamine) is a major fluorophore in the RPE (retinal pigment epithelium). To identify and characterize A2E-rich RPE lipofuscin, we fractionated RPE granules from human donor eyes into five fractions (F1–F5 in ascending order of density) by discontinuous sucrose density gradient centrifugation. The dry weight of each fraction was measured and A2E was quantified by liquid chromatography/mass spectrometry (LC/MS) using a synthetic A2E homolog as a standard. Autofluorescence emission was characterized by a customer-built spectro-fluorometer system. A significant A2E level was detected in every fraction, and the highest level was found in F1, a low-density fraction that makes up half of the total weight of all RPE granules, contains 67% of all A2E, and emits 75% of projected autofluorescence by all RPE granules. This group of RPE granules, not described previously, is therefore the most abundant RPE lipofuscin granule population. A progressive decrease in...