Reproductive Sciences

Figures will be available only online Underline represents presenting author; Asterisk represents senior author; Dagger represents an in-training author. 58A Reproductive Sciences Vol. 27, Supplement 1, March 2020 Scientifi c Abstracts O-001 Premenstrual Dysphoric Disorder (PMDD) is Associated with Estradiol-dependent Aberrations in Cellular Ca2+ Homeostasis and the Endoplasmic Reticulum Stress Response. Howard Li†,1,2 Neelima Dubey†,2 Jessica F Hoff man†,2 David R Rubinow,3 Peter J Schmidt∗,2 David Goldman∗.4 1Yale School of Medicine, New Haven, CT, United States; 2National Institute of Mental Health (NIMH), Bethesda, MD, United States; 3UNC Chapel Hill, Chapel Hill, NC, United States; 4National Institute of Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD, United States. Introduction: Premenstrual Dysphoric Disorder (PMDD) is characterized by debilitating mood symptoms during the luteal phase of the menstrual cycle. Evidence suggests an etiology involving an abnormal response to...

Uterine fibroids are common benign tumors that occur in up to 80% of women. Approximately half of the women affected experience considerable physical, psychological, and economic burdens and impact on quality of life due to symptoms such as heavy menstrual bleeding, pelvic pain, and infertility. Several medical and surgical options are available to treat uterine fibroids; however, healthcare providers may benefit from practical guidance in the development of individualized treatment plans based on a personalized approach. Medical treatments and minimally invasive procedures are generally preferred by most patients before considering more invasive, higher risk surgical interventions. In general, patient-centered, uterine-preserving procedures may be prioritized based on the patient’s goals and the clinical scenario. Occasionally, hysterectomy may be the preferred treatment option for some patients who require definitive treatment. This call-to-action highlights recent challenges to p...

The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle cyclic nucleotide levels which releases oocytes from the first meiotic arrest. In the ovarian follicle, the LH signal reduces cyclic nucleotide levels via the CNP/NPR2 system, the EGF/EGF receptor network, and follicle/oocyte gap junctions. In the oocyte, reduced cyclic nucleotide levels activate the maturation promoting factor (MPF). The activated MPF induces chromosome segregation and completion of the first and second meiotic divisions. The purpose of this paper is to present an overview of the current understanding of human LH signaling regulation of oocyte meiotic maturation by identifying and integrating the human studies on this topic. We found 89 human studies in the literature that identified 24 LH follicle/oocyte signaling proteins. These studies show that human oocyte meiotic maturation is regu...